Protein Alignment Acp76A and SERPINA1

DIOPT Version :10

• Sequence 1: NP_524153.1
• Gene: Acp76A / 40078
• FlyBaseID: FBgn0015586
• Length: 388
• Species: Drosophila melanogaster
• Sequence 2: NP_000286.3
• Gene: SERPINA1 / 5265
• HGNCID: 8941
• Length: 418
• Species: Homo sapiens
• Alignment Length: 386
• Identity: 72/386 - (18%)
• Similarity: 142/386 - (36%)
• Gaps: 84/386 - (21%)

  Fly    19 NTIQQNV---SFQLIREI-DRYTPENFVLSVLNIEMILFEIHAAKAVESNNDLERSLIINFGYSE 79
            |.|..|:   :|.|.|:: .:....|...|.::|......:......::::::...|  ||..:|
Human    48 NKITPNLAEFAFSLYRQLAHQSNSTNIFFSPVSIATAFAMLSLGTKADTHDEILEGL--NFNLTE 110

  Fly    80 ARQEVLDWG----LRYKKASSAKFQMANKVAVSQKLPLSQKLRLVNEVLMTSAKKYDV------- 133
            ..:..:..|    ||......::.|:    .....|.||:.|:||::.|....|.|..
Human   111 IPEAQIHEGFQELLRTLNQPDSQLQL----TTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNF 171

  Fly   134 --TKDVRPSKLMDEWLSSHLDGVLANFVQE---KKLNAGENIVAISGMTVTPLWASHFQ---SEI 190
              |::.:  |.:::::.....|.:.:.|:|   ..:.|..|.:...|.     |...|:   :|.
Human   172 GDTEEAK--KQINDYVEKGTQGKIVDLVKELDRDTVFALVNYIFFKGK-----WERPFEVKDTEE 229

  Fly   191 NRYFVNNPGTGYASKDPTCVPMMHSLSSFETMSTDE-AKGIYIPFSSANLGMLILLPRKGVTCKD 254
            ..:.|:...|       ..||||..|..|......: :..:.:.....|...:..||.:|.
Human   230 EDFHVDQVTT-------VKVPMMKRLGMFNIQHCKKLSSWVLLMKYLGNATAIFFLPDEGK---- 283

  Fly   255 ILDNLNNQIN-------VEYNDHKDVHLLLPIFKEKFDYNIAKFFNGINIEDTFKDSAFKS---- 308
             |.:|.|::.       :|..|.:...|.||.......|::......:.|...|.:.|..|
Human   284 -LQHLENELTHDIITKFLENEDRRSASLHLPKLSITGTYDLKSVLGQLGITKVFSNGADLSGVTE 347

  Fly   309 KAKIKINNFRVNH--------------GIRFQPILRLEVVDDIDTGKTETFEVNRPFVFVI 355
            :|.:|::  :..|              |..|...:.:.:..::        :.|:||||::
Human   348 EAPLKLS--KAVHKAVLTIDEKGTEAAGAMFLEAIPMSIPPEV--------KFNKPFVFLM 398

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Acp76A	NP_524153.1	serpin	28..369	CDD:476815	68/374 (18%)
SERPINA1	NP_000286.3	serpinA1_A1AT	50..417	CDD:381012	71/384 (18%)
		RCL	368..392		2/31 (6%)