Protein Alignment CG3808 and TRMT2B

DIOPT Version :9

• Sequence 1: NP_649083.2
• Gene: CG3808 / 40074
• FlyBaseID: FBgn0036838
• Length: 615
• Species: Drosophila melanogaster
• Sequence 2: NP_001161442.1
• Gene: TRMT2B / 79979
• HGNCID: 25748
• Length: 504
• Species: Homo sapiens
• Alignment Length: 478
• Identity: 171/478 - (35%)
• Similarity: 262/478 - (54%)
• Gaps: 41/478 - (8%)

  Fly   124 GKVLKAHVAKASADPLQKKRAAEEQESERKPKK--------QRTAVEATCPLSHIAYDQQIKQKS 180
            |.|.|....:..|...||     .|:|::||..        |....:...||..::|::|:|.|.
Human    45 GTVCKGDFTRVIATKCQK-----GQKSQKKPSHLGPLDGSWQERLADVVTPLWRLSYEEQLKVKF 104

  Fly   181 EEMSALLAK---YTQELRKVN-PRAKPHLDKFQ--FHEVLPSPTVNGYRNKNEFTVGKNSVGE-V 238
            .....:|.:   |.|.|..|: ..|.|..::..  .|.::|||.:||||||:.|:|.:...|. .
Human   105 AAQKKILQRLESYIQMLNGVSVTTAVPKSERLSCLLHPIIPSPVINGYRNKSTFSVNRGPDGNPK 169

  Fly   239 VVGFRLGCYSDGSVEVAEVADLPHLPEQAKWAARSFQDLVRKSKFLPFNP-----DGNIGHFRQL 298
            .|||.||.:.||:|...:...|.::||:....|:.::..:|:|   |..|     :|  |::|:|
Human   170 TVGFYLGTWRDGNVVCVQSNHLKNIPEKHSQVAQYYEVFLRQS---PLEPCLVFHEG--GYWREL 229

  Fly   299 MVRCSSATGELMLVAGIYSSNLSEDEQVELKQELKSFYEDLANDAPYKCSSLYYQDVKHREAGQT 363
            .||.:| .|..|.:...:...||::|....|:.:|.|: .....|....:|||:|:.........
Human   230 TVRTNS-QGHTMAIITFHPQKLSQEELHVQKEIVKEFF-IRGPGAACGLTSLYFQESTMTRCSHQ 292

  Fly   364 INPVEHISGSTHITDTIQGLQFRISPLAFFQINTEGANVLYQKAIDLVAPTKDTTMLDICCGTGT 428
            .:|.:.:.|..:|.:.:..|:.||||.|||||||.||.:||:...:|.....||.:||||||||.
Human   293 QSPYQLLFGEPYIFEELLSLKIRISPDAFFQINTAGAEMLYRTVGELTGVNSDTILLDICCGTGV 357

  Fly   429 ITLAFAKHCKKVMGVEIVPDAIKDAEFNAEANGIKNAKFFTGNADDFIKSMVREALYDQEPGKPL 493
            |.|:.|:|..:|:|:|::..|::||.:.|..|||.|::|.||.|:..:..:::    .:|.|:
Human   358 IGLSLAQHTSRVLGIELLEQAVEDARWTAAFNGITNSEFHTGQAEKILPGLLK----SKEDGQ-- 416

  Fly   494 DLIAVVDPPRAGLHHRSIAAIRSADAINRLVYVSCNPH-SAKRNFIELARP--ESKQYKGEPFYP 555
            .::|||:|.|||||::.|.|||:..||:.||:|||..| .:.||.|||..|  .:|:..||||..
Human   417 SIVAVVNPARAGLHYKVIQAIRNFRAIHTLVFVSCKLHGESTRNVIELCCPPDPAKKLLGEPFVL 481

  Fly   556 KSAVAVDMFPHTMHTELVILFER 578
            :.||.||:||||.|.|||:||.|
Human   482 QQAVPVDLFPHTPHCELVLLFTR 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3808	NP_649083.2	RRM_TRMT2A	56..134	CDD:240885	3/9 (33%)
		TrmA	57..571	CDD:225174	165/469 (35%)
		AdoMet_MTases	276..579	CDD:302624	122/311 (39%)
TRMT2B	NP_001161442.1	TrmA	94..497	CDD:225174	152/415 (37%)
		AdoMet_MTases	<298..501	CDD:302624	94/208 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2265
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54357
OrthoDB	1	1.010	-	-		D248059at2759
OrthoFinder	1	1.000	-	-		FOG0001356
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1692
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.860