DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SmydA-2 and ZMYND12

DIOPT Version :9

Sequence 1:	NP_649084.1	Gene:	SmydA-2 / 40075	FlyBaseID:	FBgn0036839	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_115633.3	Gene:	ZMYND12 / 84217	HGNCID:	21192	Length:	365	Species:	Homo sapiens

Alignment Length:	378	Identity:	80/378 - (21%)
Similarity:	125/378 - (33%)	Gaps:	119/378 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 CALCQAKASQLCAACRNVVYCSREHQKEHWKKGHRSECQ-------------------------- 47
            |.:|:|.|.::||||....||...|||..|...|...||
Human    17 CEVCEAPAERVCAACTVTYYCGVVHQKADWDSIHEKICQLLIPLRTSMPFYNSEEERQHGLQQLQ 81

  Fly    48 ---------CFEIATNEVL-GRH-------LRATR-----------DIKIGEQILKEAPLVLGPK 84
                     |:.||...:. |:|       |::.|           ::.....:|.||.|.|| :
Human    82 QRQKYLIEFCYTIAQKYLFEGKHEDAVPAALQSLRFRVKLYGLSSVELVPAYLLLAEASLGLG-R 145

  Fly    85 VASAPLCLGCHRNLLAPGKPRGNYHKCSSCSWP-LCGKECEDSVHHKAECQLMSGSNFQSKINYV 148
            :..|...|                   ....|. |...:|.::.|......|  |..:.:|.||
Human   146 IVQAEEYL-------------------FQAQWTVLKSTDCSNATHSLLHRNL--GLLYIAKKNY- 188

  Fly   149 PGEEERKESAYCVIMLLRCMHLKD-KDPDAFLKLYNLEDHLK-----ERLETPLYQVLRANLITF 207
              ||.|...|..:.........:| :....:..|.|:...||     :.|.|.:.::..|.|...
Human   189 --EEARYHLANDIYFASCAFGTEDIRTSGGYFHLANIFYDLKKLDLADTLYTKVSEIWHAYLNNH 251

  Fly   208 IKTVLGMKDWPEMDILRIAAILDTNTFEVRQPRERRKIRALYPGAAMISHDCVPNMRHRFDD--D 270
            .: ||......:||:|   ..|..|...:.:.:|...||.|         ..:.|:|....|  .
Human   252 YQ-VLSQAHIQQMDLL---GKLFENDTGLDEAQEAEAIRIL---------TSILNIRESTSDKAP 303

  Fly   271 MNIVFLAKRKI---------AKGE-----ILSISYTQPL----RSTIQRRVHL 305
            ...:|:.|..:         :|.:     .||::..|.|    :||||..:.|
Human   304 QKTIFVLKILVMFYYLMMNSSKAQEYGMRALSLAKEQQLDVHEQSTIQELLSL 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SmydA-2	NP_649084.1	zf-MYND	9..46	CDD:280009	15/36 (42%)
SmydA-2	NP_649084.1	SET	<246..291	CDD:214614	10/60 (17%)
ZMYND12	NP_115633.3	zf-MYND	17..54	CDD:280009	15/36 (42%)
		TPR repeat	88..116	CDD:276809	6/27 (22%)
		TPR_12	92..156	CDD:290160	14/83 (17%)
		TPR repeat	129..167	CDD:276809	10/57 (18%)
		TPR 1	172..205		9/37 (24%)
		TPR repeat	172..195	CDD:276809	8/27 (30%)
		TPR_12	174..243	CDD:290160	16/73 (22%)
		TPR 2	214..247		6/32 (19%)
		TPR repeat	214..242	CDD:276809	6/27 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910