DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SmydA-2 and smyd1

DIOPT Version :9

Sequence 1:	NP_649084.1	Gene:	SmydA-2 / 40075	FlyBaseID:	FBgn0036839	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	XP_012811600.1	Gene:	smyd1 / 100145429	XenbaseID:	XB-GENE-978314	Length:	491	Species:	Xenopus tropicalis

Alignment Length:	566	Identity:	111/566 - (19%)
Similarity:	193/566 - (34%)	Gaps:	175/566 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 EIATNEVLGRHLRATRDIKIGEQILKEAPLVLGPKVA-------SAPLCLGCHRNLLAPGKPRGN 107
            ||..:|..||.|||.|:...|:.|..|      |..:       |..:|..|.       |.:..
Frog     5 EIFESEGKGRGLRAIRESWAGDIIFAE------PAYSAVVFDNLSHSVCHSCF-------KRQEK 56

  Fly   108 YHKCSSCSWP-LCGKEC--EDSVHHKAECQLMSGSNFQSKINYVPGEE-----------ERKESA 158
            ..:|..|.:. .|.:.|  |...:||.||..:      .|....|.|.           ||:.|.
Frog    57 LLRCGQCKFAHYCDRTCQKESWANHKNECVAI------KKAGKAPNENIRLAARILWRIEREGSG 115

  Fly   159 Y---CVIMLLRCMHLKDKDPDAFLKLYNLEDHLKERLETPLYQVLRANLITFIKTVLGMKDWPEM 220
            .   |::                 .:.:|::|: ::.:.....:|..::..|::.      ||..
Frog   116 LTEGCLV-----------------SIDDLQNHI-DKFDEAEKGLLMEDVQKFLEY------WPSQ 156

  Fly   221 D-------ILRIAAILDTNTFEVRQPRERRKIR-ALYPGAAMISHDCVPN------------MRH 265
            .       |..|.:::..|.|.:...|..:.:. .::|...:.:|||.||            :|.
Frog   157 SQQFGMQYISHIFSVISCNGFTLSDQRGLQAVGVGIFPNLCLANHDCWPNCTVIFNNGNHEAVRS 221

  Fly   266 RFDDDMNIVFLAKRKIAKGEILSISYTQPLRSTIQRRVHLRQAKCFDCSCARCQDPEELGSFAGA 330
            .|...|.|...|..||.|||.|::||...|..|..|:..|::...|||:|..|..
Frog   222 MFHTQMRIELRALGKINKGEELTVSYVDFLNLTEDRKAQLKKQYYFDCTCEHCTK---------- 276

  Fly   331 QTCLKCKAGKIISLNPLLNSAPWKCQLCNFKRSAKDVVTSDAELQQELESLDKTTPVALEEFIYR 395
                |.|...::::....:...        :|..|:|:....:..:::|.       |..|.:|.
Frog   277 ----KTKDALLLAVKDGEDKPE--------ERVVKEVIQYSKDTMEKIEK-------ARSEGLYN 322

  Fly   396 HRADLHETNTHILQAKYALTQLYGSAPGFAMEELSGESLNRKLQLCEELLKLADIFDG------- 453
            ....|........:..:|.|.:|               :.|.|.:..|:|....:||.
Frog   323 DVVKLCRDCLKRQEPIFADTNIY---------------MLRILSIYSEVLSYLQMFDDAAENAKK 372

  Fly   454 ----------------GWSIFRGNL------LIDMEEALVTQA----LRSKDPL-----DCEEKL 487
                            |.::.|..:      :|::...::.:|    |.:..||     |. |.:
Frog   373 MVDGYLKIYHQNNAQLGMAVMRAGVTHWHAGMIEVGHGMICKAFAILLITHGPLHPITKDL-EVM 436

  Fly   488 RNAAEMLREIRNIMKHE---PEMQQLLLERQVILSSALERFEPVEN 530
            |...||  |:|...::|   .:|::..|..:..........||..|
Frog   437 RAQTEM--ELRMFKENEFVYYKMREAALSNKPFQVMKEPNSEPATN 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SmydA-2	NP_649084.1	zf-MYND	9..46	CDD:280009
SmydA-2	NP_649084.1	SET	<246..291	CDD:214614	17/57 (30%)
smyd1	XP_012811600.1	zf-MYND	47..85	CDD:280009	10/44 (23%)
smyd1	XP_012811600.1	SET	<189..252	CDD:214614	19/62 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D981799at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010