Protein Alignment CG18135 and gde1

DIOPT Version :10

• Sequence 1: NP_788526.1
• Gene: CG18135 / 40073
• FlyBaseID: FBgn0036837
• Length: 770
• Species: Drosophila melanogaster
• Sequence 2: NP_001417947.1
• Gene: gde1 / 2543677
• PomBaseID: SPAPB1E7.05
• Length: 1135
• Species: Schizosaccharomyces pombe
• Alignment Length: 750
• Identity: 184/750 - (24%)
• Similarity: 296/750 - (39%)
• Gaps: 207/750 - (27%)

  Fly   117 LHSNPMAM----SRTVLILAVALSLQ---CAAFVDGASITYGTGNELESGSGSSAACKPTLREF- 173
            |.:||.|.    |.|.|:||.|..|.   ......|||:     :|::| ||.:|..:..:|.:
pombe   448 LGANPSARDFLNSWTPLMLASATGLSEIVSILVASGASV-----DEVDS-SGWTAMEQAVVRGYL 506

  Fly   174 ----NVRLEVPLAAEERLGL-TGDVKALG----------EWQLSRSVALESLDELNWQATVALQS 223
                .:|.:|.| :::.:.| |..:||..          :.||||||.:..:.:|..:..|:||.
pombe   507 HLADKLRTQVAL-SDKPVNLHTLYIKASSSEMRSRKRAMDLQLSRSVVIIRISDLAGRIRVSLQG 570

  Fly   224 CRQLEYRYFVYVEDLS-GYKQIRRWETHFKPRSLGPCTELQCSQLDVFGITSDNSDLKPQVHRGW 287
            ...      |||...| .:...|.....|..:|        ...|.....|:.|..:.|...:
pombe   571 DDA------VYVSGRSPSFAASRPSSVDFMSQS--------TDSLSKNDTTASNGSMTPSSSQ-- 619

  Fly   288 LNHEAILQLKFN-----GEKMFQVHDIETFDPQHVQLKIVPVEKTAGLHVEYSKQEYGKSQLELQ 347
             |:..|:.:..:     ||...:    ...:|..:      .:.:..||.:.:::.      ..|
pombe   620 -NNSVIIDIPRSHFDNAGEVCLE----NLAEPDEI------ADDSIHLHYDAAQEN------SPQ 667

  Fly   348 PTFG--VPYTKGDIVIF------HITLPLERMMEQHFRLECYSMSNELLGSATLVTSDLTGSEG- 403
            |..|  .||.    ::|      ..|:.::.:..:         |:::||......:.|....|
pombe   668 PVNGSSPPYE----LVFVTRNTEEATITIDLLANR---------SHKILGRTVCCLTSLVSDLGN 719

  Fly   404 -------VLHLPIKSAK--------NADETLARL---------------RLPYVAVQPYRYSPLD 438
                   :..||:.|:|        |||..::::               .|...||.....:.|:
pombe   720 HMQSLKPLAPLPLLSSKTLKPIAHVNADVLISKVTVDDRFSSNDGISTPALSLEAVSNVSRTALE 784

  Fly   439 FKNTYAHYWPKSWPNLD----------VGHRGNGKSYIADAPAER------ENTIASFLSAHEHH 487
            ......|   ||.....          :||||.||:     ..:|      |||:.||:.|.:..
pombe   785 DAERSLH---KSATTTSESGKSNGVAVIGHRGLGKN-----QPDRLSLQLGENTLQSFIKAADLG 841

  Fly   488 ADMIELDVHLTADGVPVIYHDFGLRTAPPGKQISRPDQLEYVL---------IKDINYELLKRLR 543
            |..:||||.:|.|.|||:||||.:.......|: ....||..|         |||...::.::.|
pombe   842 ASYVELDVQMTKDMVPVVYHDFIVNETGTDAQV-HSLTLEQFLGASHSPSEEIKDDASDIQQKRR 905

  Fly   544 ------IFSVIAGQVR--EYPSHNA--EPR------MEHRI---FPTLVEVLEKLPKSLGIDVEI 589
                  .|:....||.  |:...||  :|:      :.|.|   |.||.:||:::|:|:|::||.
pombe   906 PRAYSSSFTPSGSQVNFGEFAEENARLKPKVYKGNALGHTICAPFTTLKDVLKEVPQSVGLNVEF 970

  Fly   590 KWPQRRQGGGSEAEQ------TIDKNFFADKVIHQVIQKGCGRPIIFSSFDADMCTMLRFKQNVF 648
            |:|..     ||||:      ..|.||:.|.::..:.:.|..|..|||||:.|:|.:|..| :..
pombe   971 KYPML-----SEAEEEKLLPIAYDYNFYVDTILSIIKKYGGKRKYIFSSFNPDICILLSLK-STN 1029

  Fly   649 PVMFLTQGETKKWQPFLDLRTRTFIAAVNNAQAFELAGTAPHAEDFLG-ENASE-------MLRK 705
            ||:|||:|.|         ..||.:.|.:..||.:.|.    ...||| .:|.|       :::.
pombe  1030 PVLFLTEGGT---------AYRTDVRAASLRQALKFAS----QWSFLGIVSACEPLIMCPRLIKA 1081

  Fly   706 AKDLGQIAVIWGDDCNSKERVQYFTRIGATATCYD 740
            .|.||.....:|...|..:.|:...|.|..|...|
pombe  1082 VKQLGLSCYTYGVLNNDVDNVRRQVRFGVDAVIVD 1116

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18135	NP_788526.1	CBM20_Prei4	166..288	CDD:99888	29/138 (21%)
		GDPD_GDE5	454..741	CDD:176549	102/344 (30%)
gde1	NP_001417947.1	SPX	2..143	CDD:269894
		ANKYR	<354..532	CDD:440430	25/90 (28%)
		ANK repeat	357..382	CDD:293786
		ANK repeat	395..423	CDD:293786
		ANK repeat	425..456	CDD:293786	4/7 (57%)
		ANK repeat	458..490	CDD:293786	11/36 (31%)
		GDPD_YPL110cp_fungi	805..1127	CDD:176548	102/336 (30%)