DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SmydA-2 and smyd1b

DIOPT Version :9

Sequence 1:	NP_649084.1	Gene:	SmydA-2 / 40075	FlyBaseID:	FBgn0036839	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001034725.1	Gene:	smyd1b / 569027	ZFINID:	ZDB-GENE-060522-1	Length:	486	Species:	Danio rerio

Alignment Length:	547	Identity:	114/547 - (20%)
Similarity:	204/547 - (37%)	Gaps:	152/547 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 GRHLRATRDIKIGEQILKEAPL--VLGPKVASAPLCLGCHRNLLAPGKPRGNYHKCSSCSW-PLC 119
            ||.||||::...|:.:..|.|.  |:....||: :|..|.|.       :....:|..|.: ..|
Zfish    13 GRGLRATKEAWAGDVLFAEPPFASVVFDSQASS-ICHSCFRR-------QEKLQRCGQCRFAQYC 69

  Fly   120 GKECEDS--VHHKAECQLMSGSNFQSKINYVPGEEERKESAYCVIMLLRCMHLKDK-----DPDA 177
            .|.|:.:  ..||.||..:      ......|.|..|        :..|.:...||     ..:.
Zfish    70 DKTCQRAGWEEHKLECAAI------KTYGKPPSENVR--------LAARILWRMDKQGSVVSDNQ 120

  Fly   178 FLKLYNLEDHLKERLETPL--YQVLRANLITFIKTVLGMKDWPEM-------DILRIAAILDTNT 233
            ...|.:||||:.:..|..|  ::|...|.:.:         ||..       .:..|..:::.|.
Zfish   121 LTTLEDLEDHICDISEDDLKDFKVDIHNFLDY---------WPRNSKPHTVDSVSHILGVINCNG 176

  Fly   234 FEVRQPRERRKIR-ALYPGAAMISHDCVPN----MRHRFDDDMNIVFLAKR--------KIAKGE 285
            |.|...|..:.:. .|:|...:::|||.||    :.:.....::.||.:::        ||:.||
Zfish   177 FMVSDQRGLQAVGVGLFPNLCLVNHDCWPNCTVILNNGNQSAIDTVFHSQKRIELRALGKISAGE 241

  Fly   286 ILSISYTQPLRSTIQRRVHLRQAKCFDCSCARCQD--PEELGSFAGAQTCLKCKAGKIISLNPLL 348
            .::::|...|..:..|:..|:|...|||:|..|.:  .::| ..|||:.    ...|:
Zfish   242 EVTVAYVDYLNVSADRQRLLKQQYFFDCTCKHCTEKIKDDL-KMAGAEV----DGVKV------- 294

  Fly   349 NSAPWKCQLCNFKRSAKDVVTSDAELQQELESLDKTTPVA--------LEEFIYRHRADLHETNT 405
               |        :...|:|....   :|:||.::|....|        ..|.:.:....|.:|:.
Zfish   295 ---P--------EEQVKEVTEFS---RQKLEKMEKARIEANYNEVVKICRECVEKQENVLADTHI 345

  Fly   406 HILQAKYALT------QLYGSAPGFAMEELSGESLNRKLQLCEELLKL-----ADIFDGGWSIFR 459
            :.|:....|:      |.:..|..:|.:.:.|            .|||     |.:   |.:..|
Zfish   346 YYLRVCCTLSEVLSYLQFFDEASEYARKMVDG------------YLKLYHPNNAQL---GMATMR 395

  Fly   460 GNL------LIDMEEALVTQALR------------SKDPLDCEEKLRNAAEMLREIRNIMKHE-- 504
            ..:      .|::...::.:|..            :||    .|.:|...||  |:|...::|
Zfish   396 AGVTHWQAGFIEVAHGMICKAFAILMITHGPTHPITKD----LEAMRMQTEM--ELRMFQQNEYV 454

  Fly   505 -PEMQQLLLERQVILSSALERFEPVEN 530
             ..|::..|:.|.:...|....|.::|
Zfish   455 YHSMREAALKNQPMRMMAEPTNEGIKN 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SmydA-2	NP_649084.1	zf-MYND	9..46	CDD:280009
SmydA-2	NP_649084.1	SET	<246..291	CDD:214614	13/57 (23%)
smyd1b	NP_001034725.1	zf-MYND	47..85	CDD:280009	10/44 (23%)
smyd1b	NP_001034725.1	SET	<173..247	CDD:214614	17/73 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I11197
eggNOG	1	0.900	-	-		E2759_KOG2084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D981799at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820