Protein Alignment Ugt316A1 and UGT1A8

DIOPT Version :10

• Sequence 1: NP_649085.1
• Gene: Ugt316A1 / 40079
• FlyBaseID: FBgn0036842
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_061949.3
• Gene: UGT1A8 / 54576
• HGNCID: 12540
• Length: 530
• Species: Homo sapiens
• Alignment Length: 517
• Identity: 124/517 - (23%)
• Similarity: 236/517 - (45%)
• Gaps: 49/517 - (9%)

  Fly    11 LLCGIVLGANVLTVFPSVWKSHYLFGRRLLQELVESSGNHSVTLISPHAAQE---GVDAEIPKI- 71
            |.||......:|.|  .:..||:...:.::::|:  ...|.|.::.|..:.:   .::..:...
Human    18 LTCGFAEAGKLLVV--PMDGSHWFTMQSVVEKLI--LRGHEVVVVMPEVSWQLGKSLNCTVKTYS 78

  Fly    72 RELRIEGLRENWLDMGMSFEAEEMRAQ---------SVMERFTRLIYAGTTNVDILLSDPQVRKL 127
            ....:|.|...::|    |...:.:||         |....|..|.::...:   |.:|   |||
Human    79 TSYTLEDLDREFMD----FADAQWKAQVRSLFSLFLSSSNGFFNLFFSHCRS---LFND---RKL 133

  Fly   128 L--TSGEKFDLLIVDLFLSDALLGLAFYYGIPTVAVSPTGANSWLNNMFGNPQSSSLDPSNFLPF 190
            :  .....||.:.:|.|.:..|: :|.|:.:|:|..:...|..:|......|...|..|...|.|
Human   134 VEYLKESSFDAVFLDPFDACGLI-VAKYFSLPSVVFARGIACHYLEEGAQCPAPLSYVPRILLGF 197

  Fly   191 TERMNTRQRILNSLMSTFERLTYNFFHLISQQSVYTNHFELLVKELPLYRDLTKNLSLALINSHP 255
            ::.|..::|:.|.:|...|.|...:|    .::......|:|...:..| ||..:.|:.|:.:..
Human   198 SDAMTFKERVRNHIMHLEEHLFCQYF----SKNALEIASEILQTPVTAY-DLYSHTSIWLLRTDF 257

  Fly   256 GLHYPRAYLPNMVEVGGLHLSHLNDDNLPKHLLSFME-SAPSGVIYFSLGADVETAQLPQEKLAI 319
            .|.||:..:|||:.:||::..  ....||....:::. |...|::.||||:.|  :::|::|...
Human   258 VLDYPKPVMPNMIFIGGINCH--QGKPLPMEFEAYINASGEHGIVVFSLGSMV--SEIPEKKAMA 318

  Fly   320 ILDVFGHLKEFHFLLKWEKEEFTAEQVLPENVMIADWWPQQAILHHPQVKMFISSCGQLSVWESI 384
            |.|..|.:.:   .:.| :...|....|..|.::..|.||..:|.||..:.||:..|...|:|||
Human   319 IADALGKIPQ---TVLW-RYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESI 379

  Fly   385 SGQKPVLAIPILAEQEVMAKRLQRHGVSVTVGYDSLAYDSLLHGIRQLTLNTSYVEKLGQLKERL 449
            ....|::.:|:..:|...|||::..|..||:....:..:.|.:.::.:..:.||.|.:.:|....
Human   380 CNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLH 444

  Fly   450 ISRDSTPVGKAVRKIQLILESGGADFLKSHANTLNFWRAEGVDVL-LIIAVGFFGILTIPFL 510
            ..|...|:..||..::.::...||..|:..|:.|.:::...:||: .::||    :||:.|:
Human   445 KDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAV----VLTVAFI 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt316A1	NP_649085.1	GT1_Gtf-like	19..461	CDD:340817	107/457 (23%)
UGT1A8	NP_061949.3	UDPGT	26..521	CDD:278624	121/509 (24%)