Protein Alignment SIGLEC16 and Siglece

DIOPT Version :9

• Sequence 1: NP_001335293.2
• Gene: SIGLEC16 / 400709
• HGNCID: 24851
• Length: 481
• Species: Homo sapiens
• Sequence 2: XP_006541381.1
• Gene: Siglece / 83382
• MGIID: 1932475
• Length: 520
• Species: Mus musculus
• Alignment Length: 541
• Identity: 172/541 - (31%)
• Similarity: 237/541 - (43%)
• Gaps: 159/541 - (29%)

Human     1 MLLLPLLLPVLGAGSLNKDPSYSLQVQRQVPVPEGLCVIVSCNLSYPR---DGWDESTAAYGYWF 62
            :|||.||..:.|....|....::|.|:|:|.|.|||||:|.||.||.:   ..|.:|...:|:|:
Mouse     4 LLLLLLLWGIKGVEGQNPQEVFTLNVERKVVVQEGLCVLVPCNFSYLKKRLTDWTDSDPVHGFWY 68

Human    63 KGWTSPKTGAPVATNNQSREVEMSTRDRFQLTGDPGKGSCSLVIRDAQREDEAWYFFRVERGSRV 127
            :..|..:..:.|||||..|:....||:||.|.|||.:..|||.||:.:::|...||||:||| :.
Mouse    69 REGTDRRKDSIVATNNPIRKAVKETRNRFFLLGDPWRNDCSLNIREIRKKDAGLYFFRLERG-KT 132

Human   128 RHSFVNNLFFLKVTALTQKPDVYIPETLEPGQPVTVICVFNWAFKKCPAPSFSWTGAALSPRRTR 192
            :::::.:...|.|||||..|.:.:|||||.|.|..:.|...|.......|.|||||.::|...|
Mouse   133 KYNYMWDKMTLVVTALTNTPQILLPETLEAGHPSNLTCSVPWDCGWTAPPIFSWTGTSVSFLST- 196

Human   193 PSTSHFSVLSFTPSPQDHDTDLTCHVDFSRKGVSAQRTVRLRVASLELQGNVIYLEVQKGQFLRL 257
             :|:..|||:.||.||||.|:|||.|......||.:.|:|
Mouse   197 -NTTGSSVLTITPQPQDHGTNLTCQVTLPGTNVSTRMTIR------------------------- 235

Human   258 LCAADSQPPATLSWVLQDRVLSSSHPWGPRTLGLELRGVRAGDSGRYTCRAENRLGSQQRALDLS 322
                                                                           |:
Mouse   236 ---------------------------------------------------------------LN 237

Human   323 VQYPPENLRVMVSQANRTVLENLRNGTSLRVLEGQSLRLVCVTHSSPPARLSWTRWGQTVGPSQP 387
            |.|.|:||.|.:.|...:|...|:||:||.:.|||||||:|.|.|.|||.|||:....|:.||:.
Mouse   238 VSYAPKNLTVTIYQGADSVSTILKNGSSLPISEGQSLRLICSTDSYPPANLSWSWDNLTLCPSKL 302

Human   388 SDPGVLELPRVQMEHEGEFTCHARHPLGSQRVSLSFSVHCKSGPMTGVVL------VAVGEVAMK 446
            |.||:|||..|.::|.|.:||.|:|.||||.:|||.|      |.:...|      ..||.....
Mouse   303 SKPGLLELFPVHLKHGGVYTCQAQHALGSQHISLSLS------PQSSATLSEMMMGTFVGSGVTA 361

Human   447 ILLLCLCLILL-----------------------------------------------------R 458
            :|.|.:|::||                                                     |
Mouse   362 LLFLSVCILLLAWWELLSNTGASVTGALATLTTCHRLNCKQRVGESANRTPSCYTERLLGVLTPR 426

Human   459 VRSCRRKAARAALGMEAADAV 479
            |||.|||.||.|:.....||:
Mouse   427 VRSYRRKPARPAVVAPHPDAL 447

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIGLEC16	NP_001335293.2	Ig_Siglec_N	22..141	CDD:143189	48/121 (40%)
		IG_like	247..323	CDD:214653	1/75 (1%)
		IG_like	350..425	CDD:214653	41/74 (55%)
Siglece	XP_006541381.1	Ig	25..146	CDD:386229	48/121 (40%)
		Ig	152..225	CDD:386229	33/74 (45%)
		Ig_3	264..326	CDD:372822	32/61 (52%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
HGNC	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG38224
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001383
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X34
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920