DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75d and CG11155

DIOPT Version :9

Sequence 1:	NP_649074.2	Gene:	Ir75d / 40065	FlyBaseID:	FBgn0036829	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	NP_651941.2	Gene:	CG11155 / 43822	FlyBaseID:	FBgn0039927	Length:	910	Species:	Drosophila melanogaster

Alignment Length:	685	Identity:	143/685 - (20%)
Similarity:	238/685 - (34%)	Gaps:	190/685 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 DIADFRLWKLWQHFNLNNF---------YVQVSTESSLRDLQHVDALDEHKDAPPPKSFHANNST 125
            |:.|||    :...|:..|         |::|..:  ::.||| :.||.           .|.|
  Fly   263 DLEDFR----YNSVNITAFRLVDVDSKRYLEVINQ--MQKLQH-NGLDT-----------INGS- 308

  Fly   126 HWETSFLLPALPYKMGILLLEFSSECAL-NLLRWSAASEH-NYFTTNRFWLLLTEDP---GDIDL 185
                       ||......|.|.|..|. |.|.:.....| |::..|   |..|.|.   ..|.|
  Fly   309 -----------PYIQTESALMFDSVYAFANGLHFLNLDNHQNFYIKN---LSCTSDQTWNDGISL 359

  Fly   186 LEDPEIFIPPDSELRVLHYENVGN-FSCSLIDL-----YKVAAWKPLKRTLVG-------HNIRN 237
            .......|.......|...|...| |...::.|     .||..|.|.....:.       .||.|
  Fly   360 YNQINAAITDGLTGTVQFVEGRRNIFKLDILKLKQEKIQKVGYWHPDDGVNISDPTAFYDSNIAN 424

  Fly   238 SRHVI-------HALQHFGSAITYRQDLEGIVFNSAIVIAFPDLFTNIEDLSLRHIDTISKVNHR 295
            ...|:       :.:......:|.....||...:....||                   ::|..:
  Fly   425 ITLVVMTREERPYVMVKEDKNLTGNLRFEGFCIDLLKAIA-------------------TQVGFQ 470

  Fly   296 LMLELANRLNMSYNTYQTVNYGWRQPNGSFDGLMGRFQRYELDLAQLAIFMRLDRIALVDFVAET 360
            ..:||... || |..|......|   ||....||.|    ..|||..::.:...|.:::||....
  Fly   471 YKIELVPD-NM-YGVYIPETNSW---NGIVQELMER----RADLAVASMTINYARESVIDFTKPF 526

  Fly   361 YRVRAGIMFRQPPLSAVANIFAM--PFENDVWVSILMLLIITTVVLVLELFFSPH---------- 413
            ..:..||:|: .|.|....:|:.  |...::|:.:|...|:.:..|.:...|||:
  Fly   527 MNLGIGILFK-VPTSQPTRLFSFMNPLAIEIWLYVLAAYILVSFALFVMARFSPYEWKNPHPCYK 590

  Fly   414 -----NHDMSYMDTLNFVWGAMCQQGFYVEVRNRSARIIVFTTFVAALFLFTSFSANIVALLQ-- 471
                 .:..|..::..|:.|...:||..:..:..|.||:....|...|.:.:|::||:.|.|.
  Fly   591 ETDIVENQFSISNSFWFITGTFLRQGSGLNPKATSTRIVGGCWFFFCLIIISSYTANLAAFLTVE 655

  Fly   472 ---SPSDAIQSLSDLG-QSPLEIGVQDTQYNKIYFTESTDPVTKNLYHKKIASKGENIYMRPLLG 532
               ||   |:|.|||. |:.:..|..:......:|.:|           ||     .||.:....
  Fly   656 RMISP---IESASDLAEQTEISYGTLEGGSTMTFFRDS-----------KI-----GIYQKMWRY 701

  Fly   533 MEKMRTGLFAYQVE------LQAGYQIVSDT----FSEPEKC------GLMELEPFQLPMLAIPT 581
            ||..:|.:|....|      ::..|..:.::    ::....|      ||::.:.:     .|.|
  Fly   702 MENRKTAVFVKTYEDGIKRVMEGSYAFLMESTMLDYAVQRDCNLTQIGGLLDSKGY-----GIAT 761

  Fly   582 RKNFPYKELIRRQLR---------------WQREVSLVNREERKWIPQKPKCEGGVGGFVSIGIT 631
            .|..|:::.|...:.               |:....:.||:::     ..:.:....|..:||
  Fly   762 PKGSPWRDKISLAILELQEKGIIQILYDKWWKNTGDVCNRDDK-----SKESKANALGVENIG-- 819

  Fly   632 ECRYALGIFG---CGAAVSFVLFLFEFIFRHFKQV 663
                  |:|.   ||.|::.|:.:|||.:...|.:
  Fly   820 ------GVFVVLLCGLALAVVVAIFEFCWNSRKNL 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75d	NP_649074.2	Periplasmic_Binding_Protein_Type_2	299..>483	CDD:304360	52/205 (25%)
Ir75d	NP_649074.2	Lig_chan	388..644	CDD:278489	60/310 (19%)
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..410	CDD:107377	41/179 (23%)
		ANF_receptor	61..393	CDD:279440	36/162 (22%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	84/421 (20%)
		Lig_chan	555..829	CDD:278489	60/310 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462976
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840