DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75d and grik5

DIOPT Version :9

Sequence 1:	NP_649074.2	Gene:	Ir75d / 40065	FlyBaseID:	FBgn0036829	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	NP_001315085.1	Gene:	grik5 / 798791	ZFINID:	ZDB-GENE-070821-6	Length:	1067	Species:	Danio rerio

Alignment Length:	661	Identity:	148/661 - (22%)
Similarity:	259/661 - (39%)	Gaps:	162/661 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 FYVQVSTESSLRDLQHVDALDEHKDAPPPKSFHANNSTHWETSFLLPALPYKMGILLLEFSSECA 152
            ||..:.|......|...|.:||..:.   ..|...|:||          |:     .|||..  :
Zfish   252 FYKYILTTMDFPLLWLDDIVDEQSNI---VGFSMFNTTH----------PF-----YLEFIR--S 296

  Fly   153 LNLLRWSAASEHNYFTTNRFWLLLTEDPG----DIDLLEDPEIFIPPDSELRVLHYENVGNFSC- 212
            || |.|....:.|.:            ||    ...|.:...:.:....||.......|...||
Zfish   297 LN-LSWREGCDINPY------------PGPALSSALLFDAVHVVVSAVQELNRSQEIGVKPLSCT 348

  Fly   213 ---------SLIDLYKVAAWKPLKRTLVGHNIRNSR--HVIHALQ-HFGSAITYRQDLEGIVF-N 264
                     ||::..::..:..|... |..|.:..|  :.:|.|: |.|.    .::: ||.: |
Zfish   349 SPQIWQHGTSLMNYLRMVEYDGLTGR-VEFNSKGQRTNYTLHILEKHRGG----HKEI-GIWYSN 407

  Fly   265 SAIVIAFPDLFTNI-EDLSLRH--IDTI-------SKVNHR--------------LMLELANRLN 305
            :.:::....|..|: |.|:.:.  |.||       .|:|::              ::.||::.|.
Zfish   408 NTLLMNSTSLDINVSETLANKSLIITTILENPYVMRKINYQEFEGNEQYEGFCVDMLRELSDILK 472

  Fly   306 MSYNTYQTVN---YGWRQPNGSFDGLMGRFQRYELDLAQLAIFMRLDRIALVDF--------VAE 359
            .:|. .:.|:   ||..:||||:.|::|.....:.|||..|..:..:|..::||        ::.
Zfish   473 FTYR-IKLVDDGLYGAPEPNGSWTGMVGELINRKADLAVAAFTITSEREKVIDFSKPFMTLGISI 536

  Fly   360 TYRVRAGIMFRQPPLSAVANIFAMPFENDVWVSILMLLIITTVVLVLEL------FFSPHNHDMS 418
            .|||..|   |:|...:    |..||...||:.:|:..:..:.||.|..      :::||.....
Zfish   537 LYRVHIG---RKPGYFS----FLDPFSPAVWLFMLLAYLAVSCVLFLSARLSPYEWYNPHPCLRE 594

  Fly   419 YMDTL-------NFVW---GAMCQQGFYVEVRNRSARIIVFTTFVAALFLFTSFSANIVALL--Q 471
            ..|.|       |.:|   |...|||..:..|..|.|.:....:...|.:.:|::||:.|.|  |
Zfish   595 RRDLLENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQ 659

  Fly   472 SPSDAIQSLSDLG-QSPLEIGVQDTQYNKIYFTESTDPVTKNLYHKKIASKGENIYMRPL-LGME 534
            .....|:|..||. |:.::.|.........:|..|.....:.::: .:.||..:::::.. .|:.
Zfish   660 RMEVPIESPDDLADQTNIQYGTIHGGSTMTFFMNSRYQTYQRMWN-YMYSKQPSVFVKSTEEGIA 723

  Fly   535 KMRTGLFAYQVELQAGYQIVSDTFSEPEK---C------GLMELEPFQLPM-LAIPTRKNFPYKE 589
            ::....:|:.:|         .|.:|..:   |      ||::.:.:.:.| |..|.|.......
Zfish   724 RVVNSKYAFLLE---------STMNEYHRSLNCNLTQIGGLLDTKGYGIGMPLGSPFRDELSLAV 779

  Fly   590 LIRRQLRWQREVSLVNREERKWIPQK-PKCEG----GVGGFVSIGITECRYALGIFG---CGAAV 646
            |   ||:....:.::.|  |.|...| ||.|.    |: |..:||        |||.   ||..:
Zfish   780 L---QLQENNRLEILKR--RWWEGGKCPKEEDHRAKGL-GMENIG--------GIFVVLICGLII 830

  Fly   647 SFVLFLFEFIF 657
            :..:.:.||::
Zfish   831 AVFVAVMEFVW 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75d	NP_649074.2	Periplasmic_Binding_Protein_Type_2	299..>483	CDD:304360	57/212 (27%)
Ir75d	NP_649074.2	Lig_chan	388..644	CDD:278489	66/293 (23%)
grik5	NP_001315085.1	PBP1_iGluR_Kainate_KA1_2	38..412	CDD:107389	41/198 (21%)
		ANF_receptor	55..392	CDD:279440	35/173 (20%)
		Periplasmic_Binding_Protein_Type_1	<313..383	CDD:299141	11/70 (16%)
		Periplasmic_Binding_Protein_Type_2	427..797	CDD:304360	87/392 (22%)
		Lig_chan	558..828	CDD:278489	66/293 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591574
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840