DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SIGLEC16 and LOC101884840

DIOPT Version :9

Sequence 1:	NP_001335293.2	Gene:	SIGLEC16 / 400709	HGNCID:	24851	Length:	481	Species:	Homo sapiens
Sequence 2:	XP_021322151.1	Gene:	LOC101884840 / 101884840	-ID:	-	Length:	692	Species:	Danio rerio

Alignment Length:	352	Identity:	76/352 - (21%)
Similarity:	140/352 - (39%)	Gaps:	84/352 - (23%)

- Green bases have known domain annotations that are detailed below.

Human    37 CVIVSCNLSYP-------RDGWDESTAAYGYWFKGWTSPKTGAPVATNNQSREVEMSTRDRFQLT 94
            ||::.|:.|..       |..|..:...|.|    .|.|.            :|..:.:.|.:|.
Zfish   342 CVVIPCSFSVEHKYLTGLRVRWVNNNGGYMY----HTDPV------------DVLDNFKGRTRLL 390

Human    95 GDPGKGSCSLVIRDAQREDEAWYFFRVERGSRVRHSFVNNLFFLKVTALTQKPDV-YIPETLEPG 158
            |:|.:.:|:|.:.|.:..|...:.|:.|: ...::||.|:..|:.:.|...:|.: .:||.:|||
Zfish   391 GNPDERNCTLEMDDVRTHDNGPFCFQAEK-KEEKYSFNNSCVFIIMRASPDQPVMSSVPEDIEPG 454

Human   159 QPVTVICVFNWAFKKCPAPSFSWTGAALSPRRTRPSTSH----------FSVLSFTPSPQDHDTD 213
            ..|||.|.........| |..:|     |....|.:.||          .|.:.|.|:..:.:.:
Zfish   455 TAVTVKCSVKHTCSSHP-PKITW-----SVPTVRETISHNPMGGGVWETVSKMKFIPTGYEEEDE 513

Human   214 LTCHVDF----SRKGVSAQRTVRLRVASLE-----LQGNVIYLEVQKGQFLRLLCAADSQPPATL 269
            :.|..:|    ::...||..:|: |:.::|     :..:::::         |:|
Zfish   514 IICSANFWGGKTQSNSSAPLSVK-RIQAVESGPYIIASSLVFV---------LIC---------- 558

Human   270 SWVLQDRVLSSSH---PWGPRTLGLELRGVRAGDSGRYTCRAENRL-----GSQQRALDLSVQYP 326
              :|....:...|   |....|...:.|.|....|.|:: ..|.|.     |::....|...:.|
Zfish   559 --ILAGVFMYKRHQRQPCEDITRSEQRRSVWNRFSSRFS-MPEGRAAWFNSGNRSDIRDAPGRPP 620

Human   327 -PENLRVMVSQANRTVLENLRNGTSLR 352
             ||..|.:.|:.:|.  ::.||..::|
Zfish   621 KPEQRRSIWSRFSRH--QSPRNNANMR 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SIGLEC16	NP_001335293.2	Ig_Siglec_N	22..141	CDD:143189	25/110 (23%)
		IG_like	247..323	CDD:214653	14/83 (17%)
		IG_like	350..425	CDD:214653	1/3 (33%)
LOC101884840	XP_021322151.1	Ig	1..>83	CDD:325142
		Ig	226..307	CDD:325142
		Ig	335..426	CDD:325142	21/100 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12035
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X34
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.010