DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18135 and GDPD4

DIOPT Version :9

Sequence 1:	NP_788526.1	Gene:	CG18135 / 40073	FlyBaseID:	FBgn0036837	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	XP_011543136.1	Gene:	GDPD4 / 220032	HGNCID:	24849	Length:	649	Species:	Homo sapiens

Alignment Length:	373	Identity:	83/373 - (22%)
Similarity:	129/373 - (34%)	Gaps:	128/373 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   360 VIFHITLPLERMMEQHFRLECYSMSNELLGSATLVTSDLTGSEGVLHLPIKSAKNADETLARLR- 423
            |.|::.     .:|:..|:..|.|:                     |...|..|..: .:.|||
Human   149 VAFYVA-----CLEREVRMRRYRMT---------------------HSEKKRLKQCN-VITRLRG 186

  Fly   424 ------LPYVAV------QPYR-YSP-LDFKNTYAHYWPKSWPNLDVGHRGNGKSYIADAP-AER 473
                  ||::.:      .|.. ||| :..|....   ||  |.: .||||        || ...
Human   187 LQVPVGLPFLLILLGLYLMPLGIYSPCIQEKENLG---PK--PTI-FGHRG--------APMLGP 237

  Fly   474 ENTIASFLSAHEHHADMIELDVHLTADGVPVIYHDFGLRTAPPGKQISRPDQLEYVLIKDINYEL 538
            |||:.||..|.||.|..:|.|:||:.|.||.:.|||.|:......::......|....  .|::.
Human   238 ENTMMSFEKAVEHGAHGLETDIHLSYDHVPFLMHDFDLKRTTNIGEVQPESACENPAF--FNWDF 300

  Fly   539 LKRLRIFSVIAG------QVREYPSHNAEP-------RMEHRIFPTLVEVL---EKLPKSLGIDV 587
            |..|.     ||      ::|  |.:|.:|       |..::..|||.::|   ||..|.:..|:
Human   301 LSTLN-----AGKWFVKPELR--PFYNMKPLSEADKERARNQSIPTLADLLTLAEKERKFVIFDL 358

  Fly   588 EIKWPQRRQGGGSEAEQTIDKNFFADKVIHQVIQKGCGRPIIFSSFDADMCTMLRFKQNVFPVMF 652
            ....|:...           ::.|..:|:..::.....:.:||
Human   359 HRPPPKHPL-----------RHTFVRQVVSVILASKIEQHLIF---------------------- 390

  Fly   653 LTQGETKKWQPFLDLRTRTFIAAVNNAQAFELAGTAPHAEDFLGENAS 700
                    |.|..|   |.::.:|  |..|:..|.....|.....|.|
Human   391 --------WLPAHD---RQYVRSV--APGFQHVGRLVSIETLAKNNIS 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18135	NP_788526.1	CBM20_Prei4	166..288	CDD:99888
		GDPD_GDE5	454..741	CDD:176549	61/264 (23%)
		GDPD	458..744	CDD:281062	60/260 (23%)
GDPD4	XP_011543136.1	PI-PLCc_GDPD_SF	205..517	CDD:301322	69/290 (24%)
GDPD4	XP_011543136.1	UgpQ	223..482	CDD:223657	63/269 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0584
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900