DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75d and GLR1.4

DIOPT Version :9

Sequence 1:	NP_649074.2	Gene:	Ir75d / 40065	FlyBaseID:	FBgn0036829	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	NP_187408.2	Gene:	GLR1.4 / 819940	AraportID:	AT3G07520	Length:	861	Species:	Arabidopsis thaliana

Alignment Length:	762	Identity:	130/762 - (17%)
Similarity:	250/762 - (32%)	Gaps:	234/762 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 WRSEYSRQDPDPKTRWGNQLPDMLVAYYRHHGVH--------------------------SLMLV 65
            ||:.....:.|...|...|   .||.:::.:.:|                          .:.:.
plant   178 WRTAVLIYEDDDDWRESIQ---PLVGHFQQNAIHIEYKAEFSVSSNEECIMKQLRKFKASGIRIF 239

  Fly    66 VCHTD--IADFRLWKLWQHFN-LNNFYVQVSTESSLRDLQHVDALDEHK---------DAPPPKS 118
            |.|..  ||: ||:...:... :...|..:.|..|:.:.|..:.|.:.:         ..|..:.
plant   240 VAHISERIAN-RLFPCARRLGMMEEGYAWILTARSMNNFQDTNYLAKEEMEGVIGFKSYIPLTEE 303

  Fly   119 FHANNSTHWETSFLLPALPYKMGILLLEFSSECALNLLRWSAASEHNYFTTNRFWLLLTEDP--- 180
            .| |.:..|:.|..|..:..:|.:..: ::.:.|.:|.|   |:|.........:.||...|
plant   304 LH-NFTLRWKRSLRLEEVVTRMSVCSI-WAHDIAWSLAR---AAEVAKLPGLSVYDLLEAIPESA 363

  Fly   181 ------GDIDLLEDPEIFIPPDSEL--------RVLHYENVGNF------SCSLIDLYKVAAWKP 225
                  |||..::  :.||....|:        |.:...|.|:|      ..|.....:...| |
plant   364 KHKGLSGDIKFID--KKFISDKFEIVNMIGRGERSVGLWNSGSFISNRRRRLSSTKALETIIW-P 425

  Fly   226 LKRTLVG--HNIRNSRH------------------VIHALQHFGSAIT----YRQDLEGIVFNSA 266
            ...|.:.  .:::..||                  ::.....|.:.:|    |..|    ||.::
plant   426 GGSTRIPKIRSLKEKRHGKKKKLRVLVPAGNITPQILEVKTDFKTGVTAATGYCID----VFETS 486

  Fly   267 IVIAFPDLFTNIEDLSLRHIDTISKVNHRLMLELANRLNMSYNTYQTVNYGWRQPNGSFDGLMGR 331
            |      |..|.|   :.:|.....:|::      |..::.|..|.
plant   487 I------LPFNYE---VEYIPWPGAINYK------NYNDLVYTLYS------------------- 517

  Fly   332 FQRYELDLAQLAIFMRLDRIALVDFVAETYRVRAGIMFRQPPLSAVAN------IFAMPFENDVW 390
             |:.:.|.|...|.:..:|...|||.         :.|....|:.|..      |...|....:|
plant   518 -QKDKYDAAVGDITITDNRSLYVDFT---------LPFTDMGLAVVTAKDKSMWIIFKPLTLSLW 572

  Fly   391 VSILMLLIIT-TVVLVLELFFSPHNHDMSYMDTLNFVWGAMCQQ-------GFYV-------EVR 440
            ::|....|:| .:|.::|      .||.:...      |:..||       ||..       .::
plant   573 LTIASFFILTGAIVWLIE------RHDNADFQ------GSCFQQIGTLLCFGFSTLVFAHRERLQ 625

  Fly   441 NRSARIIVFTTFVAALFLFTSFSANIVALLQSPSDAIQSLSDLGQSPLEIGVQDTQYNKIYFTES 505
            :..:|.:|.....|.|.|.::::|.:.:::     .:|.:..| :|...||         :|:.|
plant   626 HNMSRFVVIVWIFAVLILTSNYTATLTSVM-----TVQQIRGL-KSNENIG---------FFSAS 675

  Fly   506 TDPVTKNLYHKKIASKGENIYMRPLLGME-------KMRTGLFAYQVELQAGYQIVSDTFSEPEK 563
               :..|:.:.....:|..     ..|::       .:|.|..::.|: :..| :.......|.:
plant   676 ---IAANVVNDNPTFQGPR-----YKGLKTADDFTNALRNGTISFIVD-EVPY-VKLFVAKHPSE 730

  Fly   564 CGLMELE--------PFQLPMLAIPTRKNFPYKELIRRQLRWQREVSLVNREERKWIPQKPKCEG 620
            ..::|.|        .||         |..|..:.:.|::...|....:...|..|..::.....
plant   731 FVIVETESVTNGFGFAFQ---------KGSPLVQKVSREIEKLRRTEKLKAIENWWFQRQTTSAT 786

  Fly   621 GVGGFVSIGITECRYALGIFGCGAAVSFVLFLF-------EFIFRHF 660
            ....|..:.:...|....|.|...|.:.:::|.       :.:.:||
plant   787 SEDTFHPLTVYTFRGLFMITGVSFAFALIVYLIPWNREQRQVVLKHF 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75d	NP_649074.2	Periplasmic_Binding_Protein_Type_2	299..>483	CDD:304360	36/204 (18%)
Ir75d	NP_649074.2	Lig_chan	388..644	CDD:278489	48/285 (17%)
GLR1.4	NP_187408.2	PBP1_GABAb_receptor	47..410	CDD:107361	44/242 (18%)
		ANF_receptor	64..390	CDD:279440	40/222 (18%)
		GluR_Plant	448..778	CDD:270404	71/423 (17%)
		Periplasmic_Binding_Protein_Type_2	476..>657	CDD:304360	45/245 (18%)
		Lig_chan	570..810	CDD:278489	48/285 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000