DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir75d and GLR5

DIOPT Version :9

Sequence 1:	NP_649074.2	Gene:	Ir75d / 40065	FlyBaseID:	FBgn0036829	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	NP_565744.1	Gene:	GLR5 / 817801	AraportID:	AT2G32400	Length:	921	Species:	Arabidopsis thaliana

Alignment Length:	767	Identity:	144/767 - (18%)
Similarity:	248/767 - (32%)	Gaps:	240/767 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 NLNNFY-----VQVSTESSLRDLQHVDALDEHKDAPPPK-SFHANNSTHWETSFLLPALPYKMGI 142
            :|.|||     :.|.::..| ....|.|||:.......: |:....|.|.:..||..||.....|
plant   156 DLINFYGWKEVISVYSDDEL-GRNGVSALDDELYKKRSRISYKVPLSVHSDEKFLTNALNKSKSI 219

  Fly   143 ----LLLEFSSECALNLLRWSAASE---HNYFTTNRFWLLLT----EDPGDIDLLEDP---EIFI 193
                .:|.|..:..|.:...:...:   |.|......||.:|    .|.|.:..||..   ...|
plant   220 GPRVYILHFGPDPLLRIFDIAQKLQMMTHEYVWLATDWLSVTLDSLSDKGTLKRLEGVVGLRQHI 284

  Fly   194 PPDSELRVLHYENVGNFSCSLIDLYKV-AAWKPLKRTLVGHNIRN------------SRHVIHAL 245
            |...::....::...|.|.:...|:.. ..|      ::.|.|..            |..::||.
plant   285 PESVKMEHFTHKLQSNRSMNAYALHAYDTVW------MIAHGIEELLNEGINITFSYSEKLLHAR 343

  Fly   246 QHFGSAITYRQDLEGI-VFNSAIVIAFPDLFTNIEDLSLRHIDTISKVNHRLM---LELANRLNM 306
               |:.:    .||.| .|||..::                ::.:.|||...:   ::..:..|:
plant   344 ---GTKL----HLEKIKFFNSGELL----------------LEKLLKVNFTGIAGQVQFGSGRNV 385

  Fly   307 SYNTYQTVN--------YGWRQPNGSFDGLM--------------------------GRFQRYEL 337
            ....|:.:|        .|:...||.|..:.                          ||.:....
plant   386 IGCDYEIINVNKTDVHTVGFWSKNGGFSVVAPKTRHSQKKTSFVSDEKLGDITWPGGGREKPRGW 450

  Fly   338 DLAQLAIFMRL---DRIALVDFVAE----TYRVRA------------------------------ 365
            .:|..|..:::   .|::.|:||.|    ::|::.
plant   451 VIADSADPLKIVVPRRVSFVEFVTEEKNSSHRIQGFCIDVFIEALKFVPYSVPYIFEPFGNGHSS 515

  Fly   366 ------------GIM------------------FRQPPLSA------VAN------IFAMPFEND 388
                        |:.                  |.||..|.      .||      ||..||.:.
plant   516 PNYNHLIQMVTDGVYDAAVGDIAIVPSRSKLVDFSQPYASTGLVVVIPANDDNATWIFLRPFTSR 580

  Fly   389 VWVSILM-LLIITTVVLVLEL-----FFSPHNHDMSYMDTLNFVWGAMCQQGFYVEVRNRSARII 447
            :|..:|: .|:|..|:.:||.     |..|....:|.|  |.|.:..:.::.....:.| .||::
plant   581 LWCVVLVSFLVIAVVIWILEHRINEDFRGPPRRQLSTM--LLFSFSTLFKRNQEDTISN-LARLV 642

  Fly   448 VFTTFVAALFLFTSFSANIVALL---QSPSDAIQSLSDLGQSPLEIGVQDTQYNKIYFTESTD-- 507
            :.......:.|..|::||:.::|   |.|| ||..:..|..|.:.||.|...:...|.|.|..
plant   643 MIVWLFLLMVLTASYTANLTSILTVQQLPS-AITGIDSLRASEVPIGYQAGTFTLEYLTYSLGMA 706

  Fly   508 -----PVTKNLYHKKIASKGENIYMRPLLGMEKMRTGLFAYQVEL---------QAGYQIVSDTF 558
                 |:.....::|....|...:           .|:.|...||         :.|::||.
plant   707 RSRLVPLDSTEEYEKALKLGPTNW-----------GGVAAIVDELPYIELFLAERTGFKIVG--- 757

  Fly   559 SEPEKCGLMELEPFQLPMLAIPTRKNFPYKELIRRQLRWQREVSLVNREERKWIPQKPKCEGGVG 623
                       |||.........:::.|....:...:....|...:....:||: .|..|.|...
plant   758 -----------EPFMHRGWGFAFKRDSPLAIDMSTAILKLSETRKLQEIRKKWL-CKTNCAGKSN 810

  Fly   624 GFVSIGITECRYALGIFGCGAAVSFVLFLFEFIFRHFKQVYRIIKGYREVQR 675
            ..........:...|::....|::...||. |:.|..:|..|    ||.::|
plant   811 WNPEPNQLHLKSFKGLYLVCIAITVSAFLV-FVLRMIRQFVR----YRRMER 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75d	NP_649074.2	Periplasmic_Binding_Protein_Type_2	299..>483	CDD:304360	54/305 (18%)
Ir75d	NP_649074.2	Lig_chan	388..644	CDD:278489	55/280 (20%)
GLR5	NP_565744.1	PBP1_GABAb_receptor	32..416	CDD:107361	58/289 (20%)
		ANF_receptor	46..396	CDD:279440	54/269 (20%)
		GluR_Plant	458..800	CDD:270404	67/370 (18%)
		Lig_chan	581..832	CDD:278489	55/280 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000