DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75d and grid2

DIOPT Version :9

Sequence 1:	NP_649074.2	Gene:	Ir75d / 40065	FlyBaseID:	FBgn0036829	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	NP_001004123.1	Gene:	grid2 / 448841	ZFINID:	ZDB-GENE-040913-1	Length:	1009	Species:	Danio rerio

Alignment Length:	645	Identity:	139/645 - (21%)
Similarity:	267/645 - (41%)	Gaps:	124/645 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 VVCHTDIADF-----------RLWKLWQHFNLNNFYVQVSTESSLRDLQHVD-ALDEHKDAPPPK 117
            ::.:.:|:|.           ||..:.|.|.|    .|.:::..:|:...:: :|.:.|| |..:
Zfish   259 IIINEEISDMDVQELVMKSIGRLTLVRQTFPL----PQNTSQRCVRNNHRINTSLCDPKD-PKAQ 318

  Fly   118 SFHANNSTHWETSFLLPALPYKMGILLLEFSSECALNLLR-----WSAASEHNYFTTNRFWLLLT 177
            .....|...::|..|| |..:...:...::.|..:|:.:|     |.....          :|.|
Zfish   319 MLEITNRYIYDTVLLL-ANTFHRKLEDRKWHSMASLSCIRKGSKPWQGGKS----------MLET 372

  Fly   178 EDPGDI----DLLEDPEIFIPPDSELRVLHYENVG-NFSCSLID----LYKVAAWKP---LKRTL 230
            ...|.:    .|||..:....|:     :|:|.:| |:.   .|    :.::|.|.|   |..||
Zfish   373 VKKGGVSGLTSLLEFNDNGSNPN-----IHFEILGTNYG---EDRGRGVSRLATWDPIHGLNGTL 429

  Fly   231 VGHNIRNSRHVIHALQHFGSAITYRQDLEGIVFNSAIVIAFPDLFTNIEDLSLRHIDTISKVNHR 295
            ....:.|                   ::.|:|.....|:..|  |..:.:..|.........:..
Zfish   430 TDRKLEN-------------------NMRGVVLRVVTVLEEP--FVMVSENVLGKPKKYQGFSID 473

  Fly   296 LMLELANRLNMSYNTYQTVN--YGWRQPNGSFDGLMGR--FQRYELDLAQLAIFMRLDRIALVDF 356
            ::..|||.|...|..|...:  ||.:|.:|:::||:|.  |:|.::.|:.|.|  ..:|.::|||
Zfish   474 VLDALANYLGFKYEIYVAPDHKYGSQQADGTWNGLIGELVFKRADVGLSALTI--TPERESVVDF 536

  Fly   357 VAETYRVRAGIMFRQPPLSAVANIFA--MPFENDVWVSIL-MLLIITTVVLVLELFFSPHNHDM- 417
            .........|::.|:  .....::||  .||:..:|..|. .:|::.|:|.:|. :.:|....|
Zfish   537 TTRYMDYSVGVLLRK--AERTVDMFACLAPFDLSLWACIAGTVLLVGTLVYLLN-WLNPPRLPMG 598

  Fly   418 -----SYMDTLNFVWGAMCQQGFYVEVRNRSARIIVFTTFVAALFLFTSFSANIVALL--QSPSD 475
                 :..:::.||:|:..|||..|.....:.|:::...::.||.:.:|::||:.|.|  ....:
Zfish   599 SVSSTTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGVWWLFALIVISSYTANLAAFLTISRIEN 663

  Fly   476 AIQSLSDLGQ-------SPLEIGVQDTQYNKIYFTESTDPVTKNLYHKKIASKG-ENIYMRPLLG 532
            :||||.||.:       :.|:..|.|...:|.......||:...::.....:.| ||.......|
Zfish   664 SIQSLQDLAKQTDLPYGTVLDSAVYDQVRSKGMNPFERDPMYSQMWRMINRTGGAENNVEESKEG 728

  Fly   533 MEKMRTGLFAYQVELQA-GYQIVSDTFSEPEKCGLMEL------EPFQLPMLAIPTRKNFPYKEL 590
            :.|::.|.||:..:... .|..::|     |.|.|..:      ..:.:.|     :...||:::
Zfish   729 IRKVKYGRFAFVWDAAVLEYVAIND-----EDCSLYTVSNNVADRGYGMAM-----QHGSPYRDI 783

  Fly   591 IRRQLRWQREVSLVNREERKWIPQKPKCEGGVGGFVSIGITECRYALGIFGCGAAVSFVL 650
            ..:::...::...::..:.||.|:...|:    .:..:|..:...||.|... |.|.|||
Zfish   784 FSQRILELQQNGDMDILKLKWWPRDSPCD----LYSPVGTRKSGSALDIHSF-AGVFFVL 838

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75d	NP_649074.2	Periplasmic_Binding_Protein_Type_2	299..>483	CDD:304360	55/198 (28%)
Ir75d	NP_649074.2	Lig_chan	388..644	CDD:278489	59/279 (21%)
grid2	NP_001004123.1	PBP1_iGluR_delta_2	28..427	CDD:107386	38/191 (20%)
		ANF_receptor	42..404	CDD:279440	32/165 (19%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	87/382 (23%)
		Lig_chan	568..841	CDD:278489	64/287 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	989..1009
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591510
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740