DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SIGLEC16 and igcm-4

DIOPT Version :9

Sequence 1:	NP_001335293.2	Gene:	SIGLEC16 / 400709	HGNCID:	24851	Length:	481	Species:	Homo sapiens
Sequence 2:	NP_508377.1	Gene:	igcm-4 / 180518	WormBaseID:	WBGene00022418	Length:	541	Species:	Caenorhabditis elegans

Alignment Length:	224	Identity:	52/224 - (23%)
Similarity:	89/224 - (39%)	Gaps:	33/224 - (14%)

- Green bases have known domain annotations that are detailed below.

Human   222 RKGVSAQRTVRLRVASLELQGNVIYLEVQKGQFLRLLC--AADSQPPATLSWVLQDRVL--SSSH 282
            |..|.|.|.:..|:.::|.:   ..:.:.:.|| ||:|  .|..:....:.|......|  .|.:
Worm    23 RPHVEAARGMPPRMRNVETK---FRIPLGQKQF-RLVCPIIATEKDSTMIQWSKNGEQLDWDSQY 83

Human   283 PWGPRTLGLELRGVRAGDSGRYTCRAENRLGSQQRALDLSV----QYPPENLRVMVSQANRTVLE 343
            .....:..|:::.|:..|||||.|:|.|..|  .:.::..|    |:..||     |..:..||.
Worm    84 KLSKDSKELKMKSVKFEDSGRYQCQATNGFG--HKTIEFIVHVHDQHDKEN-----SVKDYLVLS 141

Human   344 NLRNGTS------------LRVLEGQSLRLVCVTHSSPPARLSWTRWGQTVGPSQPSDPGVLELP 396
            |.....|            :::..|..|.|.|....:|...:.|.:....:..........:.:.
Worm   142 NTTASPSWLIDMNSEWRSPIKINTGGKLELRCPAQGNPLPEIRWYQNEMEISEKTHKHVSTITVE 206

Human   397 RVQMEHEGEFTCHARHPLGSQRVSLSFSV 425
            .|:..|.|.:.|...:||||  :|.:|.|
Worm   207 PVESSHSGVYRCVVENPLGS--LSFAFDV 233

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SIGLEC16	NP_001335293.2	Ig_Siglec_N	22..141	CDD:143189
		IG_like	247..323	CDD:214653	20/79 (25%)
		IG_like	350..425	CDD:214653	17/86 (20%)
igcm-4	NP_508377.1	IGc2	52..114	CDD:197706	18/62 (29%)
		I-set	159..235	CDD:254352	17/77 (22%)
		IGc2	166..225	CDD:197706	11/58 (19%)
		IG_like	261..373	CDD:214653
		Ig	269..374	CDD:299845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910