Protein Alignment Ugt316A1 and UGT1A9

DIOPT Version :10

• Sequence 1: NP_649085.1
• Gene: Ugt316A1 / 40079
• FlyBaseID: FBgn0036842
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_066307.1
• Gene: UGT1A9 / 54600
• HGNCID: 12541
• Length: 530
• Species: Homo sapiens
• Alignment Length: 523
• Identity: 126/523 - (24%)
• Similarity: 239/523 - (45%)
• Gaps: 61/523 - (11%)

  Fly    11 LLCGIVLGANVLTVFPSVWKSHYLFGRRLLQELVESSGNHSVTLISPHAAQEGVDAEIPKIRELR 75
            |.||......:|.|  .:..||:...|.::::|:  ...|.|.::.|.     |..::.:.....
Human    18 LTCGFAEAGKLLVV--PMDGSHWFTMRSVVEKLI--LRGHEVVVVMPE-----VSWQLGRSLNCT 73

  Fly    76 IEGLRENWL--DMGMSFEA---EEMRAQSVMERFTRLIYA---GTTNVDI----------LLSDP 122
            ::....::.  |:...|:|   .:.:||      .|.||:   |:.| ||          |..|.
Human    74 VKTYSTSYTLEDLDREFKAFAHAQWKAQ------VRSIYSLLMGSYN-DIFDLFFSNCRSLFKDK 131

  Fly   123 QVRKLLTSGEKFDLLIVDLFLSDALLGLAFYYGIPTVAVSPTGANSWLNNMFGNPQSSSLDPSNF 187
            ::.:.|.. ..||.:.:|.|.:..|: :|.|:.:|:|..:......:|......|...|..|...
Human   132 KLVEYLKE-SSFDAVFLDPFDNCGLI-VAKYFSLPSVVFARGILCHYLEEGAQCPAPLSYVPRIL 194

  Fly   188 LPFTERMNTRQRILNSLMSTFERLTYNFFHLISQQSVYTNHFELL--VKELPLYR-DLTKNLSLA 249
            |.|::.|..::|:.|.:|...|.|..:.|        :.|..|:.  :.:.|:.. ||..:.|:.
Human   195 LGFSDAMTFKERVRNHIMHLEEHLLCHRF--------FKNALEIASEILQTPVTEYDLYSHTSIW 251

  Fly   250 LINSHPGLHYPRAYLPNMVEVGGLHLSHLNDDNLPKHLLSFME-SAPSGVIYFSLGADVETAQLP 313
            |:.:...|.||:..:|||:.:||::..  ....||....:::. |...|::.||||:.|  :::|
Human   252 LLRTDFVLDYPKPVMPNMIFIGGINCH--QGKPLPMEFEAYINASGEHGIVVFSLGSMV--SEIP 312

  Fly   314 QEKLAIILDVFGHLKEFHFLLKWEKEEFTAEQVLPENVMIADWWPQQAILHHPQVKMFISSCGQL 378
            ::|...|.|..|.:.:   .:.| :...|....|..|.::..|.||..:|.||..:.||:..|..
Human   313 EKKAMAIADALGKIPQ---TVLW-RYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSH 373

  Fly   379 SVWESISGQKPVLAIPILAEQEVMAKRLQRHGVSVTVGYDSLAYDSLLHGIRQLTLNTSYVEKLG 443
            .|:|||....|::.:|:..:|...|||::..|..||:....:..:.|.:.::.:..:.||.|.:.
Human   374 GVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIM 438

  Fly   444 QLKERLISRDSTPVGKAVRKIQLILESGGADFLKSHANTLNFWRAEGVDVL-LIIAVGFFGILTI 507
            :|......|...|:..||..::.::...||..|:..|:.|.:::...:||: .::||    :||:
Human   439 RLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAV----VLTV 499

  Fly   508 PFL 510
            .|:
Human   500 AFI 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt316A1	NP_649085.1	GT1_Gtf-like	19..461	CDD:340817	109/463 (24%)
UGT1A9	NP_066307.1	UDPGT	26..521	CDD:278624	123/515 (24%)