Protein Alignment SIGLEC16 and igcm-1

DIOPT Version :9

• Sequence 1: NP_001335293.2
• Gene: SIGLEC16 / 400709
• HGNCID: 24851
• Length: 481
• Species: Homo sapiens
• Sequence 2: NP_508166.1
• Gene: igcm-1 / 180433
• WormBaseID: WBGene00018215
• Length: 1073
• Species: Caenorhabditis elegans
• Alignment Length: 562
• Identity: 110/562 - (19%)
• Similarity: 190/562 - (33%)
• Gaps: 208/562 - (37%)

Human    18 KDPS---YSLQVQRQVPVPEGLCVIVSCNLS---YPRDGWDESTAAYGYWFKGWTSPKTGAPVAT 76
            |:||   |.||...     ||  :::.|.:.   :.|..::.:.|.|                 .
 Worm    29 KEPSSEPYFLQEGN-----EG--IVIPCVVKPEYFDRQKYEINWARY-----------------N 69

Human    77 NNQSREVEMSTR------DRFQLTGDPGKGSCSLVIRDAQRED-EAWYFFRV--ERGSRVRHSFV 132
            |.|.|.:..:.:      .||.|..|...|:.||.|.:.::.. |..|...|  ...|.|::|.:
 Worm    70 NGQLRMITKNDKLLAKKHSRFILENDSATGNYSLRITEVEKNSVEGTYHCNVIGTDDSDVQYSAL 134

Human   133 NNLFFLKVTALTQKPDVYI----PETLEPGQPVTVICVFNWAFKKCPAPSFSWTGAALSPRRTRP 193
                 ..|..|....|..|    .|::..|..:|..||   :....|.|:|:||    .|..|..
 Worm   135 -----ATVVVLVPPGDPIISTTPSESVIEGDFMTAKCV---SVGGSPQPTFTWT----LPNDTIA 187

Human   194 STSHF----------SVLSFTPSPQDHDTDLTCHVDFSRKGVSAQRTVRLRVASLEL-------- 240
            |::.|          |:|.|..:..|....:.|  |.:.:.:....|.:::.:.|.:
 Worm   188 SSAIFTTQFRDGATESLLHFRVTSSDDGKSVQC--DVTNRAMLGGETKQVKSSQLNVLYKPVVFV 250

Human   241 --QGNVIYLEVQKGQFLRLLCAADSQPPATLSWVLQDRVLSSSHPWGPRTLGLELRG------VR 297
              ..|:.:|.|::|:.:.|.|.:.|.|||            .|:.|.....|...:|      |.
 Worm   251 TPTENLTHLSVEEGELVNLTCNSASNPPA------------HSYEWKHIASGERYQGKIWPIRVD 303

Human   298 AGDSGRYTCRAENRLGSQQRALDLSVQYPP-------------ENLRVM---------------- 333
            :..||.:.||:.|.||.....|.:.||:.|             |::.::
 Worm   304 SSMSGDFECRSTNELGEGTAVLKMVVQHIPRINVPESISPNEMEDIDILCEVSAVPEVIDIKWVG 368

Human   334 ---------------VSQA---NRTVL------------ENLRNGTSLRVLE------------- 355
                           :|:|   |.|.:            ...|.||...:::
 Worm   369 PNGFKQNGSRLTITSISKAQSGNYTCMATNFLTVYGHSGSQQRMGTGTTIVDVKRKPGQAQIVSA 433

Human   356 ------GQSLRLVCVTH--SSPPARLSWTRWGQTVGPSQPSDPGV----------LELPRVQMEH 402
                  |::::|:|...  .:|.|..:|         :.||..|:          .|:...|:..
 Worm   434 RQNVDVGETIKLMCQAEDAGNPSASYTW---------ASPSSGGIFGLEGHTEKSFEVRNAQLSD 489

Human   403 EGEFTCHARHPLGSQRVSLSFSVHCKSGPMTGVVLVAVGEVA 444
            .|.::|.|.:.||..::              |.|::.|.|.|
 Worm   490 NGVYSCKAYNDLGEGKI--------------GTVMITVIEKA 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIGLEC16	NP_001335293.2	Ig_Siglec_N	22..141	CDD:143189	26/130 (20%)
		IG_like	247..323	CDD:214653	22/81 (27%)
		IG_like	350..425	CDD:214653	16/105 (15%)
igcm-1	NP_508166.1	Ig	45..119	CDD:299845	17/90 (19%)
		Ig	146..226	CDD:299845	21/88 (24%)
		Ig_3	245..316	CDD:290638	19/82 (23%)
		IG_like	258..329	CDD:214653	22/82 (27%)
		IG_like	338..398	CDD:214653	5/59 (8%)
		IGc2	347..398	CDD:197706	5/50 (10%)
		Ig_2	429..513	CDD:290606	18/106 (17%)
		IG_like	437..513	CDD:214653	18/98 (18%)
		Ig	537..615	CDD:143165
		IG_like	644..728	CDD:214653
		IGc2	646..719	CDD:197706
		FN3	733..843	CDD:238020

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910