DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SmydA-2 and SmydA-6

DIOPT Version :9

Sequence 1:	NP_649084.1	Gene:	SmydA-2 / 40075	FlyBaseID:	FBgn0036839	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_611182.1	Gene:	SmydA-6 / 36917	FlyBaseID:	FBgn0034183	Length:	498	Species:	Drosophila melanogaster

Alignment Length:	517	Identity:	141/517 - (27%)
Similarity:	225/517 - (43%)	Gaps:	104/517 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 EIATNEVLGRHLRATRDIKIGEQILKEAPLVLGPKVASAPLCLGCHRNLLAPGKPRGNYHKCSSC 114
            ||..|:.|||...|..:::.||.:|.|.|:|:.|.:..                     .:||.|
  Fly    13 EIKQNDTLGRFAVALCNVRAGETLLLENPIVVLPLMGE---------------------RRCSKC 56

  Fly   115 ---SWPLCGK-----ECED-SVHHKAECQLMSGSNFQSKINYVPGEEERKESAYCVIMLLRCMHL 170
               :...|.|     .||| |.|.:.:|:.::..||......:..::|..|    :..:|:|:.|
  Fly    57 FNLTESFCRKCRLLALCEDCSDHDERDCKRLAEMNFSDDQVELLQKKEHTE----IQPVLKCLLL 117

  Fly   171 KDKDPDAFLKLY----NLEDHLKERLETPLYQVLRANLIT---FIKTVLGMKDWPEMDILR-IAA 227
            ::.:..  |.||    .::..|..|..|.:::..:.:..|   :...:..::...:.|::: :..
  Fly   118 REHEET--LPLYEEMSQMDSQLMTRRGTEVWKNYQEHAFTPLDYGGVLAQLRGAADEDLVQGLLG 180

  Fly   228 ILDTNTFEVRQPRERRKIRALYPGAAMISHDCVPNMRHRFDDDMNIVFLAKRKIAKGEILSISYT 292
            |||.|.:|:|.|.....:|.||..|.:.:|.|.||:....||:..|...|.|.||.||||...||
  Fly   181 ILDINAYEIRAPEVGGAMRGLYRRAGLFAHSCTPNLVISIDDEQRIKVYANRFIAAGEILYNCYT 245

  Fly   293 QPLRSTIQRRVHLRQAKCFDCSCARCQDPEELGSFAGAQTCLKCKA--GKIISLNPLLNSAPWKC 355
            ..|..|.:||..|:..|||||||.|||||.|||:...:..|.:|..  |.|:. .|  ::..|:|
  Fly   246 NVLLGTEERRKILKVGKCFDCSCPRCQDPTELGTHMSSFICSQCSCVDGYIVR-QP--DTGIWQC 307

  Fly   356 QL-----------CNFKRSAKDVV--TSDAELQQELESLDKTTPVALEEFIYRHR---ADLHETN 404
            .|           .|....||:.:  ..|...:||| .|.|     |...::|:.   .||.:..
  Fly   308 LLNPEHTLKQEFVSNMLERAKEEIFHARDDIYRQEL-LLAK-----LSRLLHRNHFLMLDLKQNI 366

  Fly   405 THILQAKYALTQLYGSAPGFAMEELSGESLNRKLQLCEELLKLADIFDGGWSIFRGNLLIDMEEA 469
            ..||:   .:.|..|:.|...:.|       ||::||:|:|.:..:...|.|..:.   |.:.|.
  Fly   367 ASILR---QILQNMGTRPNKKVYE-------RKIRLCQEILLVLKVVTPGISRLKA---IALYEL 418

  Fly   470 LVTQALRSKDPLDCEEKLRNAAEMLREIRNIMKHEPEMQQLLLER-QVILSSALER--FEPV 528
            ..||                 ||:.|::...|:|........||| :|:|..:|..  |||:
  Fly   419 ANTQ-----------------AELARKMYTEMEHSANDLLAELERVEVMLRESLRMLLFEPL 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SmydA-2	NP_649084.1	zf-MYND	9..46	CDD:280009
SmydA-2	NP_649084.1	SET	<246..291	CDD:214614	19/44 (43%)
SmydA-6	NP_611182.1	SET	<179..244	CDD:279228	26/64 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	77	1.000	Inparanoid score	I1875
Isobase	1	0.950	-	0	Normalized mean entropy	S4564
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D981799at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR46455
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2203
	7	6.920