Protein Alignment CG18223 and GZMH

DIOPT Version :9

• Sequence 1: NP_649077.1
• Gene: CG18223 / 40068
• FlyBaseID: FBgn0036832
• Length: 322
• Species: Drosophila melanogaster
• Sequence 2: NP_219491.1
• Gene: GZMH / 2999
• HGNCID: 4710
• Length: 246
• Species: Homo sapiens
• Alignment Length: 287
• Identity: 76/287 - (26%)
• Similarity: 122/287 - (42%)
• Gaps: 67/287 - (23%)

  Fly    18 FLLLLLPILDAG----DPIGSHFVRRRAKRLSSPY-----FDKEKTLVLAKYVVSIRSRRPHKLF 73
            |||||..:|..|    :.||.|    .||..|.||     |.:||:          |.|
Human     4 FLLLLAFLLTPGAGTEEIIGGH----EAKPHSRPYMAFVQFLQEKS----------RKR------ 48

  Fly    74 GDNHFCGGVIISRTYILTSAHCAMDKRKIVHRSRVLVVVAGTTNRLKSRKGLSLNMEVKK----- 133
                 |||:::.:.::||:|||         :...:.|..|..| :|.::.....:.||:
Human    49 -----CGGILVRKDFVLTAAHC---------QGSSINVTLGAHN-IKEQERTQQFIPVKRPIPHP 98

  Fly   134 IFVPDKFTVFNTNNIALMMLAKKLPLDNPLVGVINLPT--ADPEPGLNYTVLGWGRIFKGGPLAS 196
            .:.|..|    :|:|.|:.|.:|... ...|..:.||:  |..:||...:|.|||.: ....||:
Human    99 AYNPKNF----SNDIMLLQLERKAKW-TTAVRPLRLPSSKAQVKPGQLCSVAGWGYV-SMSTLAT 157

  Fly   197 DILHIDVELLPRDICEKKVH--IFKEEMMCAGNLNNTMDENPCAGDTGSPLIFNETVFGVVSYRV 259
            .:..:.:.:.....||:..|  ..:...:|.|:...|  :....||:|.||:..:...|::||
Human   158 TLQEVLLTVQKDCQCERLFHGNYSRATEICVGDPKKT--QTGFKGDSGGPLVCKDVAQGILSY-- 218

  Fly   260 GCGSK--TLPSIYTNVYMHMDWINGIM 284
              |:|  |.|.:|..|...:.||...|
Human   219 --GNKKGTPPGVYIKVSHFLPWIKRTM 243

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18223	NP_649077.1	Tryp_SPc	60..283	CDD:238113	57/233 (24%)
		Tryp_SPc	60..280	CDD:214473	55/230 (24%)
GZMH	NP_219491.1	Tryp_SPc	21..242	CDD:238113	68/267 (25%)
		Mediates the preference for acidic residues at the P3' and P4' sites	46..48		1/1 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910