DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75d and grik1a

DIOPT Version :9

Sequence 1:	NP_649074.2	Gene:	Ir75d / 40065	FlyBaseID:	FBgn0036829	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	XP_009303592.1	Gene:	grik1a / 798001	ZFINID:	ZDB-GENE-030131-6502	Length:	919	Species:	Danio rerio

Alignment Length:	398	Identity:	83/398 - (20%)
Similarity:	169/398 - (42%)	Gaps:	48/398 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   296 LMLELANRLNMSYNTYQTVN--YGWRQPNGSFDGLMGRFQRYELDLAQLAIFMRLDRIALVDFVA 358
            |:.||:|.|..:|......:  ||.:...|.::|::.....:..|||...:.:...|..::||..
Zfish   482 LLKELSNILGFTYEVKLVTDGKYGAQNDKGEWNGMVRELIDHIADLAVAPLTITYVREKVIDFSK 546

  Fly   359 ETYRVRAGIMFRQPPLSAVANIFAM--PFENDVWVSILMLLI-ITTVVLVLELF-----FSPH-- 413
            ....:...|::|:|. .....:|:.  |...|:|:.:|:..: ::.|:.|:..|     ::||
Zfish   547 PFMTLGISILYRKPN-GTNPGVFSFLNPLTPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPC 610

  Fly   414 -------NHDMSYMDTLNFVWGAMCQQGFYVEVRNRSARIIVFTTFVAALFLFTSFSANIVALL- 470
                   .::.:.:::|.|...|:.:||..:..:..|.||:....:...|.:.:|::||:.|.|
Zfish   611 NPSSEVVENNFTLLNSLWFGVAALMRQGSELMPKALSTRILGGIWWFFTLIIISSYTANLAAFLT 675

  Fly   471 ----QSPSDAIQSLSDLGQSPLEIGVQDTQYNKIYFTESTDPVTKNLYHKKIASKGENIYMRPLL 531
                .||.|:...|:.  |:.:|.|.........:|.:|.....:.::....:.|...:......
Zfish   676 VERMDSPIDSADDLAK--QTRIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRKNTALVKNSKD 738

  Fly   532 GMEKMRTGLFAYQVELQAGYQIVSDTFSEPEKCGLMELEPFQLPMLAIPTRKNFPYKELIR-RQL 595
            |:.::.|..:|..:|..:...|.....:..:..||::.:.:     .:.|....||::.:. ..|
Zfish   739 GITRVLTTDYALLMESTSIEYITQRNCNLTQVGGLIDSKGY-----GVGTPIGSPYRDKVTIAIL 798

  Fly   596 RWQREVSLVNREERKW----IPQKPKCEGGVGGFVSIGITECRYALGIF---GCGAAVSFVLFLF 653
            :.|.|..|...:|:.|    .|::...|....|..:||        |||   ..|..:|..:.:.
Zfish   799 QLQEEGKLHMMKEKWWRGNGCPEEDSKEASALGVENIG--------GIFIVLAAGLVLSVFVAIG 855

  Fly   654 EFIFRHFK 661
            |||::..|
Zfish   856 EFIYKSHK 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75d	NP_649074.2	Periplasmic_Binding_Protein_Type_2	299..>483	CDD:304360	46/207 (22%)
Ir75d	NP_649074.2	Lig_chan	388..644	CDD:278489	56/283 (20%)
grik1a	XP_009303592.1	Periplasmic_Binding_Protein_Type_1	37..432	CDD:299141
		ANF_receptor	57..398	CDD:279440
		Periplasmic_Binding_Protein_Type_2	446..815	CDD:304360	68/340 (20%)
		Lig_chan	577..846	CDD:278489	56/283 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591528
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740