DRSC/TRiP Functional Genomics Resources

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Protein Alignment SmydA-2 and Smyd4

DIOPT Version :10

Sequence 1:NP_649084.1 Gene:SmydA-2 / 40075 FlyBaseID:FBgn0036839 Length:530 Species:Drosophila melanogaster
Sequence 2:NP_001099280.1 Gene:Smyd4 / 287525 RGDID:1307369 Length:801 Species:Rattus norvegicus


Alignment Length:611 Identity:132/611 - (21%)
Similarity:212/611 - (34%) Gaps:183/611 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    51 IATNEVLGRHLRATRDIKIGEQILKEAPL--VLGP----------------KVASAPL-CLGCHR 96
            :.|:.:.||||.||:||..||.::||...  ||.|                :|.||.| |..|.|
  Rat   237 LCTDPLKGRHLVATKDILPGELLVKEDAFVSVLNPGEMPPLRHCLENKWDTRVTSADLYCHRCLR 301

  Fly    97 NLLA--PGKPRGNYHKCSSCSW-PLCGKECEDSV---HHKAECQ--------------------- 134
            :.||  |         |..||: ..|.:||....   :|..||.                     
  Rat   302 HTLATVP---------CGGCSYAKYCSQECVQQAWDHYHSTECSLGGLLLTLGVFCHVALRMTLL 357

  Fly   135 -----------------------LMSGSNFQSKINYVPGEEERKESAYCVIMLLRC-MHLK-DKD 174
                                   |....:......|....|..:.|..|...:..| ::.| :.:
  Rat   358 ARFEDVDRVIRMICDKTGRKDTCLPESKDLVKTFGYTNQGESEENSETCEPSIPGCNVNGKYENN 422

  Fly   175 PDAFLKLY-NLEDHLKER--------------------------LETPLYQVLRANLITFIKTVL 212
            .||.|.|. :.|.|..|.                          |::|..:.:...|.|.: ||.
  Rat   423 YDAVLSLLPHTEKHSPEHKFICAVSVSALCRQLKATSLQAQTTGLKSPRLKAVTPGLCTDL-TVW 486

  Fly   213 GMKDWPEMDILR-----IAAILDTNTFE--VRQPRERRKIRALYPGAAMISHDCVPNMRHRFDDD 270
            |:.....|..|:     |.:|....:.|  :...|:.|....::|..::::|.|.||....|...
  Rat   487 GVAMLQHMLQLQCNAQAITSICYAGSKESIITNSRQVRLATGVFPVVSLLNHSCSPNTSVSFTST 551

  Fly   271 MNIVFLAKRKIAKG-EILSISYTQPLRSTI-QRRVHLRQAKCFDCSCARCQDPEELGSFAGAQTC 333
            :..: .|.::|||| |||........|..: :|:..|.....|||||..|.......:.|.....
  Rat   552 VATI-RAAQQIAKGQEILHCYGPHESRMGVAERQQRLSSQYFFDCSCPACHAETLRAAVAPRWEA 615

  Fly   334 LKCKAGKIISLNPLLNSAPWKC--QLCNFKRSAKDVVTSDAELQQELESLDK-----TTPVALEE 391
            ..|...::    |:..:....|  :.|....|...:|:...:|||::.:..|     ....|:::
  Rat   616 FCCNTCRV----PMQGNDVLSCSNESCTNSVSRDRLVSRLQDLQQQVHTAQKLLRSDRPEQAIQQ 676

  Fly   392 FIYRHRAD---LHETNTHILQAKYALTQLYGSAPGFAMEELSGESLNRKLQLCE----------- 442
            .:...||.   |...:|.:.:.:..|.|.|.:...:..   |...:.:.||:.|           
  Rat   677 LLECQRAAENFLSAEHTVLGEIEDGLAQAYATLGDWRQ---SAAHVQKSLQVVEARHGPSSVEIG 738

  Fly   443 -ELLKLADIFDGGWSIFRGNLLIDMEEALVTQALRSKDPLDCEEKLRNAAEMLREIRNIMKH--- 503
             ||.|||.:      :|.|   :.:.|||        |.:...||:            ::.|   
  Rat   739 HELFKLAQV------LFNG---LAVPEAL--------DAIWKAEKI------------LLVHCGP 774

  Fly   504 -EPEMQQLLLERQVILSSALERFEPV 528
             ..|:|:|...|..:|.|:   |.||
  Rat   775 ESDEVQELREMRSCLLDSS---FTPV 797

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SmydA-2NP_649084.1 zf-MYND 9..46 CDD:460312
SET_SMYD <227..318 CDD:380997 26/94 (28%)
Smyd4NP_001099280.1 3a0801s09 7..>211 CDD:273380
TPR repeat 68..96 CDD:276809
TPR repeat 101..136 CDD:276809
SET 239..>269 CDD:394802 13/29 (45%)
zf-MYND 296..335 CDD:460312 13/47 (28%)
SET_SMYD4 418..600 CDD:380934 44/183 (24%)
TPR_12 661..728 CDD:315987 12/69 (17%)
Blue background indicates that the domain is not in the aligned region.

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