DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SmydA-2 and SmydA-5

DIOPT Version :9

Sequence 1:	NP_649084.1	Gene:	SmydA-2 / 40075	FlyBaseID:	FBgn0036839	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_610202.3	Gene:	SmydA-5 / 35538	FlyBaseID:	FBgn0033061	Length:	553	Species:	Drosophila melanogaster

Alignment Length:	546	Identity:	169/546 - (30%)
Similarity:	258/546 - (47%)	Gaps:	75/546 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SLTSCALCQAKASQLCAACRNVVYCSREHQKEHWKKGHRSECQCFEIATNEVLGRHLRATRDIKI 69
            |.|.|.:|...|||.|..|:.|.||.|||||:||.: |:..|:.|....:..|||:|:.|::|..
  Fly     3 SSTECPVCGVAASQACTRCKMVRYCDREHQKQHWPQ-HKRRCRPFSEEQDAELGRYLKVTQNIAA 66

  Fly    70 GEQILKEAPLVLGP--------KVASAPLCLGCHRNLLAP---GKPRGNYHKCSSCSWPLCGKEC 123
            |:.:..|.|||:||        |.||...|:||:    .|   ||     |:|..|.||:|...|
  Fly    67 GQIVFIEEPLVVGPKWYLSDADKEASNVPCVGCY----TPCRLGK-----HQCRRCRWPVCSAGC 122

  Fly   124 EDSVHHKAECQLM---SGS----NFQSKINYVPGEEERKESAYCVIMLLRCMHLKDKDPDAFLKL 181
            :   |...||.::   |||    :.:|..:|..|:         .:::|:|:.|:.:.|..:..|
  Fly   123 K---HESMECSVLSLGSGSPTRADARSLNDYFRGD---------ALLVLKCLLLQRQSPTKWSAL 175

  Fly   182 YNLEDHLKERLETPLYQVLRANLITFIK---------------TVLGMKDWPEMDILRIAAILDT 231
            ..::.|.:||..|.||:.....::|:::               |..|    ||| :.|:..|::|
  Fly   176 LEMQSHEEERKGTDLYEEAEKRVVTYLQKRFLCRLKQTNPNLLTDCG----PEM-LHRLCGIIET 235

  Fly   232 NTFEVRQPRERRKIRALYPGAAMISHDCVPNMRHRFDD-DMNIVFLAKRKIAKGEILSISYTQPL 295
            |...:..| ...::..|:..|.|:.|.|.||...:||: ...:...|...:.||:.|.|:||..|
  Fly   236 NFMVIELP-SGVELSGLFRQACMMEHACQPNCDFQFDNKTQQVAVRAGCDLRKGDHLRITYTNIL 299

  Fly   296 RSTIQRRVHLRQAKCFDCSCARCQDPEELGSFAGAQTCL-----KCKAGKIISLNPLLNSAPWKC 355
            ..|..|:.|||..|.|.|.|:||.||.|.|::..|.|||     .| .|..:.::||..:..|||
  Fly   300 WGTQLRQHHLRLTKHFSCRCSRCLDPTEYGTYISALTCLGDVNQTC-GGTHLPVDPLDENTQWKC 363

  Fly   356 QLCNFKRSAKDVVTSDAELQQELESLDKTTPVA--LEEFIYRHRADLHETNTHILQAKYALTQLY 418
            ..|........|....:.:.:::|.|....|.|  :|..:.|....||..:.|....|:.|.|||
  Fly   364 DTCPMIVDGAYVAELQSHMTEQVEGLLAGCPSANQVELLLARLTHMLHPNHFHTFNLKHTLIQLY 428

  Fly   419 GSAPGFAMEELSGESLNRKLQLCEELLKLA---DIFDGGWSIFRGNLLIDMEEALVTQALRSKDP 480
            |:..|..:..||...|.|||:||.||..:.   |.:....:|:...:||::...|..||.|:  |
  Fly   429 GNEAGLELGVLSNTQLERKLRLCGELYNVCRRLDPYSIKLAIYVTVILIEVAHTLQEQARRA--P 491

  Fly   481 LDCEEKLRNAAEMLREIRNIMKHEPE 506
            .:....|..|...|||...:::.|.|
  Fly   492 AEGTSLLGLAQSRLREAHMVLEKEQE 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SmydA-2	NP_649084.1	zf-MYND	9..46	CDD:280009	18/36 (50%)
SmydA-2	NP_649084.1	SET	<246..291	CDD:214614	14/45 (31%)
SmydA-5	NP_610202.3	zf-MYND	7..43	CDD:280009	18/36 (50%)
SmydA-5	NP_610202.3	SET	185..295	CDD:279228	29/115 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	60	1.000	Domainoid score	I3856
eggNOG	1	0.900	-	-		E2759_KOG2084
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	77	1.000	Inparanoid score	I1875
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47470
OrthoDB	1	1.010	-	-		D981799at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR46455
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2203
	8	7.980