Protein Alignment Ugt316A1 and UGT2A1

DIOPT Version :10

• Sequence 1: NP_649085.1
• Gene: Ugt316A1 / 40079
• FlyBaseID: FBgn0036842
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_001376494.1
• Gene: UGT2A1 / 10941
• HGNCID: 12542
• Length: 737
• Species: Homo sapiens
• Alignment Length: 531
• Identity: 133/531 - (25%)
• Similarity: 239/531 - (45%)
• Gaps: 85/531 - (16%)

  Fly    24 VFPSVWK------------SHYLFGRRLLQELVESSGNHSVTLISPHAA-------QEGVDAEIP 69
            :|.::||            ||:|..:.:|:||::.  ||:||:::..|.       ...|:.|:.
Human   222 MFETLWKSWDSYYSKALDGSHWLNIKIILEELIQR--NHNVTVLASSATLFINSNPDSPVNFEVI 284

  Fly    70 KI--RELRIEGLREN----WLD---MGMSFEAEEMRAQSVMERFTRLIYAGTTNV---DILLSDP 122
            .:  ::..|:.|.|:    |:|   ..::..|.......:::.|.::      |:   |.:|.:|
Human   285 PVSYKKSNIDSLIEHMIMLWIDHRPTPLTIWAFYKELGKLLDTFFQI------NIQLCDGVLKNP 343

  Fly   123 QVRKLLTSGEKFDLLIVD--LFLSDAL---LGLAFYYGIPTVAVSPTGANSWLNNMFGN-PQSSS 181
            ::...|..| .||:|:.|  ....|.:   ||:.|.|   |:..||.   |.:....|. |...|
Human   344 KLMARLQKG-GFDVLVADPVTICGDLVALKLGIPFMY---TLRFSPA---STVERHCGKIPAPVS 401

  Fly   182 LDPSNFLPFTERMNTRQRILNSLMSTFERLTYNFFHLISQQSVYTNHFELLVKELPLYRDLTKNL 246
            ..|:.....|::|...:||.|::  ::....|.|.....:.:.|  :.::|.:...|...:.| .
Human   402 YVPAALSELTDQMTFGERIKNTI--SYSLQDYIFQSYWGEWNSY--YSKILGRPTTLCETMGK-A 461

  Fly   247 SLALINSHPGLHYPRAYLPNMVEVGGLHLSHLNDDNLPKHLLSFMESA-PSGVIYFSLGADVETA 310
            .:.||.::....:||.||||...|||||......  |||.:..|::|: .:||:.||||:.|:
Human   462 EIWLIRTYWDFEFPRPYLPNFEFVGGLHCKPAKP--LPKEMEEFIQSSGKNGVVVFSLGSMVK-- 522

  Fly   311 QLPQEKLAIILDVFGHLKEFHFLLKWE---KEEFTAEQVLPENVMIADWWPQQAILHHPQVKMFI 372
            .|.:||..:|......:.:   .:.|.   |:..|    |..|..:.||.||..:|.||:.|.||
Human   523 NLTEEKANLIASALAQIPQ---KVLWRYKGKKPAT----LGNNTQLFDWIPQNDLLGHPKTKAFI 580

  Fly   373 SSCGQLSVWESISGQKPVLAIPILAEQEVMAKRLQRHGVSVTVGYDSLAYDSLLHGIRQLTLNTS 437
            :..|...::|:|....|::.:|:.|:|......::..|.:|.|..:::....||..:|.:....|
Human   581 THGGTNGIYEAIYHGVPMVGVPMFADQPDNIAHMKAKGAAVEVNLNTMTSVDLLSALRTVINEPS 645

  Fly   438 YVEKLGQLKERLISRDSTPVGKAVRKIQLILESGGADFLKSHANTLNFWRAEGVDVLLIIAVGFF 502
            |.|...:|......:...|:.:||..|:.::...||..|:..|:.|.:::...:||
Human   646 YKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDV--------- 701

  Fly   503 GILTIPFLAIC 513
                |.||.:|
Human   702 ----IGFLLVC 708

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt316A1	NP_649085.1	GT1_Gtf-like	19..461	CDD:340817	119/477 (25%)
UGT2A1	NP_001376494.1	UDPGT	237..725	CDD:278624	130/516 (25%)