DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75d and gria1a

DIOPT Version :9

Sequence 1:	NP_649074.2	Gene:	Ir75d / 40065	FlyBaseID:	FBgn0036829	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	NP_991161.1	Gene:	gria1a / 798689	ZFINID:	ZDB-GENE-020125-1	Length:	914	Species:	Danio rerio

Alignment Length:	769	Identity:	153/769 - (19%)
Similarity:	258/769 - (33%)	Gaps:	232/769 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 QHFNLNNFYVQVSTESSLRDLQHV-DALDEHKDAPPPKSFHANNSTHWETSFLLPALPY---KMG 141
            :|:..:.|....|::|.|..||.| |...||.....    ..|..|..|.|||......   |.|
Zfish   137 EHYRWSKFVYMYSSDSGLSVLQKVLDTAAEHNWLVT----SVNVETMTEASFLKVFQDLDKKKEG 197

  Fly   142 ILLLEFSSECALNLLR-----WSAASEHNYFTTNRFWLLLTEDPGDIDLLE-------------- 187
            .::::...|...::|:     ......::|...|..:|       ||||.|
Zfish   198 QIIIDCELERLTSILKKIIELGKNVKSYHYILANLGFL-------DIDLTEFKKGEANVTGFQLV 255

  Fly   188 ---DPEI---------FIPPDSEL--RVLHYE-----------------------------NVG- 208
               ||.:         |...|:::  |.|.|.                             |.|
Zfish   256 NYADPNVSRTVQQWMEFDNKDAKVPKRRLKYTGALTYDGVKVMSTAFQNLRRQRIDISRRGNAGE 320

  Fly   209 ----------------------------------------NFSCSLIDLYKVAAWKPLKRTLVGH 233
                                                    |:|.|:::|      :|.....||:
Zfish   321 CLANPPAPWGQGIDIQRALQQVRIEGLTGHIQFNEKGRRTNYSISVMEL------RPTGPKKVGY 379

  Fly   234 NIRNSRHVIHALQHFGSAITYRQDLEGIVFNSAIVIAFPDLFTNIEDLSLRHIDTISKVNH---- 294
            ...:.:.|..|....||..||     |:...:.||       |.|    |.....:.|.||
Zfish   380 WNEDEKFVSTAAYMPGSNETY-----GLQNRTYIV-------TTI----LESPYVMLKKNHEHFT 428

  Fly   295 ----------RLMLELANRLNMSY--NTYQTVNYGWRQPNG-SFDGLMGRFQRYELDLAQLAIFM 346
                      .|..|:|..:...|  .......||.|.... .::|::|.....:.|:|...:.:
Zfish   429 GNDKYEGYCVELAAEIAKHVGYHYILKIVADGKYGARDAETMMWNGMVGELVYGKADVAVAPLTI 493

  Fly   347 RLDRIALVDFVAETYRVRAGIMFRQPPLSAVANIFAM--PFENDVWVSILMLLIITTVVLVLELF 409
            .|.|..::||......:...||.::|..|. ..:|:.  |...::|:.|:...|..:|||.|...
Zfish   494 TLVREEVIDFSKPFMSLGISIMIKKPTKSK-PGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSR 557

  Fly   410 FSPH---------------------------------------NHDMSYMDTLNFVWGAMCQQGF 435
            |||:                                       .::....::|.|..||..|||.
Zfish   558 FSPYEWHADDCEDGAEENPNQPSSSSAQPGQNQQNQNQQSQEQTNEFGIFNSLWFSLGAFMQQGC 622

  Fly   436 YVEVRNRSARIIVFTTFVAALFLFTSFSANIVALLQ-----SPSDAIQSLSDLG-QSPLEIGVQD 494
            .:..|:.|.||:....:...|.:.:|::||:.|.|.     ||   |:|..||. |:.:..|..|
Zfish   623 DISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSP---IESAEDLAKQTEIAYGTLD 684

  Fly   495 TQYNKIYFTESTDPVTKNLYHKKIASKGENIYMRPL-LGMEKMR--TGLFAYQVELQAGYQIVSD 556
            ....|.:|..|...|.:.:: ..:.|...:::::.. .|:.::|  .|.:||.:|     ..:::
Zfish   685 AGSTKEFFRRSKIAVFEKMW-SYMKSADPSVFVKTTDEGVMRVRKSKGKYAYLLE-----STMNE 743

  Fly   557 TFSEPEKCGLMEL-EPFQLPMLAIPTRKNFPYKELIRRQLRWQREVSLVNREERKWIPQKPKCEG 620
            ...:.:.|..|:: .........|.|.|..|.:..:...:....|..|:::.:.||...|.:|
Zfish   744 YIEQRKPCDTMKVGGNLDSKGYGIATPKGSPLRNPVNLAVLKLNEQGLLDKLKNKWWYDKGEC-- 806

  Fly   621 GVGGFVSIGITECRYALGIFGC------GAAVSFVLFLFEFIF------RHFKQ 662
            |.||..|...|.......:.|.      |..::.::.|.||.:      |..||
Zfish   807 GSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALVEFCYKSRTESRRMKQ 860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75d	NP_649074.2	Periplasmic_Binding_Protein_Type_2	299..>483	CDD:304360	51/232 (22%)
Ir75d	NP_649074.2	Lig_chan	388..644	CDD:278489	65/310 (21%)
gria1a	NP_991161.1	Periplasmic_Binding_Protein_Type_1	26..387	CDD:299141	45/266 (17%)
		ANF_receptor	36..369	CDD:279440	41/242 (17%)
		PBP2_iGluR_AMPA_GluR1	404..806	CDD:270447	87/422 (21%)
		Lig_chan	536..836	CDD:278489	65/310 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591472
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.840