Protein Alignment Ugt316A1 and UGT2B7

DIOPT Version :10

• Sequence 1: NP_649085.1
• Gene: Ugt316A1 / 40079
• FlyBaseID: FBgn0036842
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_001065.2
• Gene: UGT2B7 / 7364
• HGNCID: 12554
• Length: 529
• Species: Homo sapiens
• Alignment Length: 535
• Identity: 120/535 - (22%)
• Similarity: 235/535 - (43%)
• Gaps: 76/535 - (14%)

  Fly    13 CGIVLGANVLTVFPSVWK---SHYLFGRRLLQELVESSGNHSVTLISPHAA-------QEGVDAE 67
            ||.||          ||.   ||::..:.:|.||::.  .|.||:::..|:       ...:..|
Human    23 CGKVL----------VWAAEYSHWMNIKTILDELIQR--GHEVTVLASSASILFDPNNSSALKIE 75

  Fly    68 I--PKIRELRIEGL----RENWLDMGM-SFEAEEMRAQSVMERFTRLIYAGTTN---VDILLSDP 122
            |  ..:.:..:|..    .:.|.|:.. :|.....:.|.:|.     |:...|.   .|::.:..
Human    76 IYPTSLTKTELENFIMQQIKRWSDLPKDTFWLYFSQVQEIMS-----IFGDITRKFCKDVVSNKK 135

  Fly   123 QVRKLLTSGEKFDLLIVDLFLSDALLGLAFYYGIP---TVAVSPTGANSWLNNMFGNPQSSSLDP 184
            .::|:..|  :||::..|.....:.| ||..:.||   :::.||       ...|.......:.|
Human   136 FMKKVQES--RFDVIFADAIFPCSEL-LAELFNIPFVYSLSFSP-------GYTFEKHSGGFIFP 190

  Fly   185 SNFLP-----FTERMNTRQRILNSLMSTFERLTYNFFHLISQQSVYTNHFELLVKELPLYRDLTK 244
            .:::|     .|::|...:|:.|.:...:....:..|.:......|:   |:|.:...|...:.|
Human   191 PSYVPVVMSELTDQMTFMERVKNMIYVLYFDFWFEIFDMKKWDQFYS---EVLGRPTTLSETMGK 252

  Fly   245 NLSLALINSHPGLHYPRAYLPNMVEVGGLHLSHLNDDNLPKHLLSFMESA-PSGVIYFSLGADVE 308
             ..:.||.:.....:|...|||:..|||||......  |||.:..|::|: .:||:.||||:.|
Human   253 -ADVWLIRNSWNFQFPYPLLPNVDFVGGLHCKPAKP--LPKEMEDFVQSSGENGVVVFSLGSMV- 313

  Fly   309 TAQLPQEKLAIILDVFGHLKEFHFLLKWEKEEFTAEQVLPENVMIADWWPQQAILHHPQVKMFIS 373
             :.:.:|:..:|......:.:   .:.| :.:......|..|..:..|.||..:|.||:.:.||:
Human   314 -SNMTEERANVIASALAQIPQ---KVLW-RFDGNKPDTLGLNTRLYKWIPQNDLLGHPKTRAFIT 373

  Fly   374 SCGQLSVWESISGQKPVLAIPILAEQEVMAKRLQRHGVSVTVGYDSLAYDSLLHGIRQLTLNTSY 438
            ..|...::|:|....|::.||:.|:|......::..|.:|.|.:::::...||:.::::..:.||
Human   374 HGGANGIYEAIYHGIPMVGIPLFADQPDNIAHMKARGAAVRVDFNTMSSTDLLNALKRVINDPSY 438

  Fly   439 VEKLGQLKERLISRDSTPVGKAVRKIQLILESGGADFLKSHANTLNFWRAEGVDVLLIIAVGFFG 503
            .|.:.:|......:...|:.:||..|:.::...||..|:..|:.|.:::...:||:        |
Human   439 KENVMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVI--------G 495

  Fly   504 ILTIPFLAICFILRK 518
            .|.:....:.||:.|
Human   496 FLLVCVATVIFIVTK 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt316A1	NP_649085.1	GT1_Gtf-like	19..461	CDD:340817	101/470 (21%)
UGT2B7	NP_001065.2	UDPGT	24..525	CDD:278624	119/534 (22%)