DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir75d and KaiR1D

DIOPT Version :9

Sequence 1:	NP_649074.2	Gene:	Ir75d / 40065	FlyBaseID:	FBgn0036829	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster

Alignment Length:	675	Identity:	140/675 - (20%)
Similarity:	260/675 - (38%)	Gaps:	177/675 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 TDIADFRL------------WK-----LWQHFNLNNFYVQVSTESSLR-DLQHVDALDEHK-DAP 114
            |:|..|||            |.     |.:..||..    |.:|::|. |..|:.|...|. |..
  Fly   261 TNITGFRLINEKIVSDVVRQWSIDEKGLLRSANLTT----VRSETALMYDAVHLFAKALHDLDTS 321

  Fly   115 PPKSFH---ANNSTHWETSFLLPALPYKMGILLLEFSSECALNLLRWSAASEHNYFTTNRFWLLL 176
            .....|   .:..:.|:..|.|  :.|   :.::|...  ..|::::    :|..|.|: |.|
  Fly   322 QQIDIHPISCDGQSTWQHGFSL--INY---MKIVEMKG--LTNVIKF----DHQGFRTD-FML-- 372

  Fly   177 TEDPGDIDLLEDPEIFIPPDSELRVLHYENVGNFSCSLIDLYKVAAWKPLKRTLVGHNIRNSRHV 241
                   |::           ||.......:|.::.:|.|..........|:..:..|::|...|
  Fly   373 -------DIV-----------ELTPAGIRKIGTWNSTLPDGINFTRTFSQKQQEIEANLKNKTLV 419

  Fly   242 IHALQHFGSAITYRQDLEGIVFNSAIVIAFPDLFTNIEDLSLRHIDTISK---VNHRLMLELANR 303
            :..:  ..:....|::       |||.::..|.|   |..::..|..|||   .|:::.|
  Fly   420 VTTI--LSNPYCMRKE-------SAIPLSGNDQF---EGYAVDLIHEISKSLGFNYKIQL----- 467

  Fly   304 LNMSYNTYQTVNYGWRQPNGSFDGLMGRFQRYELDLAQLAIFMRLDRIALVDFVAETYRVRAGIM 368
              :...:|.::|    :..|.::|::........|||...:.:..:|...|||......:...|:
  Fly   468 --VPDGSYGSLN----KLTGEWNGMIRELLEQRADLAIADLTITFEREQAVDFTTPFMNLGVSIL 526

  Fly   369 FRQPPLSAVANIFAM--PFENDVWVSILMLLIITTVVLVLELFFSPHNHDMSYMDT--------- 422
            :|: |:....|:|:.  |...|||:.:....:..:|:|.:...|:|:... :|.|.
  Fly   527 YRK-PIKQPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILAKFTPYEWP-AYTDAHGEKVESQF 589

  Fly   423 --LNFVW---GAMCQQGFYVEVRNRSARIIVFTTFVAALFLFTSFSANIVALL-----QSPSDAI 477
              ||.:|   |::.|||.....:..|.|::....:...|.:.:|::||:.|.|     .||   |
  Fly   590 TLLNCMWFAIGSLMQQGCDFLPKALSTRMVAGIWWFFTLIMISSYTANLAAFLTVERMDSP---I 651

  Fly   478 QSLSDLG-QSPLEIGV----------QDTQ---YNKIY-FTESTDPVTKNLYHKKIASKGENIYM 527
            :|..||. |:.::.|.          :|::   |.::: |.||..|....      ||.||
  Fly   652 ESAEDLAKQTRIKYGALKGGSTAAFFRDSKISTYQRMWSFMESARPSVFT------ASNGE---- 706

  Fly   528 RPLLGMEKMRTGLFAYQVELQAGYQIVSDTFSEPEKC------GLMELEPFQLPMLAIPTRKNFP 586
                |:|::..|..:|...:::    .|..:.....|      |:::.:.:     .|.|..|.|
  Fly   707 ----GVERVAKGKGSYAFLMES----TSIEYVTERNCELTQVGGMLDTKSY-----GIATPPNSP 758

  Fly   587 YKELIRRQLRWQREVSLVNREERKWIPQK---PKCEGGVG---------GFVSIGITECRYALGI 639
            |:..|...:...:|...::..:.||..:|   .||.....         |..::|        |:
  Fly   759 YRTAINSVILKLQEEGKLHILKTKWWKEKRGGGKCRVETSKSSSAANELGLANVG--------GV 815

  Fly   640 FGC---GAAVSFVLFLFEFIFRHFK 661
            |..   |..|:.|:.:.||:::..|
  Fly   816 FVVLMGGMGVACVIAVCEFVWKSRK 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75d	NP_649074.2	Periplasmic_Binding_Protein_Type_2	299..>483	CDD:304360	45/204 (22%)
Ir75d	NP_649074.2	Lig_chan	388..644	CDD:278489	65/310 (21%)
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	35/171 (20%)
		ANF_receptor	42..378	CDD:279440	31/152 (20%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	90/420 (21%)
		Lig_chan	547..823	CDD:278489	65/310 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910