DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3808 and trmt2b

DIOPT Version :9

Sequence 1:	NP_649083.2	Gene:	CG3808 / 40074	FlyBaseID:	FBgn0036838	Length:	615	Species:	Drosophila melanogaster
Sequence 2:	NP_001116415.1	Gene:	trmt2b / 606657	ZFINID:	ZDB-GENE-050809-101	Length:	473	Species:	Danio rerio

Alignment Length:	461	Identity:	157/461 - (34%)
Similarity:	240/461 - (52%)	Gaps:	38/461 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 SADPLQKKRAAEEQESERKPKKQRTAV-------EATCPLSHIAYDQQIKQKSEEMSALLAKYTQ 192
            |..|::...|       :|||...|.:       :...||..:.|:.|::.|.|....:|.|..:
Zfish    34 SCKPVKTSNA-------KKPKLPTTKLSWEERLSDTVTPLWRMTYEDQLQWKYEHQKKILLKMMK 91

  Fly   193 ELRKVNPRA-KPHLDKFQFHEVLPSPTVNGYRNKNEFTVGKNSVGE-VVVGFRLGCYSDGSVEVA 255
            ||.:...|| ..||: |....::.||..:|||||:.|:|.|...|. ..:||.:|....|::...
Zfish    92 ELSQDPTRAFSDHLN-FPLLPIVASPVRDGYRNKSTFSVNKGIDGNPKTLGFYIGTGKAGNIVCV 155

  Fly   256 EVADLPHLPEQAKWAARSFQDLVRKSKFLPFNP-----DGNIGHFRQLMVRCSSATGELMLVAGI 315
            ....|..:|.:.|..||.::|.:|.|   |..|     ||  ||:|::.:|.:| ||..|.:...
Zfish   156 HADHLLSIPSKHKMVARCYEDFIRLS---PLRPCILFDDG--GHWREITIRTNS-TGHTMAIVYF 214

  Fly   316 YSSNLSEDEQVELKQELKSFYEDLANDAPYKCSSLYYQDVKHREAGQTINPVEHISGSTHITDTI 380
            :..:|:.:|....|..|..::.. ...|..:..|||:|:..........:..:.:.|.|||.:.:
Zfish   215 HPQSLTPEETDIHKAALVEYFTQ-GPGAICQLDSLYFQETTMTRCSHEQSQYQLLYGQTHIYEEV 278

  Fly   381 QGLQFRISPLAFFQINTEGANVLYQKAIDLVAPTKDTTMLDICCGTGTITLAFAKHCKKVMGVEI 445
            .|.:|||||.:|||:|.|.|..||:...:|..|....|:||:|||||.|.::.:...::|:|:|:
Zfish   279 LGFKFRISPDSFFQVNREAAEALYKTVAELSQPCVGGTLLDVCCGTGAIGISLSPQMERVIGIEL 343

  Fly   446 VPDAIKDAEFNAEANGIKNAKFFTGNADDFIKSMVREALYDQEPGKPLDLIAVVDPPRAGLHHRS 510
            :..|::||:|||..|.:.|.:|..|.|:..:..::.....|.      .|.|||:|.|||||:|.
Zfish   344 IEQAVEDAKFNAALNRVCNCEFLAGKAEVVLPDLMGSLSSDG------GLTAVVNPSRAGLHYRV 402

  Fly   511 IAAIRSADAINRLVYVSCNPH-SAKRNFIELARPES--KQYKGEPFYPKSAVAVDMFPHTMHTEL 572
            :.|:|:..||.||||:||.|. .|.|||.||.....  ::..||.|.|..||.||:||||.|.||
Zfish   403 VRALRNHSAIRRLVYISCKPDGEAMRNFRELCCSVGLVRRITGEAFKPVVAVPVDLFPHTPHCEL 467

  Fly   573 VILFER 578
            |::|||
Zfish   468 VLVFER 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3808	NP_649083.2	RRM_TRMT2A	56..134	CDD:240885
		TrmA	57..571	CDD:225174	151/452 (33%)
		AdoMet_MTases	276..579	CDD:302624	115/311 (37%)
trmt2b	NP_001116415.1	TrmA	69..466	CDD:225174	142/410 (35%)
trmt2b	NP_001116415.1	AdoMet_MTases	<267..471	CDD:302624	88/209 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54357
OrthoDB	1	1.010	-	-		D248059at2759
OrthoFinder	1	1.000	-	-		FOG0001356
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1692
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.960