DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SmydA-2 and Smyd4-3

DIOPT Version :9

Sequence 1:	NP_649084.1	Gene:	SmydA-2 / 40075	FlyBaseID:	FBgn0036839	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_725048.1	Gene:	Smyd4-3 / 36234	FlyBaseID:	FBgn0033633	Length:	660	Species:	Drosophila melanogaster

Alignment Length:	482	Identity:	115/482 - (23%)
Similarity:	165/482 - (34%)	Gaps:	155/482 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 IATNEVLGRHLRATRDIKIGEQILKEAPL--VLGPKVASAPLCLGCHRNLLAPGKPRGNYHKCSS 113
            |.:|...||..||:.|:|.||::|.|.|.  ||..|.|... |..|....:.|       ..|..
  Fly   243 IDSNRQEGRFARASADVKPGEELLVERPFVSVLLEKFAKTH-CENCFMRTVVP-------VACPR 299

  Fly   114 CSWPL-CGKECEDSV---HHKAECQLM-----SGSNFQSKINYVPGEEERKESAYCVIMLLRCMH 169
            |:..| |.::|.:..   :||.||.::     ||::..:.|                  .||.:.
  Fly   300 CADVLYCSEQCREEASKKYHKYECGIVPIIWRSGASINNHI------------------ALRIIA 346

  Fly   170 LKDKD----------------------PDAFLKLYNLEDHLKERLETPLYQ-VLRANLITFIKTV 211
            .|..|                      .|.|.::..||.|..||..:..:| ||.|..:|.....
  Fly   347 SKPLDYFLKLKPTIDEELTPEQLISLPKDDFRRVAQLERHQGERQPSNFFQHVLMARFLTNCLRA 411

  Fly   212 LG-MKDWPEMD--------ILRIAAILDTNTFEVRQ-------PRERRKI--RALYPGAAMISHD 258
            .| ....|:.|        :||....:..||.||.:       .||:...  .|:||..|:.:|.
  Fly   412 GGYFGSEPKPDEVSIICSLVLRSLQFIQFNTHEVAELHKFSSSGREKSIFIGGAIYPTLALFNHS 476

  Fly   259 CVPNMRHRFDDDMNIVFLAKRKIAKG----EILSISYTQPLRSTIQRRVHLRQAKCFDCSCARCQ 319
            |.|.: .|:.....|...:.|.|..|    |.....|||..||  :|:..|:....|:|||..|.
  Fly   477 CDPGV-VRYFRGTTIHINSVRPIEAGLPINENYGPMYTQDERS--ERQARLKDLYWFECSCDACI 538

  Fly   320 D--------PEELGSFAGAQTCLKCKA----GKIISLNPLLNSAPWKCQLC----NFKRSAKDVV 368
            |        |.::..|       :|.|    ..:|.:.|..|....||..|    |..:..|
  Fly   539 DNWPKFDDLPRDVIRF-------RCDAPNNCSAVIEVPPSCNDFMVKCVTCGEITNILKGLK--- 593

  Fly   369 TSDAELQQELESLDKTT---------PVALEEFIYRHRADLHETNTHILQAKYALTQLYGSAPGF 424
                 :.|:.|.:.:|.         |.||.:|:     ||......:|            ||.|
  Fly   594 -----VMQDTEMMTRTAKRLYETGEYPKALAKFV-----DLIRIMYEVL------------APPF 636

  Fly   425 AMEELSGESLNRKLQLCEELLKLADIF 451
            .             ..||....|.|.|
  Fly   637 P-------------DFCESQQHLKDCF 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SmydA-2	NP_649084.1	zf-MYND	9..46	CDD:280009
SmydA-2	NP_649084.1	SET	<246..291	CDD:214614	13/48 (27%)
Smyd4-3	NP_725048.1	TPR_11	74..143	CDD:290150
		TPR repeat	74..103	CDD:276809
		TPR repeat	108..142	CDD:276809
		TPR repeat	150..177	CDD:276809
		zf-MYND	284..323	CDD:280009	10/45 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810