DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SmydA-2 and set-14

DIOPT Version :9

Sequence 1:	NP_649084.1	Gene:	SmydA-2 / 40075	FlyBaseID:	FBgn0036839	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_496323.1	Gene:	set-14 / 174662	WormBaseID:	WBGene00011068	Length:	429	Species:	Caenorhabditis elegans

Alignment Length:	522	Identity:	110/522 - (21%)
Similarity:	186/522 - (35%)	Gaps:	149/522 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 CALCQAKASQL--CAACRNVVYCSREHQKEHWKKGHRSECQCFEIATNEVLGRHLRATRDIKIGE 71
            |..|....::|  |:|||.:.|||:|.|:..||. |:.||:..: ..|||....:|
Worm    26 CNQCLTSMAELKKCSACRRLAYCSQECQRADWKL-HKVECKAIK-THNEVANDSIR--------- 79

  Fly    72 QILKEAPLVLGPKVASAPLCLGCHRNLLAPGKPRGNYHKCSSCSWPLCGKECEDSVHHKAECQLM 136
                   ||:  ::|               ||...|                ||.   :.|...:
Worm    80 -------LVM--RIA---------------GKLSRN----------------EDG---EIEAYYI 101

  Fly   137 SG--SNFQSKINYVPGEEERKESAYCVIMLLRCMHLKDKDPDAFLKLYNLEDHLKERLETPLYQV 199
            .|  .|||:.        |...|:|            |.|.::|:|.|              :|
Worm   102 PGVARNFQNL--------EHHPSSY------------DADEESFVKEY--------------FQ- 131

  Fly   200 LRANLITFIKTVLGMKDWPEMDILR-IAAILDTNTFEVRQPRERRKIRALYPGAAMISHDCVPNM 263
                        ..:...|:.|::: |...:..|:|.|...........|....:..:|.|.|..
Worm   132 ------------FAIAPHPDRDLIKLIFQKVSINSFVVGNSTGNPIGVGLCIKLSAANHSCKPLT 184

  Fly   264 R--HRFDDDMNIVFLAKRKIAKGEILSISYTQPLRSTIQRRVHLRQAKCFDCSCARCQDPEELGS 326
            |  :|....| :|.::....:..|....||...|.....||..|::...|.|.|..|.| |:..:
Worm   185 RVCYRNRTAM-LVPVSSELPSTLEGACHSYIDELMPRDMRRDTLKKKYKFLCQCDGCLD-EDRNA 247

  Fly   327 FAGAQTCLKCKAGKIISLNPLLNSAPWKCQLCNFK---------RSAKDV-VTSDAELQQELESL 381
            ...|.||..|..|.      :.|....:|:||.:.         |:|::. :.:.:.|..:...|
Worm   248 RMEAWTCGICVKGW------MRNKENGQCELCGWTMSKDHFELCRTAEEAGIAARSRLANDAIPL 306

  Fly   382 DKTTPVALEEFIYRHRADLHETNTH---ILQAKYALTQLYGSAPGFAMEELSGESLNRKLQLCE- 442
            : |.....|:.:...:..||:.|.|   :|:..|..:.   :|........:|.:|...:.:.:
Worm   307 E-TKRNLCEKLLDLFQDTLHDHNVHRIPVLRCLYICSL---AAQNITAAAKTGGTLLSIMLVYQN 367

  Fly   443 --------ELLKLADIF-DGGWSIFRGNLLIDMEEALVTQALRSKDPLDCEEKLRNAAEMLREIR 498
                    :..:||.:| ..|.......||.::||.|  :.:.:.|.:.|    ||...|:.:.|
Worm   368 TTDPAILFQKYQLAQLFCAAGAKTQATKLLQEIEEPL--EKIYTPDSMIC----RNVYCMILKAR 426

  Fly   499 NI 500
            |:
Worm   427 NL 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SmydA-2	NP_649084.1	zf-MYND	9..46	CDD:280009	15/38 (39%)
SmydA-2	NP_649084.1	SET	<246..291	CDD:214614	9/46 (20%)
set-14	NP_496323.1	zf-MYND	26..64	CDD:280009	15/38 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D981799at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820