Protein Alignment Ugt316A1 and UGT2B28

DIOPT Version :10

• Sequence 1: NP_649085.1
• Gene: Ugt316A1 / 40079
• FlyBaseID: FBgn0036842
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_444267.1
• Gene: UGT2B28 / 54490
• HGNCID: 13479
• Length: 529
• Species: Homo sapiens
• Alignment Length: 552
• Identity: 122/552 - (22%)
• Similarity: 238/552 - (43%)
• Gaps: 84/552 - (15%)

  Fly     3 ILQVFLGTLL----CGIVLGANVLTVFPSVWK---SHYLFGRRLLQELVESSGNHSVTLISPHAA 60
            :|.:.||...    ||.||          ||.   ||::..:.:|:|||:.  .|.||:::..|:
Human     9 LLLIHLGCYFSSGSCGKVL----------VWTGEYSHWMNMKTILKELVQR--GHEVTVLASSAS 61

  Fly    61 --QEGVDAEIPKIR-------ELRIEGL----RENWLDMGM-SFEAEEMRAQSVMERFTRLIYAG 111
              .:..||...|:.       :...|.:    .:.|.|:.. ||.....:.|.::..|..:....
Human    62 ILFDPNDAFTLKLEVYPTSLTKTEFENIIMQQVKRWSDIQKDSFWLYFSQEQEILWEFHDIFRNF 126

  Fly   112 TTNVDILLSDPQVRKLLTSGEKFDLLIVDLF-----LSDALLGLAFYYGI---PTVAVSPTGANS 168
            ..:|   :|:.:|.|.|.. .:||::..|.|     |..|||.:.|.|.:   |...:.
Human   127 CKDV---VSNKKVMKKLQE-SRFDIIFADAFFPCGELLAALLNIPFVYSLCFTPGYTIE------ 181

  Fly   169 WLNNMFGNPQSSSLDPSNFLP-----FTERMNTRQRILNSLMSTFERLTYNFFHLISQQSVYTNH 228
                   ......:.|.:::|     .:::|...:|:.|.:..    |.::|:..:.....:...
Human   182 -------RHSGGLIFPPSYIPVVMSKLSDQMTFMERVKNMIYV----LYFDFWFQMCDMKKWDQF 235

  Fly   229 F-ELLVKELPLYRDLTKNLSLALINSHPGLHYPRAYLPNMVEVGGLHLSHLNDDNLPKHLLSFME 292
            : |:|.:...|:..:.| ..:.|:.:.....:|..:|||:..|||||......  |||.:..|::
Human   236 YSEVLGRPTTLFETMGK-ADIWLMRNSWSFQFPHPFLPNIDFVGGLHCKPAKP--LPKEMEEFVQ 297

  Fly   293 SA-PSGVIYFSLGADVETAQLPQEKLAIILDVFGHLKEFHFLLKWEKEEFTAEQVLPENVMIADW 356
            |: .:||:.||||:.:  :.:..|:..:|......:.:   .:.| :.:......|..|..:..|
Human   298 SSGENGVVVFSLGSVI--SNMTAERANVIATALAKIPQ---KVLW-RFDGNKPDALGLNTRLYKW 356

  Fly   357 WPQQAILHHPQVKMFISSCGQLSVWESISGQKPVLAIPILAEQEVMAKRLQRHGVSVTVGYDSLA 421
            .||..:|..|:.:.||:..|...::|:|....|::.||:..:|......::..|.:|.:.:.:::
Human   357 IPQNDLLGLPKTRAFITHGGANGIYEAIYHGIPMVGIPLFWDQPDNIAHMKAKGAAVRLDFHTMS 421

  Fly   422 YDSLLHGIRQLTLNTSYVEKLGQLKERLISRDS--TPVGKAVRKIQLILESGGADFLKSHANTLN 484
            ...||:.::.:..:.||.|.:  :|..:|..|.  .|:.:||..|:.::...||..|:..|..|.
Human   422 STDLLNALKTVINDPSYKENV--MKLSIIQHDQPVKPLHRAVFWIEFVMCHKGAKHLRVAARDLT 484

  Fly   485 FWRAEGVDVL--LIIAVGFFGILTIPFLAICF 514
            :::...:||:  |:..|.....:...|...||
Human   485 WFQYHSLDVIGFLLACVATVIFVVTKFCLFCF 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt316A1	NP_649085.1	GT1_Gtf-like	19..461	CDD:340817	100/475 (21%)
UGT2B28	NP_444267.1	UDPGT	24..525	CDD:278624	118/537 (22%)