DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir75d and Ir75b

DIOPT Version :9

Sequence 1:	NP_649074.2	Gene:	Ir75d / 40065	FlyBaseID:	FBgn0036829	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	NP_001137966.2	Gene:	Ir75b / 8673994	FlyBaseID:	FBgn0261402	Length:	605	Species:	Drosophila melanogaster

Alignment Length:	566	Identity:	135/566 - (23%)
Similarity:	221/566 - (39%)	Gaps:	115/566 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 KMGILLLEFSSECALNLLRWSAASEHNYFTTNRFWLLLTEDPGDIDLLE----DPEIFIPPDSEL 199
            |:|:.|   ...|..:......||...:|:....||:..... :..:||    :.:||:..|...
  Fly    64 KLGVFL---DINCDKSGTVLDMASAKRFFSHRYHWLIYDRSM-NFSVLESHFKEAQIFVDADVTY 124

  Fly   200 RVLHYENVGNFSCSLIDLYKVAAWKPLKRTLVGH--------------NIRNSRHVIHALQHFGS 250
             |.|.....||  .|.|:|...      |.|.|.              |.|..|::...  :..|
  Fly   125 -VTHDPFSKNF--LLYDVYNKG------RQLGGELNITADREIFCNKTNCRVERYLSEL--YTRS 178

  Fly   251 AITYRQDLEGIVFN-SAIVIAFPDLFTNIEDLSLRHIDTISKVNHRLMLELANRLNMSYNTYQTV 314
            |:.:|:...|:... :|:|.|.|      .::|::.|.......:|:.|:          ||..:
  Fly   179 ALQHRKSFTGLTMRATAVVTALP------LNVSIKEIFDFMNSKYRIQLD----------TYARL 227

  Fly   315 NYGWRQP-------------------NGSFDGLMGRFQRYELDLAQLAIFMRLDRIALVDFVAET 360
            .|..|||                   ..:..|::|.....:.|||........||...:..:.:.
  Fly   228 GYQARQPLRDMLDCKFKYIFRDRWSDGNATGGMIGDLILDKADLAIAPFIYSFDRALFLQPITKF 292

  Fly   361 YRVRAGIMFRQP-PLSA--VANIFAMPFENDVWVSILMLLII------TTVVLVLELFFSPHNHD 416
            ...|...|||.| .:||  .|..|..||...||::..:||::      .|.:|.....:.|
  Fly   293 SVFREICMFRNPRSVSAGLSATEFLQPFSGGVWLTFALLLLLAGCLLWVTFILERRKQWKP---- 353

  Fly   417 MSYMDTLNFVWGAMCQQGFYVEVRNRSARIIVFTTFVAALFLFTSFSANIVA-LLQSP-SDAIQS 479
             |.:.:....:||.|.||.::..|:...|:..|...|.:..::..:::.:|: ||..| ...|::
  Fly   354 -SLLTSCLLSFGAGCIQGAWLTPRSMGGRMAFFALMVTSYLMYNYYTSIVVSKLLGQPIKSNIRT 417

  Fly   480 LSDLGQSPLEIGVQDTQYNKIYFTESTDPVTKNLYHKKI-ASK--GENIYMRPLLGMEKMR--TG 539
            |..|..|.|::|::.|.|.:||...|.:|..::||.||: .||  .:.|::....|:..:|  .|
  Fly   418 LQQLADSNLDVGIEPTVYTRIYVETSEEPDVRDLYRKKVLGSKRSPDKIWIPTEAGVLSVRDQEG 482

  Fly   540 LFAYQVELQAGYQIVSDTFSEPEKCGLMELEPFQLPMLAIPTR----------KNFPYKELIRRQ 594
             |.|...:..||:.|...|...:.|.|.|          ||.|          |..||.|||:..
  Fly   483 -FVYITGVATGYEFVRKHFLAHQICELNE----------IPLRDASHTHTVLAKRSPYAELIKLS 536

  Fly   595 LRWQREVSLVNREERKWIPQKPKCEGGVGGFVSIGITECRYALGIF 640
            .....|..:..:.||.|:..|..|... ...|::|:   .||..:|
  Fly   537 ELRMLETGVHFKHERSWMETKLHCYQH-NHTVAVGL---EYAAPLF 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75d	NP_649074.2	Periplasmic_Binding_Protein_Type_2	299..>483	CDD:304360	47/213 (22%)
Ir75d	NP_649074.2	Lig_chan	388..644	CDD:278489	72/276 (26%)
Ir75b	NP_001137966.2	Periplasmic_Binding_Protein_Type_2	253..553	CDD:304360	82/315 (26%)
Ir75b	NP_001137966.2	Lig_chan	343..585	CDD:278489	67/256 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462754
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740