DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PRICKLE3 and esn

DIOPT Version :9

Sequence 1:	NP_006141.2	Gene:	PRICKLE3 / 4007	HGNCID:	6645	Length:	615	Species:	Homo sapiens
Sequence 2:	NP_001260760.1	Gene:	esn / 53557	FlyBaseID:	FBgn0263934	Length:	1134	Species:	Drosophila melanogaster

Alignment Length:	684	Identity:	271/684 - (39%)
Similarity:	338/684 - (49%)	Gaps:	177/684 - (25%)

- Green bases have known domain annotations that are detailed below.

Human    75 DFQRHSISDDDSGCASEEYAWVPPGLKPEQVYQFFSCLPEDKVPYVNSPGEKYRIKQLLHQLPPH 139
            ||||:|.||||||||.|||.||||||:|:||..:||.||:||||||||||||||:|||||||||.
  Fly   485 DFQRNSQSDDDSGCALEEYTWVPPGLRPDQVRLYFSQLPDDKVPYVNSPGEKYRVKQLLHQLPPQ 549

Human   140 DSEAQYCTALEEEEKKELRAFSQQRKRENLGRGIVRIF----PVTITGAICEECGKQIGGGDIAV 200
            |:|.:||.:|.:||:||||.||.|||||.||||.||:.    |       |:.|.:.:.||||.|
  Fly   550 DNEVRYCHSLSDEERKELRIFSAQRKREALGRGAVRLLSDERP-------CKGCEEPLSGGDIVV 607

Human   201 FASRAGLGACWHPQCFVCTTCQELLVDLIYFYHVGKVYCGRHHAECLRPRCQACDEIIFSPECTE 265
            ||.|.|...||||.||||:.|:|||||||||...|.:||||||||..:|||.||||||||.||||
  Fly   608 FAQRLGAQLCWHPGCFVCSVCKELLVDLIYFQRDGNLYCGRHHAETQKPRCSACDEIIFSDECTE 672

Human   266 AEGRHWHMDHFCCFECEASLGGQRYVMRQSRPHCCACYEARHAEYCDGCGEHIGLDQGQMAYEGQ 330
            ||||.|||.||.|.|||..||||||:||:.:|:|.||::...|||||.|||.||:|||||:::||
  Fly   673 AEGRTWHMKHFACQECEHQLGGQRYIMREGKPYCLACFDTMFAEYCDYCGEVIGVDQGQMSHDGQ 737

Human   331 HWHASDRCFCCSRCGRALLGRPFLPRRGLIFCSRACSLGSEPTAPGPSRRSWSAGPVTAPLAAST 395
            ||||:|:||.|..|..:|||||||||||.|:||.|||.|..||   ||  ..|:||...|
  Fly   738 HWHATDQCFSCCTCRCSLLGRPFLPRRGTIYCSIACSKGEPPT---PS--DTSSGPQLRP----- 792

Human   396 ASFSAVKGASETTTKGTSTELA--PATGPEEPSRFLRGAPHRH-----SMPEL------------ 441
                       |....||:::|  |..|.|......|.|.|.|     |..:|
  Fly   793 -----------THRASTSSQIAKSPRRGGERERDPGRKAHHGHPKATGSAGDLLERQERQRMEAA 846

Human   442 ---------GLRSVP---EPPP----------------------ESPGQPNLRPD------DSAF 466
                     |:..:|   .|||                      ::....|..||      |.:.
  Fly   847 GVADLLLGGGVPGMPRPAHPPPIDLTELGISLDNICAGDKSIFGDTQTLTNSMPDMLLSKADDSH 911

Human   467 GRQSTPRVSFRDP---------------LVSEGGPRRTL--------------SAPPAQR----- 497
            ..||..:::...|               |..:..|.|.|              ...||::
  Fly   912 SYQSIDKINLNSPSNSDLTQSTQELANELELDNEPVRELPHDGYEQLFANNRNQEHPAEQYDDEQ 976

Human   498 ------------------RRPRSPPPRAPSRRRHHHHNHHHHH-----NRHPSRRRHYQCDAGS- 538
                              .|.:|....:.:|||....|.....     |:...|..:.|...|:
  Fly   977 LDNRPMKEVRFHSVQDTMSRSKSYTDNSNARRRRRRRNQSRSSSEMQINQTNLRLHNAQTQVGTT 1041

Human   539 ---------GSDSESCSSSPSSSSSESSEDDGFFL-------GERIPLPPHLC-----RPMPAQD 582
                     ..|..|..|:.|||||...:|..:.|       |.|:...|:..     :...|||
  Fly  1042 PLNLLNNLDNCDVASICSTCSSSSSSDMDDYVYRLPARKHYGGVRVAYVPNDALAYERKKKMAQD 1106

Human   583 TAMETFNSPSLSLPRDSRAGMPR-QARDKNCIVA 615
            :::    :|...  ..|..|.|. ....|||.::
  Fly  1107 SSL----APGAG--NASVGGAPAIMHESKNCTIS 1134

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PRICKLE3	NP_006141.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		PET_Prickle	82..178	CDD:193602	71/99 (72%)
		LIM1_Prickle	186..244	CDD:188799	35/57 (61%)
		LIM2_Prickle	249..304	CDD:188802	40/54 (74%)
		LIM3_Prickle	309..367	CDD:188804	40/57 (70%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	396..567		52/303 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	587..615		7/28 (25%)
esn	NP_001260760.1	PET_Prickle	492..588	CDD:193602	71/95 (75%)
		LIM1_Prickle	593..651	CDD:188799	35/57 (61%)
		LIM2_Prickle	656..711	CDD:188802	40/54 (74%)
		LIM3_Prickle	716..774	CDD:188804	40/57 (70%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152355
Domainoid	1	1.000	149	1.000	Domainoid score	I4411
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	511	1.000	Inparanoid score	I1323
Isobase	1	0.950	-	0	Normalized mean entropy	S3648
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D422310at33208
OrthoFinder	1	1.000	-	-		FOG0001066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24211
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.850