Protein Alignment PRICKLE3 and Tes

DIOPT Version :9

• Sequence 1: NP_006141.2
• Gene: PRICKLE3 / 4007
• HGNCID: 6645
• Length: 615
• Species: Homo sapiens
• Sequence 2: NP_611215.1
• Gene: Tes / 36965
• FlyBaseID: FBgn0034223
• Length: 816
• Species: Drosophila melanogaster
• Alignment Length: 812
• Identity: 147/812 - (18%)
• Similarity: 207/812 - (25%)
• Gaps: 476/812 - (58%)

Human     6 SRRRRSGRAPPEAEDPDRGQPCNSCREQCPGFLLHGWRKICQHCKCPREEHAVHAVPVDLERIMC 70
            |||.:..|: ....:...|.||..|:::|||..||.|||:|::||||:.:   |..|.|
  Fly    24 SRREQLKRS-KLGHEAGAGAPCAECKDKCPGLDLHFWRKVCRNCKCPKIQ---HVCPDD------ 78

Human    71 RLISDFQRHSISDDDSGCASEE-----------------------YAWVPPGLKPEQVYQFFSCL 112
                        ||.:|.|..|                       ..||||...|:.|..:...|
  Fly    79 ------------DDATGWAQFEILGQIRAKPAYIKIKALASQPVQLEWVPPNAAPDVVTDYMEKL 131

Human   113 PEDKVPYVNSPGEKYRIKQLLHQLPPHDSEAQYCTALEEEEKKELRAFSQQRKRENLGRGIV--- 174
            ...::|...|.....|..||..|:||||.:|..|..|.|.|..:|:.:.|:.:.:.:|:|:|
  Fly   132 GTAQIPVAGSDAALKRKMQLELQVPPHDLDAALCDGLTETEAIQLQQYVQKLREQCVGQGVVVRL 196

Human   175 ----------------------------------------------------------------- 174
                                                                             
  Fly   197 GDRLNHAQVEHVAPALMPTQEAQQTWQSLGLMPVADDTLNELLANPKVAQALASPASAHPKLLVA 261

Human   175 ----------------------------------------------------------------- 174
                                                                             
  Fly   262 FSEPLCESTAQFEENGALRAQTREKLLGISKPALLSLVTHGIVYDKVLGILQEKKLNISRDPKLG 326

Human   175 ----------------------------------------------------------------- 174
                                                                             
  Fly   327 PIAEFRKEYVNNPQFRAEINTICPQPPMTPIKSPPGTPFNSPLPLKNPVQIRMGAQMRQDTPMRR 391

Human   175 ----------------------------------------------------------------- 174
                                                                             
  Fly   392 VKFGGVSTIVYDCGLPANTDYDRDPVFAQILQAEPLKHAFQEARAGRAPSSVVISNIPAPVASLA 456

Human   175 ----------------------------------RIF---------------------------- 177
                                              |:|
  Fly   457 ELRGLNPATRAQLQSVGLDKNMLQSAVSNAPYYDRLFRSLHDKGISHDQCHLLQPMKQVHDWLLD 521

Human   178 ---------------------------------------------PVT----------------- 180
                                                         |.|
  Fly   522 DDQLLDEIDKVFADMANGCKDISYPKPSLGELPTSQSSDSGFHSKPPTPGYGSEDLTAGQGRFAS 586

Human   181 ITG-----------------------------------AICEECGKQIGGGDIAVFASRAGLGAC 210
            |.|                                   .:|.:|.:.|..|::||.|.|||....
  Fly   587 IPGIEDMNMYPSCAGMPEQFQQLRLHGDEASGKNSTRTILCADCNQPIAMGEVAVKADRAGKEIA 651

Human   211 WHPQCFVCTTCQELLVDLIYFYHVGKVYCGRHHAECLR-PRCQACDEIIFSPECTEAEGRHWHMD 274
            |||.||.|.||:|||.||:||:|.|:|:|||..|..|: |||:||||:||:.|.|.||...:|:.
  Fly   652 WHPGCFKCITCRELLADLVYFFHQGQVFCGRDLAIRLKIPRCRACDELIFTKEYTAAEEATFHIK 716

Human   275 HFCCFECEASLGGQRYVM--RQSRPHCCACYEARHAEYCDGCGEHIG-LDQGQMAYEGQHWHASD 336
            ||||::|:..|.||:|:.  :.:.|.|..||:...|..|..|...|| .||| :|:...|||||
  Fly   717 HFCCYQCDEPLAGQQYIADEKSNMPLCLLCYDRLFAVRCQRCKVAIGPADQG-VAWGDVHWHAS- 779

Human   337 RCFCCS--RCGRALLGRPFLPRRGLIFCSRAC 366
             ||.|:  :|.:.|:|..|..:..:.|||..|
  Fly   780 -CFVCAGVQCSKPLIGGRFCVKENMPFCSPTC 810

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRICKLE3	NP_006141.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26		5/19 (26%)
		PET_Prickle	82..178	CDD:193602	34/488 (7%)
		LIM1_Prickle	186..244	CDD:188799	31/57 (54%)
		LIM2_Prickle	249..304	CDD:188802	26/56 (46%)
		LIM3_Prickle	309..367	CDD:188804	24/61 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	396..567
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	587..615
Tes	NP_611215.1	PET_testin	110..197	CDD:193604	27/86 (31%)
		LIM1_Testin_like	627..684	CDD:188726	31/56 (55%)
		LIM2_Testin_like	691..748	CDD:188727	26/56 (46%)
		LIM	755..810	CDD:295319	23/57 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I11790
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D422310at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820