DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir75d and Ekar

DIOPT Version :9

Sequence 1:	NP_649074.2	Gene:	Ir75d / 40065	FlyBaseID:	FBgn0036829	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster

Alignment Length:	687	Identity:	140/687 - (20%)
Similarity:	260/687 - (37%)	Gaps:	158/687 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 YRHHGVHSLMLVVCHTDIADFRLWKLWQHFNLNNFYVQVSTESSLRD-LQHVDALDEHKDAPPPK 117
            |::|.:.:...:..: |:.||:    :...|:.:|.:..:.:..::. |:.:.....|....|..
  Fly   222 YKYHYLFTSFDLETY-DLEDFK----YNFVNITSFRLVDTADVGVKQILKDIGLYSHHIFKKPYL 281

  Fly   118 SFHANNSTHWETSFLLPAL------PYKMGILLLEFSSECALNLLRWSAASEH---------NYF 167
            :.|...||..|:.   |||      .:.:|:..||.|.  :|.||..|...|:         ||.
  Fly   282 NLHIKKSTILESE---PALMFDSVYVFAIGLQTLEQSH--SLTLLNISCEEENSWDGGLSLINYL 341

  Fly   168 TTNRFWLLLTEDPGDIDLLEDPEIFIPPDSELRVLHYENVGNFSCSLIDL-----YKVAAWKP-- 225
            .... |..||   |.|...:...:                 .|...||.|     .||..|.|
  Fly   342 NAVE-WKGLT---GPIQFKDGQRV-----------------QFKLDLIKLKQHSIVKVGEWTPHG 385

  Fly   226 ---------------LKRTLVGHNIRNSRHVIHALQHFGSAITYRQDLEGIVFNSAIVIAFPDLF 275
                           :..|||...|..:.:|   :.|:|...|..:...|...:.
  Fly   386 HLNITEPSMFFDAGSMNVTLVVITILETPYV---MMHYGKNFTGNERFYGFCVDI---------- 437

  Fly   276 TNIEDLSLRHIDTISK-VNHRLMLELA-NRLNMSYNTYQTVNYGWRQP-NGSFDGLMGRFQRYEL 337
                      ::|||: |....:|:|. :|           .||.:.| .|.::|::.:..:|:.
  Fly   438 ----------LETISREVGFDYILDLVPDR-----------KYGAKDPETGEWNGMVAQLMKYKA 481

  Fly   338 DLAQLAIFMRLDRIALVDFVAETYRVRAGIMFRQPPLSAVANIFAM--PFENDVWVSILMLLIIT 400
            |||..::.:...|.:::||......:...|:|: .|.|....:|:.  |...::|:.:|:...:.
  Fly   482 DLAVGSMTITYARESVIDFTKPFMNLGISILFK-VPTSEPTRLFSFMNPLAIEIWIYVLIAYFLV 545

  Fly   401 TVVLVLELFFSP---------------HNHDMSYMDTLNFVWGAMCQQGFYVEVRNRSARIIVFT 450
            ::.:.:....||               ..:..|..|:..|..|...||...:..|..|.|||..|
  Fly   546 SLCIYIVGKLSPIEWKCINACDLENISIGNQFSLTDSFWFTIGTFMQQSPDIYPRAMSTRIISST 610

  Fly   451 TFVAALFLFTSFSANIVALLQSPS--DAIQSLSDL-GQSPLEIGVQDTQYNKIYFTESTDPVTKN 512
            ....:|.:..|::||:.|.|.:..  :.|::..|| .|:.:..|..|:.....:|.:|.....|.
  Fly   611 WGFFSLIIVASYTANLAAFLTTERMINPIENAEDLASQTEISYGTLDSGSTMTFFRDSVIETYKK 675

  Fly   513 LYHKKIASKGENIYMRPLLGMEKMRTGLFAYQVELQAGYQIVSDTFSEPEKCGLMELEPFQLPML 577
            ::......|..........|::::..|.:|:.:|......||....:..:..||::.:.:
  Fly   676 IWRSMDNKKPSAFTTTYEDGIKRVNQGNYAFLMESTMLDYIVQRDCNLTQIGGLLDTKGY----- 735

  Fly   578 AIPTRKNFPYKELIR---RQLRWQREVSLV------NREE---RKWIPQKPKCEGGVGGFVSIGI 630
            .|.|.|..|:::.|.   .:|:.:.::.::      |.:|   ||...::.|...  .|..|||
  Fly   736 GIATPKGSPWRDKISLAILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANS--LGLESIG- 797

  Fly   631 TECRYALGIFG---CGAAVSFVLFLFEFIFRHFKQVY 664
                   |:|.   .|..|:.|:..|||.: :|:..|
  Fly   798 -------GVFVVLIAGIIVAAVVAFFEFWY-NFRYNY 826

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75d	NP_649074.2	Periplasmic_Binding_Protein_Type_2	299..>483	CDD:304360	43/204 (21%)
Ir75d	NP_649074.2	Lig_chan	388..644	CDD:278489	57/288 (20%)
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	41/196 (21%)
		ANF_receptor	39..371	CDD:279440	36/179 (20%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	80/408 (20%)
		Lig_chan	533..807	CDD:278489	57/288 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462977
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840