Protein Alignment Ir75d and grik4

DIOPT Version :10

• Sequence 1: NP_649074.2
• Gene: Ir75d / 40065
• FlyBaseID: FBgn0036829
• Length: 675
• Species: Drosophila melanogaster
• Sequence 2: XP_021322088.1
• Gene: grik4 / 556582
• ZFINID: ZDB-GENE-070821-5
• Length: 965
• Species: Danio rerio
• Alignment Length: 680
• Identity: 144/680 - (21%)
• Similarity: 248/680 - (36%)
• Gaps: 198/680 - (29%)

  Fly    89 YVQVSTESSLRDLQHVDALDEHKDAPPPKSFHANNSTHWETSFLLPALPYKMGILLLEFSSECAL 153
            |:..|.|.||..|.  |..|:..:.   ..|...|.||                   .|..:..|
Zfish   243 YILTSLEFSLLRLD--DLADQRVNI---VGFSVFNRTH-------------------PFFQDFVL 283

  Fly   154 NLLR-WSAASEHNYFTTNRFWLLLTEDPGDIDLLEDP-EIFIPPDSELRVLHYENVG--NFSC-- 212
            :|.| |....:|..|...         |....||.|. ...:....||.  ..:|||  ..||
Zfish   284 SLNRSWQENCDHAPFAGT---------PLSSALLFDAVHTVVAAVQELN--RSQNVGATQLSCKS 337

  Fly   213 --------SLIDLYKVAAWKPLKRTLVGHNIRNSR-----HVIHALQ------------HFGSAI 252
                    ||::..::...:    .|.||...||:     :.:..:|            |....:
Zfish   338 SKIWEHGTSLMNYLRMVELE----GLTGHIEFNSKGQRSNYALRIMQNSRDGLRQIGQWHSEQGL 398

  Fly   253 TYRQDLEGI-----VFNSAIVIAFPDLFTNIEDLSLRHIDTISKVNHR--------------LML 298
            :..:.|..:     :||:.:.|      |.|    |.:...:.:.||:              ::.
Zfish   399 SMERKLPSLNVTDTLFNTTLTI------TTI----LENPYVMLRANHQELEGNDRYEGFCVDMLK 453

  Fly   299 ELANRLNMSYNTYQTVN--YGWRQPNGSFDGLMGRFQRYELDLAQLAIFMRLDRIALVDF----- 356
            |||:.|...|......:  ||....||::.|::|.....:.|||..|:.:..:|..::||
Zfish   454 ELADILKFKYRIRLVGDGVYGVPGANGTWTGMVGELISRKADLAVAALTITAEREKVIDFSKPFM 518

  Fly   357 ---VAETYRVRAGIMFRQPPLSAVANIFAMPFENDVWVSILMLLIITTVVLVLEL------FFSP 412
               ::..|||..|   |:|...:    |..||...||:.:|:..:..:.||.|..      :::|
Zfish   519 TLGISIMYRVHIG---RRPGYFS----FLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYNP 576

  Fly   413 HN----------HDMSYMDTLNFVWGAMCQQGFYVEVRNRSARIIVFTTFVAALFLFTSFSANIV 467
            |.          :..|..::..|..|...|||..:..|..|.|.:....:...|.:.:|::||:.
Zfish   577 HPCLKGRCSLLINQYSLGNSFWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLA 641

  Fly   468 ALL-----QSPSDAIQSLSDLGQSPLEIGVQDTQYNKIYFTESTDPVTKNLYHKKIASKGENIYM 527
            |.|     :.|.:::..|:|  |:.:|.|.........:|..|.....:.::: .:.||..::::
Zfish   642 AFLTVQRMEVPIESVDDLAD--QTAIEYGTMHGGSTMTFFQNSRYQTYQRMWN-FMYSKQPSVFV 703

  Fly   528 RPL-LGMEKMRTGLFAYQVELQAGYQIVSDTFSE---PEKC------GLMELEPFQLPMLAIPTR 582
            :.. .|:.::....:||.:|         .|.:|   ...|      ||::.:.:.:.|
Zfish   704 KSTEEGIARVLNSNYAYLLE---------STMNEYYRQRNCNLTQIGGLLDTKGYGIGM------ 753

  Fly   583 KNFPYKELIRRQ-----LRWQREVSLVNREE---RKW-----IPQKPKCEGGVGGFVSIGITECR 634
               |...:.|.:     ||.|.|    ||.|   |||     .|::........|..:||
Zfish   754 ---PLGSVYRDEFDLAILRLQEE----NRLEILKRKWWDGGKCPKEEDHRAKGLGMENIG----- 806

  Fly   635 YALGIF---GCGAAVSFVLFLFEFIF--RH 659
               |||   .||..|:..:.:.||::  ||
Zfish   807 ---GIFVVLVCGLLVAIFMAVLEFVWMLRH 833

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir75d	NP_649074.2	Periplasmic_Binding_Protein_Type_2	299..>372	CDD:473866	23/82 (28%)
		Lig_chan	386..643	CDD:459656	62/303 (20%)
grik4	XP_021322088.1	Periplasmic_Binding_Protein_type1	24..401	CDD:471960	39/196 (20%)
		PBP2_iGluR_kainate_KA1	425..785	CDD:270442	84/391 (21%)