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Protein Alignment SmydA-2 and SMYD4

DIOPT Version :9

Sequence 1:	NP_649084.1	Gene:	SmydA-2 / 40075	FlyBaseID:	FBgn0036839	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_443160.2	Gene:	SMYD4 / 114826	HGNCID:	21067	Length:	804	Species:	Homo sapiens

Alignment Length:	594	Identity:	120/594 - (20%)
Similarity:	208/594 - (35%)	Gaps:	184/594 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 CALC--QAKASQLCAACRNVVYCSREHQKEHWKKGHRSECQCFEIATNEVLGRHLRATRDIKIGE 71
            |..|  ...|:..|..|....|||:|..::.|:..||:||....:.....:..|:.....:.:|.
Human   296 CHRCLKHTLATVPCDGCSYAKYCSQECLQQAWELYHRTECPLGGLLLTLGVFCHIALRLTLLVGF 360

  Fly    72 QILKEAPLVLGPKVASAPLCLGCHRNL-------LAPGKPRGNYHKCSSCSWPLCGKECEDSVHH 129
            :.:::....|..|:::..:||....|.       |...:..||.     ...|:.|  |:  ::.
Human   361 EDVRKIITKLCDKISNKDICLPESNNQVKTLNYGLGESEKNGNI-----VETPIPG--CD--ING 416

  Fly   130 KAECQLMSGSNFQSKINYVPGEEERKES-----AYCVIMLLRCMHLKDKDPDAFLKLYNLEDHLK 189
            |.|      :|:.:..|.:|..|.....     |.||..|.|
Human   417 KYE------NNYNAVFNLLPHTENHSPEHKFLCALCVSALCR----------------------- 452

  Fly   190 ERLETPLYQVLRANLI---TFIKTVLGMKDWPEMDILRIAAI-----LDTN-----TFEVRQPR- 240
             :||....|.:....|   :.:|..:..:..|::.|..:|.:     |..|     |.:...|:
Human   453 -QLEAASLQAIPTERIVNSSQLKAAVTPELCPDVTIWGVAMLRHMLQLQCNAQAMTTIQHTGPKG 516

  Fly   241 ----ERRKIR---ALYPGAAMISHDCVPNMRHRFDDDMNIVFLAKRKIAKGEILSISYTQPLRST 298
                :.|::|   .::|..::::|.|.||....|...:..: .|.::|.||:.:...| .|.:|.
Human   517 SIVTDSRQVRLATGIFPVISLLNHSCSPNTSVSFISTVATI-RASQRIRKGQEILHCY-GPHKSR 579

  Fly   299 I---QRRVHLRQAKCFDCSCARCQDPEELGSFAG----AQTCLKCKAGKIISLNPLLNSAPWKCQ 356
            :   :|:..||....|||:|..|| .|.....||    |..|..|.|       |:......:|.
Human   580 MGVAERQQKLRSQYFFDCACPACQ-TEAHRMAAGPRWEAFCCNSCGA-------PMQGDDVLRCG 636

  Fly   357 LCNFKRSAKDVVTSDAELQQELESLDKTTPVA----------------------LEEFIYRHRA- 398
                .||..:...|...|...|:.|.:...||                      .|.|::...|
Human   637 ----SRSCAESAVSRDHLVSRLQDLQQQVRVAQKLLRDGELERAVQRLSGCQRDAESFLWAEHAV 697

  Fly   399 ----------------DLHETNTHILQAKYALTQLYGSAPGFAMEELSGESLNRKLQLCEELLKL 447
                            |..::.||:.::.|.:...:|.:               .:::..||.||
Human   698 VGEIADGLARACAALGDWQKSATHLQRSLYVVEVRHGPS---------------SVEMGHELFKL 747

  Fly   448 ADIFDGGWSIFRGNLLIDMEEALVTQALRSKDPLDCEEKLRNAAEMLR--------EIRNIMKHE 504
            |.||..|:::         .|||.|              ::.|.|:|.        ||:.:.|
Human   748 AQIFFNGFAV---------PEALST--------------IQKAEEVLSLHCGPWDDEIQELQK-- 787

  Fly   505 PEMQQLLLE 513
              |:..||:
Human   788 --MKSCLLD 794

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.