Protein Alignment Ugt316A1 and UGT3A2

DIOPT Version :10

• Sequence 1: NP_649085.1
• Gene: Ugt316A1 / 40079
• FlyBaseID: FBgn0036842
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: XP_011512290.1
• Gene: UGT3A2 / 167127
• HGNCID: 27266
• Length: 550
• Species: Homo sapiens
• Alignment Length: 568
• Identity: 144/568 - (25%)
• Similarity: 239/568 - (42%)
• Gaps: 97/568 - (17%)

  Fly     2 QILQVFLGTLLCGIVL--GANVLTVFPSVWKSHYLFGRRLLQELVESSGNHSVTLI--------- 55
            |.:.:.:|.||.|::|  .|.:||: .:|..||||...|:.| :::..| |:||::
Human     4 QRVLLLVGFLLPGVLLSEAAKILTI-STVGGSHYLLMDRVSQ-ILQDHG-HNVTMLNHKRGPFMP 65

  Fly    56 ----SPHAAQEGVDAEIPKIRELRIEGLRENWLDMGM-SFEAEEMRAQSV--------------- 100
                ||.:|     :..|:|..|      :.:...|: .|:.||...|.:
Human    66 GLSDSPASA-----SRYPRILYL------QKYCQFGLKDFKKEEKSYQVISWLAPEDHQREFKKS 119

  Fly   101 MERFTRLIYAGTTNVDILLSDPQVRKLLTS-------------GEKFDLLIVDLFLSDALLGLAF 152
            .:.|......|....:.||:..:...|..|             .|.||::||:.|.....| :|.
Human   120 FDFFLEETLGGRGKFENLLNVLEYLALQCSHFLNRKDIMDSLKNENFDMVIVETFDYCPFL-IAE 183

  Fly   153 YYGIPTVAVSPTGANSWLNNMFGNPQSSSLDPSNFLP-----FTERMNTRQRILNSLMSTFERLT 212
            ..|.|.||:        |:..||:.:.....|.:::|     .|:.|:...|:.|.||
Human   184 KLGKPFVAI--------LSTSFGSLEFGLPIPLSYVPVFRSLLTDHMDFWGRVKNFLM------- 233

  Fly   213 YNFFHLISQQSVYTNHFELLVKE------LPLYRDLTKNLSLALINSHPGLHYPRAYLPNMVEVG 271
              ||....:|....:.|:..:||      .|:...|.....|..|||.....:.|..|||.|.||
Human   234 --FFSFCRRQQHMQSTFDNTIKEHFTEGSRPVLSHLLLKAELWFINSDFAFDFARPLLPNTVYVG 296

  Fly   272 GLHLSHLNDDNLPKHLLSFM-ESAPSGVIYFSLGADVETAQLPQEKLAIILDVFGHLKEFHFLLK 335
            ||....:..  :|:.|.:|: :...||.:..:||:.|.|.|.| |....:.:.|.||.: ..:.|
Human   297 GLMEKPIKP--VPQDLENFIAKFGDSGFVLVTLGSMVNTCQNP-EIFKEMNNAFAHLPQ-GVIWK 357

  Fly   336 WEKEEFTAEQVLPENVMIADWWPQQAILHHPQVKMFISSCGQLSVWESISGQKPVLAIPILAEQE 400
            .:...:..:..|..||.|.||.||..:|.||.:::|::..||.|:.|:|....|::.||:..:|.
Human   358 CQCSHWPKDVHLAANVKIVDWLPQSDLLAHPSIRLFVTHGGQNSIMEAIQHGVPMVGIPLFGDQP 422

  Fly   401 VMAKRLQRHGVSVTVGYDSLAYDSLLHGIRQLTLNTSYVEKLGQLKERLISRDSTPVGKAVRKIQ 465
            ....|::.....|::....|..::|...::|:..:..|..........|.|...:|..:.|..|.
Human   423 ENMVRVEAKKFGVSIQLKKLKAETLALKMKQIMEDKRYKSAAVAASVILRSHPLSPTQRLVGWID 487

  Fly   466 LILESGGADFLKSHANTLNFWRAEGVDVLLIIAVGFFGILTIPFLAIC 513
            .:|::|||..||.:.    |.:......||.:.|...| ||:..|.:|
Human   488 HVLQTGGATHLKPYV----FQQPWHEQYLLDVFVFLLG-LTLGTLWLC 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt316A1	NP_649085.1	GT1_Gtf-like	19..461	CDD:340817	121/495 (24%)
UGT3A2	XP_011512290.1	Glycosyltransferase_GTB-type	23..518	CDD:471961	132/534 (25%)