Protein Alignment Ir75d and grin2aa

DIOPT Version :10

• Sequence 1: NP_649074.2
• Gene: Ir75d / 40065
• FlyBaseID: FBgn0036829
• Length: 675
• Species: Drosophila melanogaster
• Sequence 2: XP_021329529.1
• Gene: grin2aa / 563297
• ZFINID: ZDB-GENE-070424-129
• Length: 1460
• Species: Danio rerio
• Alignment Length: 578
• Identity: 108/578 - (18%)
• Similarity: 200/578 - (34%)
• Gaps: 161/578 - (27%)

  Fly   170 NRFWLLLTEDPGDIDLLED-----PE---IFIPPDSELRVLHYENVGNFSCSLIDLYKVAAWKPL 226
            :::.:.:|.|..|:...||     |:   |.:..|.|     :|.:|.:....:.| |...|...
Zfish   332 HKYMMNVTWDGKDLSFTEDGYQVHPKLVVIVLNKDRE-----WEKMGKWENQSLTL-KYPVWPRF 390

  Fly   227 KRTLVGHNIRNSRHVIHALQHFGSAITYRQDLEGIVFNSAIVIAFPDLFTNIEDLS--------- 282
                      ||         ||.|.|....|..:.......:    :..|:|.|:
Zfish   391 ----------NS---------FGDAETDDNHLTIVTLEEKPFV----IVENVERLTGTCMRNSVP 432

  Fly   283 -LRH---------------------IDTISKVNHRLMLELANRLNMSYNTYQTVN--YGWRQPNG 323
             .:|                     ||.:.|:        |..:..:|:.|...|  :| ::.|.
Zfish   433 CRKHIKDNTTEGGGTYIKKCCKGFCIDILKKI--------ARNVKFTYDLYLVTNGKHG-KKINN 488

  Fly   324 SFDGLMGRFQRYELDLAQLAIFMRLDRIALVDFVAETYRVRAGIMFRQPPLSAVANIFAMPFEND 388
            .::|::|.....:..:|..::.:..:|..::||..........:|..:...:...:.|..||...
Zfish   489 VWNGMVGEVVNKKAVMAVGSLTINEERSEVIDFSVPFVETGISVMVSRSNGTVSPSAFLEPFSAS 553

  Fly   389 VWVSI-LMLLIITTVVLVLELFFS-------------PHNHDMSYMDTLNFVWGAMCQQGFYVEV 439
            |||.: :|||::|.:.:.:..:.|             ||....:....:..:||.:....  |.|
Zfish   554 VWVMMFVMLLLVTAMAVFMFEYISPLGFNRNLAQGKDPHGPSFTMGKAVWLLWGLVFNNS--VPV 616

  Fly   440 RN----RSARIIVFTTFVAALFLFTSFSANIVALL--QSPSDAIQSLSDLG-QSPLEIGVQDTQY 497
            :|    .|..|:....|.|.:|| .|::||:.|.:  :...|.:..|||.. |||......
Zfish   617 QNPKGTTSKFIVSVWAFFAVIFL-ASYTANLAAFMIQEEFVDQVTGLSDKKFQSPYSYSPP---- 676

  Fly   498 NKIYFTESTDP-------VTKNL-----YHKKIASKGENIYMRPLLGMEKMRTGLFAYQ------ 544
                |...|.|       :.||.     |..|....|.|   ..|:.::..:...|.|.
Zfish   677 ----FRFGTVPNGSTERNIRKNYPDMHQYMVKYHQTGVN---DALVSLKTGKLDAFIYDAAVLNY 734

  Fly   545 ----------VELQAGYQIVSDTFSEPEKCGLMELEPFQLPMLAIPTRKNFPYKELIRRQLRWQR 599
                      |.:.:||...:..:....:.|.:...|..|.:|||     ....|:...:.:|.
Zfish   735 MAGRDEGCKLVTIGSGYIFATTGYGIALQKGSLWKRPVDLAILAI-----IGDGEMEELEAQWL- 793

  Fly   600 EVSLVNREERKWIPQKPKCEGGVGGFVSIGITECRYALGIFGCGAAVSFVLFLFEFIF 657
             ..:.:.|:.:.:..:...:...|.|..:..     |:|:       |.:.|::|.:|
Zfish   794 -TGICHNEKNEVMSSQLDVDNMAGVFYMLAT-----AMGL-------SLITFVWEHLF 838

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75d	NP_649074.2	Periplasmic_Binding_Protein_Type_2	299..>372	CDD:473866	13/74 (18%)
		Lig_chan	386..643	CDD:459656	60/305 (20%)
grin2aa	XP_021329529.1	PBP1_iGluR_NMDA_NR2	33..384	CDD:380601	12/57 (21%)
		PBP2_iGluR_NMDA_Nr2	400..799	CDD:270436	79/432 (18%)
		NMDAR2_C	836..1460	CDD:463148	1/3 (33%)