DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18135 and CG9394

DIOPT Version :9

Sequence 1:	NP_788526.1	Gene:	CG18135 / 40073	FlyBaseID:	FBgn0036837	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	NP_001286660.1	Gene:	CG9394 / 37399	FlyBaseID:	FBgn0034588	Length:	679	Species:	Drosophila melanogaster

Alignment Length:	617	Identity:	229/617 - (37%)
Similarity:	353/617 - (57%)	Gaps:	35/617 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   173 FNVRLEVP----LAAEERLGLTGDVKALGEWQLSRSVALESLDELN-WQATVALQSCRQLEYRYF 232
            ||..|.:|    ||:.||..|.|::..||.||..|:|.|.....|| |.|:|.:.....:|||||
  Fly    54 FNFTLTLPDADQLASFERPALVGNLPVLGAWQAGRAVLLNRTAILNVWSASVEIPQNSSVEYRYF 118

  Fly   233 VYVEDLSGYKQIRRWETHFKPRSLGPCTELQCSQLDVFGITSDNSDLKPQVHRGWLNHEA-ILQL 296
            ......||..||||||:|.:.|:.. .|:...::.|.||:..:    :.|:.||||.... ||||
  Fly   119 AAAVGQSGAVQIRRWESHVQARTFN-TTKFSGNRSDEFGLIGN----ERQLSRGWLQDSGNILQL 178

  Fly   297 KFNGEKMFQVHDIETFDPQHVQLKIVPVE--------KTAGLHVEYSKQEYGKSQLELQPTFGVP 353
            |...|.: .:.:......:.::|::.||:        .:|..:|||.:..||.|:|.:||.:|||
  Fly   179 KLFREAL-SLEEQPEVGQEKLRLRLQPVDPKTLAPILSSARANVEYVRMAYGDSKLRVQPEYGVP 242

  Fly   354 YTKGDIVIFHITLPLERMMEQHFRLECYSMSNE-----LLGSATLVTSDLTGSEGVLHLPIKSAK 413
            |..|||::||:.  ||::....:.:|.|:...:     |||.:.|:.:..:|:||.:.:.:.|..
  Fly   243 YATGDILMFHVN--LEQLDRVAYLVEVYAEQPDEDLVRLLGYSHLLHTSFSGTEGDVSIDLISPL 305

  Fly   414 NADETLARLRLPYVAVQPYRYSPLDFKNTYAHYWPKSWPNLDVGHRGNGKSYIADAPAER--ENT 476
             ....:.:||:.|:.::|......|.:.::|:||..:|..|::||||.|||......|..  |||
  Fly   306 -WQRVVGQLRIEYLHIRPMEKDGFDLRTSFANYWRSNWTALEIGHRGLGKSLTVTTNAAPLIENT 369

  Fly   477 IASFLSAHEHHADMIELDVHLTADGVPVIYHDFGLRTAPPGKQISRPDQLEYVLIKDINYELLKR 541
            :|:.|::.|..||::|.||.||:|.||:|:|||.:|.....|..:..|.|..||:|||:||.||.
  Fly   370 VATMLASSELGADLVEFDVQLTSDLVPIIHHDFSIRVCIDSKTPTSKDDLTEVLLKDISYEQLKD 434

  Fly   542 LRIFSVIAGQVREYPSHNAEPRMEHRIFPTLVEVLEKLPKSLGIDVEIKWPQRRQGGGSEAEQTI 606
            |:.:.::..::.|||:||.....|.|:||||.:..|::..|.|.|:||||||:|..|..|:|||:
  Fly   435 LKTYQIVGNKIVEYPAHNNVEPPEQRLFPTLQDFFERVNLSTGFDIEIKWPQQRADGLFESEQTL 499

  Fly   607 DKNFFADKVIHQVIQKGCGRPIIFSSFDADMCTMLRFKQNVFPVMFLTQGETKKWQPFLDLRTRT 671
            |||.|||:::..|.:.||||..:..|||||:|::|||||:::||:||:   :.|...|.|.||.|
  Fly   500 DKNLFADRILAVVRRHGCGRLNVIKSFDADLCSLLRFKQHMYPVLFLS---SSKENVFNDPRTST 561

  Fly   672 FIAAVNNAQAFELAGTAPHAEDFLGENASEMLRKAKDLGQIAVIWGDDCNSKERVQYFTRIGATA 736
            ...:||.||||:|.|.:|:|. |:..:.. ::::||....|.::||.|...:|.:.:|.:.|.|.
  Fly   562 VEQSVNFAQAFDLGGVSPNAV-FVKADPG-LVQRAKAQVPIVLLWGSDLKDRESIDWFLQQGPTG 624

  Fly   737 TCYDRSDLFMPEGKREAFFKSPALMAEFAAQC 768
            ..|||.||::...:..||.....|...|..||
  Fly   625 VIYDRLDLWLGANRTSAFEAEQDLPGYFQLQC 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18135	NP_788526.1	CBM20_Prei4	166..288	CDD:99888	44/119 (37%)
		GDPD_GDE5	454..741	CDD:176549	124/288 (43%)
		GDPD	458..744	CDD:281062	124/287 (43%)
CG9394	NP_001286660.1	CBM20	47..169	CDD:301601	44/119 (37%)
		GDPD_GDE5	345..630	CDD:176549	125/289 (43%)
		GDPD	349..632	CDD:281062	124/287 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45473128
Domainoid	1	1.000	104	1.000	Domainoid score	I2222
eggNOG	1	0.900	-	-		E1_COG0584
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3769
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D184242at33208
OrthoFinder	1	1.000	-	-		FOG0001717
OrthoInspector	1	1.000	-	-		mtm976
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22958
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1268
	10	9.800