DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18223 and PRSS55

DIOPT Version :9

Sequence 1:	NP_649077.1	Gene:	CG18223 / 40068	FlyBaseID:	FBgn0036832	Length:	322	Species:	Drosophila melanogaster
Sequence 2:	NP_940866.2	Gene:	PRSS55 / 203074	HGNCID:	30824	Length:	352	Species:	Homo sapiens

Alignment Length:	321	Identity:	89/321 - (27%)
Similarity:	138/321 - (42%)	Gaps:	74/321 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 IFSFLLFLLLL--------LPILDAGDPI-----GSHFV--------------------RRRAKR 43
            :||.||.|.|:        .|:.:||..|     |:|..                    |.|..|
Human     3 LFSVLLLLSLVTGTQLGPRTPLPEAGVAILGRARGAHRPQPPHPPSPVSECGDRSIFEGRTRYSR 67

  Fly    44 LSSPYFDKEKTLVLAKYVVSIRSRRPHKLFGDNHFCGGVIISRTYILTSAHCAMDKRKIVHRSRV 108
            ::.   ..|..:....:.|||::|       ...||||.|:::.:|||:|||...:......
Human    68 ITG---GMEAEVGEFPWQVSIQAR-------SEPFCGGSILNKWWILTAAHCLYSEELFPEE--- 119

  Fly   109 LVVVAGTTNRLKSRKGLSLNMEVKK---IFVPDKFTVFN-TNNIALMMLAKKLPLDNPLVGVINL 169
            |.||.| ||.|.|.     :||:|:   |.:...|...| .|:|||::||..:.||:..|.:. |
Human   120 LSVVLG-TNDLTSP-----SMEIKEVASIILHKDFKRANMDNDIALLLLASPIKLDDLKVPIC-L 177

  Fly   170 PTADPEPG----LNYTVLGWGRIFKG--GPLASDILHIDVELLPRDICEKKVHIFKEEMMCAGNL 228
            ||   :||    ....|.|||:....  ..:.:|::...:.::..:.|.|......:.|:|||..
Human   178 PT---QPGPATWRECWVAGWGQTNAADKNSVKTDLMKAPMVIMDWEECSKMFPKLTKNMLCAGYK 239

  Fly   229 NNTMDENPCAGDTGSPLIFNET------VFGVVSYRVGCGSKTLPSIYTNVYMHMDWINGI 283
            |.:.|  .|.||:|.||:....      ..|::|:...||.|..|.|||::..:..||..:
Human   240 NESYD--ACKGDSGGPLVCTPEPGEKWYQVGIISWGKSCGEKNTPGIYTSLVNYNLWIEKV 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18223	NP_649077.1	Tryp_SPc	60..283	CDD:238113	73/238 (31%)
CG18223	NP_649077.1	Tryp_SPc	60..280	CDD:214473	71/235 (30%)
PRSS55	NP_940866.2	Tryp_SPc	67..295	CDD:214473	73/252 (29%)
		Tryp_SPc	68..298	CDD:238113	74/254 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	308..330
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910