DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir75d and gria4a

DIOPT Version :9

Sequence 1:	NP_649074.2	Gene:	Ir75d / 40065	FlyBaseID:	FBgn0036829	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	NP_999971.1	Gene:	gria4a / 407735	ZFINID:	ZDB-GENE-020125-7	Length:	898	Species:	Danio rerio

Alignment Length:	713	Identity:	145/713 - (20%)
Similarity:	264/713 - (37%)	Gaps:	189/713 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 FYVQVSTESSLRDLQHVDALDEHKDAPPPKSFHANNSTHWETSFLLPALPYK------------- 139
            |.:.:..|.....|:.:.::.:|     .|.:|          :::..|.:|
Zfish   204 FVIDLEAERLQNILEQIVSVGKH-----VKGYH----------YIVANLGFKDISLERFMHGGAN 253

  Fly   140 -MGILLLEFSSECALNLL-RWSAASEHNY---FTTNRFWLLLTEDPGDIDLLEDPEIFIPPDSEL 199
             .|..|::||....:.|: ||:...:..|   .:..|:...||.|    .:|...|.|
Zfish   254 VTGFQLVDFSKPMVIKLMQRWNKLDQREYPGSESPPRYTSSLTYD----GVLVMAEAF------- 307

  Fly   200 RVLHYENV-----GNFSCSLIDLYKVAAWK---PLKRTLVGHNIRNSRHVIHALQHFGSAITYRQ 256
            |.|..:.:     ||....|.:  ..|.|.   .::|||....|:.....|. ..|:|..:.|..
Zfish   308 RNLRRQKIDISRRGNAGDCLAN--PAAPWNQGIDMERTLKQVRIQGLTGNIQ-FDHYGRRVNYTM 369

  Fly   257 DLEGIVFNSAIVIAF-PDLFTNI---EDLSLRH----------IDTIS-------KVNHR----- 295
            |:..:..|....|.: .||...:   .:||:.:          :.||.       |.|..
Zfish   370 DVFELKSNGPRKIGYWNDLDKLVLVQNELSMGNDSAMENRTVIVTTIMEGPYVMLKKNWEMYEGN 434

  Fly   296 ---------LMLELANRLNMSYNTYQTVN--YGWRQPNGS-FDGLMGR--FQRYELDLAQLAIFM 346
                     |..|:|..:.:.|.....::  ||.|.|... ::|::|.  :.:.|:.:|.|||
Zfish   435 EQFEGYCVDLASEVAKHIGIKYKISIVLDGKYGARDPETKIWNGMVGELVYGKAEIAVAPLAI-- 497

  Fly   347 RLDRIALVDFVAETYRVRAGIMFRQPPLSAVANIFAM--PFENDVWVSILMLLIITTVVLVLELF 409
            .|.|..::||......:...||.::|..|. ..:|:.  |...::|:.|:...|..:|||.|...
Zfish   498 TLVREEVIDFSKPFMSLGISIMIKKPQKSK-PGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSR 561

  Fly   410 FSPHN-------------------HDMSYMDTLNFVWGAMCQQGFYVEVRNRSARIIVFTTFVAA 455
            |||:.                   ::....::|.|..||..|||.....|:.|.||:....:...
Zfish   562 FSPYEWHTEEPEEGSDGPPSDQPPNEFGIFNSLWFSLGAFMQQGCDFTPRSLSGRIVGGVWWFFT 626

  Fly   456 LFLFTSFSANIVALLQ-----SPSDAIQSLSDLG-QSPLEIGVQDTQYNKIYFTESTDPVTKNLY 514
            |.:.:|::||:.|.|.     ||   |:|..||. |:.:..|..|:...|.:|..|...|.:.::
Zfish   627 LIIISSYTANLAAFLTVERMVSP---IESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMW 688

  Fly   515 HKKIASKGENIYMRPLL-GMEKMR--TGLFAYQVELQAGYQIVSDTFSEPEK-CGLMEL------ 569
             ..:.|....::.:... |:.::|  .|.:|:.:|      ...:.::|..| |..|::
Zfish   689 -SYMKSAEPTVFTKTTAEGVARVRKSKGKYAFLLE------STMNEYTEQRKPCDTMKVGGNLDS 746

  Fly   570 --------------EPFQLPMLAIPTRKNFPYKELIRRQLRWQREVSLVNREERKWIPQKPKC-- 618
                          .|..|.:|.:                   .|..::::.:.||...|.:|
Zfish   747 KGYGVATPKGSQLGTPVNLAVLKL-------------------SEAGVLDKLKNKWWYDKGECGP 792

  Fly   619 -EGGVGGFVSIGITECRYALGIF-----GCGAAVSFVLFLFEFIFRHFKQVYRIIKGYREVQR 675
             :.|.....|..::....| |:|     |.|.|:  ::.|.||.::...:..::...:.|..|
Zfish   793 KDSGSKDKSSQALSLSNVA-GVFYILVGGLGLAM--LVALVEFCYKSRAEAKKLKLTFSEAMR 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75d	NP_649074.2	Periplasmic_Binding_Protein_Type_2	299..>483	CDD:304360	55/214 (26%)
Ir75d	NP_649074.2	Lig_chan	388..644	CDD:278489	64/312 (21%)
gria4a	NP_999971.1	PBP1_iGluR_AMPA_GluR4	23..393	CDD:107383	43/217 (20%)
		ANF_receptor	34..375	CDD:279440	39/199 (20%)
		PBP2_iGluR_AMPA_GluR4	408..790	CDD:270445	86/413 (21%)
		Lig_chan	540..821	CDD:278489	63/310 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591540
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.940