DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3808 and TRM2

DIOPT Version :9

Sequence 1:	NP_649083.2	Gene:	CG3808 / 40074	FlyBaseID:	FBgn0036838	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_012982.2	Gene:	TRM2 / 853930	SGDID:	S000001764	Length:	639	Species:	Saccharomyces cerevisiae

Alignment Length:	612	Identity:	137/612 - (22%)
Similarity:	231/612 - (37%)	Gaps:	156/612 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 IETEEISENVVKADETTLANGEDEAGKAGEEYAYLERNEFTSEIFKVEVKNMGYFGI---GEFKK 78
            ::::.:|...|..|.|::.|  |::...|.......|          ||||:....|   |....
Yeast   133 LKSQNLSREQVLNDVTSILN--DKSSTDGPIVLQYHR----------EVKNVKVLEITSNGNGLA 185

  Fly    79 LLRNTLKFDVTKIKAPTRKEFAFVCFRSQEDQQRALEILNGYKWKGKVLKAHVAKASADPLQKKR 143
            |:.|.::.:        :|:...:.|....|      ::|     .||.|.|.....:|.|
Yeast   186 LIDNPVETE--------KKQVVIIPFGLPGD------VVN-----IKVFKTHPYYVESDLL---- 227

  Fly   144 AAEEQESERKPKKQRTAV-------EATCPLSHIAYDQQIKQKSEEMSALLAKYTQEL--RKVNP 199
                ...|:.|.::...:       .:...|..:.||.|::.|.:.:......:...|  .|:.|
Yeast   228 ----DVVEKSPMRRDDLIRDKYFGKSSGSQLEFLTYDDQLELKRKTIMNAYKFFAPRLVAEKLLP 288

  Fly   200 RAKPHLDKFQFHEVLPSPTVNGYRNK--NEFTVGKNSVGEVVVGFRLGCYSDGSVEVAEVADLPH 262
                     .|...:.||...|||.|  ..|.:.|....|:.|...||....|
Yeast   289 ---------PFDTTVASPLQFGYRTKITPHFDMPKRKQKELSVRPPLGFGQKG------------ 332

  Fly   263 LPEQAKWAARSFQDLVRKSKFLPFNPDGNIGHFRQLMVRCSSATGELMLVAGIYSSNLSEDEQVE 327
               :.:|         ||...       :||....::     ...|.:|...:.:..|: :|:.:
Yeast   333 ---RPQW---------RKDTL-------DIGGHGSIL-----DIDECVLATEVLNKGLT-NERRK 372

  Fly   328 LKQELKSF-------------------------YEDLANDAPYKCSSLYYQDVKH--REAGQTIN 365
            .:||.|::                         .|:.:.|.....|.:..:|.|:  |.|...:.
Yeast   373 FEQEFKNYKKGATILLRENTTILDPSKPTLEQLTEEASRDENGDISYVEVEDKKNNVRLAKTCVT 437

  Fly   366 PVEHISGSTHITDTIQGLQFRISPLAFFQINTEGANVLYQKAID-LVAPTKDTT-----MLDICC 424
            ....|     :|:.:.|..|..|...|||.|.....::.:...| |.||.|...     ::|..|
Yeast   438 NPRQI-----VTEYVDGYTFNFSAGEFFQNNNSILPIVTKYVRDNLQAPAKGDDNKTKFLVDAYC 497

  Fly   425 GTGTITLAFAKHCKKVMGVEIVPDAIKDAEFNAEANGIKNAKFFTGNADDFIKSMVREALYDQEP 489
            |:|..::..:|...||:||||..|::..||.||:|||::|.:|..|.|:...:|:       ..|
Yeast   498 GSGLFSICSSKGVDKVIGVEISADSVSFAEKNAKANGVENCRFIVGKAEKLFESI-------DTP 555

  Fly   490 GKPLDLIAVVDPPRAG---LHHRSIAAIRSADAINRLVYVSCNPHSAKRNFIELARPESKQYKGE 551
            .:...:|  :||||.|   |..:.:||...|    :::|:|||.||..|: :|....|::  .|.
Yeast   556 SENTSVI--LDPPRKGCDELFLKQLAAYNPA----KIIYISCNVHSQARD-VEYFLKETE--NGS 611

  Fly   552 PFYPKSAVAVDMFPHTMHTELVILFER 578
            ....:|....|.||.|.|.|.|.:.:|
Yeast   612 AHQIESIRGFDFFPQTHHVESVCIMKR 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3808	NP_649083.2	RRM_TRMT2A	56..134	CDD:240885	16/80 (20%)
		TrmA	57..571	CDD:225174	126/563 (22%)
		AdoMet_MTases	276..579	CDD:302624	86/339 (25%)
TRM2	NP_012982.2	TrmA	166..632	CDD:225174	127/569 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341369
Domainoid	1	1.000	86	1.000	Domainoid score	I1878
eggNOG	1	0.900	-	-		E1_COG2265
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4977
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001356
OrthoInspector	1	1.000	-	-		oto99266
orthoMCL	1	0.900	-	-		OOG6_100839
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1692
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.620