DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6836 and TMEM184A

DIOPT Version :9

Sequence 1:	NP_649079.2	Gene:	CG6836 / 40070	FlyBaseID:	FBgn0036834	Length:	328	Species:	Drosophila melanogaster
Sequence 2:	NP_001091089.1	Gene:	TMEM184A / 202915	HGNCID:	28797	Length:	413	Species:	Homo sapiens

Alignment Length:	315	Identity:	61/315 - (19%)
Similarity:	119/315 - (37%)	Gaps:	90/315 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 IFIASLLTI----LNISIFATTVSRLRRHLDKPLLGPSIMMVGLYPIISVAALVTILVPYSWFI- 110
            ||:.:.|.:    :.:.:.:.||.:.:|::.:.||     :|.:|...|..:|: :|..:.:::
Human    61 IFVWTALVLTCHQIYLHLRSYTVPQEQRYIIRLLL-----IVPIYAFDSWLSLL-LLGDHQYYVY 119

  Fly   111 ------CHTVMHVMFMVGGPVFRTLLFRYVGSEQNYVKETAGEAVQLNTPPCCCC---------- 159
                  |:..    |::..  |.:|.|:|:|.|...:.|..|:.::.:.....||
Human   120 FDSVRDCYEA----FVIYS--FLSLCFQYLGGEGAIMAEIRGKPIKSSCLYGTCCLRGMTYSIGF 178

  Fly   160 -----------CLCLP-MVIPTKAKLCISRYMVWQMPFWQGSIMLVMNILYYRDIQ--LYRQVMF 210
                       ||..| |.:.|.......:|.........|  .|.:.::|...:.  ||...:|
Human   179 LRFCKQATLQFCLVKPVMAVTTIILQAFGKYHDGDFNVRSG--YLYVTLIYNASVSLALYALFLF 241

  Fly   211 FFIPFIVCSIVLGAWSLQITVRMITKVRGDYQLRKKMFCLQLVVMLCKLQYLVL----------- 264
            :|                 |.|.:.:   .:|...|...::.|:.|...|.|:|
Human   242 YF-----------------TTRELLR---PFQPVLKFLTIKAVIFLSFWQGLLLAILERCGVIPE 286

  Fly   265 YDQLDGIKMG-GEYPINHTVYKQTIINILILVEMVLVSMMVQSAYRTPVQVQIDE 318
            .:...|.|:| |.....:.       |.:|.|||:..|:.::.|:  |.||..::
Human   287 VETSGGNKLGAGTLAAGYQ-------NFIICVEMLFASVALRYAF--PCQVYAEK 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6836	NP_649079.2	Solute_trans_a	50..309	CDD:281602	58/304 (19%)
TMEM184A	NP_001091089.1	Solute_trans_a	55..325	CDD:281602	58/306 (19%)
TMEM184A	NP_001091089.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	372..413
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900