Protein Alignment Ugt316A1 and UGT1A6

DIOPT Version :10

• Sequence 1: NP_649085.1
• Gene: Ugt316A1 / 40079
• FlyBaseID: FBgn0036842
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_001063.2
• Gene: UGT1A6 / 54578
• HGNCID: 12538
• Length: 532
• Species: Homo sapiens
• Alignment Length: 523
• Identity: 137/523 - (26%)
• Similarity: 240/523 - (45%)
• Gaps: 62/523 - (11%)

  Fly    12 LCGIVLGANVLTVFPSVWKSHYLFGRRLLQELVE--SSGNHSVTLISPHAAQEGVDAEIPKIREL 74
            |.|:|:|..:|.|...  .||:|    .::::||  |...|.:.::.|   :..:..:..|....
Human    20 LWGMVVGDKLLVVPQD--GSHWL----SMKDIVEVLSDRGHEIVVVVP---EVNLLLKESKYYTR 75

  Fly    75 RI-------EGLRENWLDMGMSFEAEEMRAQSVMERF-TRLIYAGT--TNVDILLSDPQVRKLLT 129
            :|       |.|:..:...|.:..||.....:....: ..:|..|.  .|...||.|........
Human    76 KIYPVPYDQEELKNRYQSFGNNHFAERSFLTAPQTEYRNNMIVIGLYFINCQSLLQDRDTLNFFK 140

  Fly   130 SGEKFDLLIVDLFLSDALLGLAFYYGIPTVAVSPTGANSWLNNMFGNPQSSSLDPSNFLP----- 189
            . .|||.|..|..|...:: ||.|.|:|:|.:. .|....|.:.|    |.|.||.:::|
Human   141 E-SKFDALFTDPALPCGVI-LAEYLGLPSVYLF-RGFPCSLEHTF----SRSPDPVSYIPRCYTK 198

  Fly   190 FTERMNTRQRILNSLMSTFERLTYNFFHLISQQSVYTNHFELLVKELPLYRD-----LTKNLSLA 249
            |::.|...||:.|.|::..|  .|.|:.|.|:       :|.|...: |.||     |.:.:|:.
Human   199 FSDHMTFSQRVANFLVNLLE--PYLFYCLFSK-------YEELASAV-LKRDVDIITLYQKVSVW 253

  Fly   250 LINSHPGLHYPRAYLPNMVEVGGLHLSHLNDDNLPKHLLSFME-SAPSGVIYFSLGADVETAQLP 313
            |:.....|.|||..:||||.:||::.....|  |.:...:::. |...|::.||||:.|  :::|
Human   254 LLRYDFVLEYPRPVMPNMVFIGGINCKKRKD--LSQEFEAYINASGEHGIVVFSLGSMV--SEIP 314

  Fly   314 QEKLAIILDVFGHLKEFHFLLKWEKEEFTAEQVLPENVMIADWWPQQAILHHPQVKMFISSCGQL 378
            ::|...|.|..|.:.:   .:.| :...|....|..|.::..|.||..:|.||..:.||:..|..
Human   315 EKKAMAIADALGKIPQ---TVLW-RYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSH 375

  Fly   379 SVWESISGQKPVLAIPILAEQEVMAKRLQRHGVSVTVGYDSLAYDSLLHGIRQLTLNTSYVEKLG 443
            .|:|||....|::.:|:..:|...|||::..|..||:....:..:.|.:.::.:..:.||.|.:.
Human   376 GVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIM 440

  Fly   444 QLKERLISRDSTPVGKAVRKIQLILESGGADFLKSHANTLNFWRAEGVDVL-LIIAVGFFGILTI 507
            :|......|...|:..||..::.::...||..|:..|:.|.:::...:||: .::||    :||:
Human   441 RLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAV----VLTV 501

  Fly   508 PFL 510
            .|:
Human   502 AFI 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt316A1	NP_649085.1	GT1_Gtf-like	19..461	CDD:340817	119/464 (26%)
UGT1A6	NP_001063.2	UDPGT	27..523	CDD:278624	133/516 (26%)