DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75d and grin2bb

DIOPT Version :9

Sequence 1:	NP_649074.2	Gene:	Ir75d / 40065	FlyBaseID:	FBgn0036829	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	NP_001121809.1	Gene:	grin2bb / 559976	ZFINID:	ZDB-GENE-061207-27	Length:	1770	Species:	Danio rerio

Alignment Length:	420	Identity:	89/420 - (21%)
Similarity:	159/420 - (37%)	Gaps:	87/420 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   286 IDTISKVNHRLMLELANRLNMSYNTYQTVN--YGWRQPNGSFDGLMGRFQRYELDLAQLAIFMRL 348
            ||.:.|:        |..:..:|:.|...|  :| ::.||:::|::|........:|..::.:..
Zfish   541 IDILKKI--------AKSVKFTYDLYLVTNGKHG-KKINGTWNGMVGEVVLKNAHMAVGSLTINE 596

  Fly   349 DRIALVDFVAETYRVRAGIMFRQPPLSAVANIFAMPFENDVWVSI-LMLLIITTVVLVLELFFSP 412
            :|..::||..........:|..:...:...:.|..||..||||.: :||||::.|.:.:..:|||
Zfish   597 ERSEVIDFSVPFIETGISVMVSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSP 661

  Fly   413 HNHDMSYMD-------------TLNFVWGAMCQQGFYVEVRN---RSARIIVFT-TFVAALFLFT 460
            ..::....|             .:..:||.:....  |.|:|   .:::|:|.. .|.|.:|| .
Zfish   662 VGYNRCLADGREPGGPSFTIGKAIWLLWGLVFNNS--VPVQNPKGTTSKIMVSVWAFFAVIFL-A 723

  Fly   461 SFSANIVALL--QSPSDAIQSLSDLG-------QSPLEIGVQDTQYNKIYFTESTDPVTKNLY-- 514
            |::||:.|.:  :...|.:..|||..       ..|...|...        ..||:...:|.|
Zfish   724 SYTANLAAFMIQEEYVDQVTGLSDKKFQHPNDFSPPFRFGTVP--------NGSTERNIRNNYKE 780

  Fly   515 -HKKIASKGENIYMRPLLGMEKMRTGLFAYQVELQAGYQIVSDTFSEPEKCGLMELEPFQLPMLA 578
             |..:.|..:......|..::..:...|.|...: ..|....|     |.|.|          :.
Zfish   781 MHSYMTSFHQKNVNEALHSLKSGKLDAFIYDAAV-LNYMAGRD-----EGCKL----------VT 829

  Fly   579 IPTRKNFP---YKELIRRQLRWQREVSL----------VNREERKWIPQKPKCEGGVGGFVSIGI 630
            |.:...|.   |...|::...|:|.|.|          :...|..|:  ...|.......:|..:
Zfish   830 IGSGYIFATTGYGIAIQKDSGWKRAVDLAILQLFGDGEMEELEALWL--TGICHNEKNEVMSSQL 892

  Fly   631 TECRYALGIF---GCGAAVSFVLFLFEFIF 657
            .....| |:|   |...|:|.:.|:.|.:|
Zfish   893 DVDNMA-GVFYMLGAAMALSLITFIAEHLF 921

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75d	NP_649074.2	Periplasmic_Binding_Protein_Type_2	299..>483	CDD:304360	48/205 (23%)
Ir75d	NP_649074.2	Lig_chan	388..644	CDD:278489	64/301 (21%)
grin2bb	NP_001121809.1	PBP1_iGluR_NMDA_NR2	107..470	CDD:107373
		ANF_receptor	138..442	CDD:279440
		PBP2_iGluR_NMDA_Nr2	482..882	CDD:270436	79/378 (21%)
		Lig_chan	636..908	CDD:278489	64/301 (21%)
		NMDAR2_C	919..1770	CDD:287527	1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591402
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.830