DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75d and gria1b

DIOPT Version :9

Sequence 1:	NP_649074.2	Gene:	Ir75d / 40065	FlyBaseID:	FBgn0036829	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	NP_991293.1	Gene:	gria1b / 403044	ZFINID:	ZDB-GENE-020125-2	Length:	917	Species:	Danio rerio

Alignment Length:	767	Identity:	153/767 - (19%)
Similarity:	269/767 - (35%)	Gaps:	216/767 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 LWQHFNLNNFYVQVSTESSLRDLQHVDALDEHKDAPPPKSFHA---NNSTHWETSFL--LPALPY 138
            |.:|:..|.|....|::|.|..||.:      .|....|::..   |..|..|.:||  :..|..
Zfish   135 LVEHYKWNKFVYMYSSDSGLTVLQKI------LDTAAEKTWQVTSINFDTLTEAAFLKAIQDLDN 193

  Fly   139 KMGI-LLLEFSSECALNLLRWSAASEHN-----YFTTNRFWLLLTEDPGDIDLLE---------- 187
            |... ::|:...|...::|...||.:.|     |...|..:|       |::|.|
Zfish   194 KKEFKIILDCELERLNSILNLIAAQKKNLKNYHYILANLGFL-------DLNLTEFRKGGANVTG 251

  Fly   188 ---------------------DPEIFIPPDSELR---VLHYENVGNFSCSLIDLYK--------- 219
                                 |.:....|...|:   .|.|:.|...:.:..:|.|
Zfish   252 FQLMNYTNPTVSRTIQDWLEFDSKDLKSPKRRLKYTGALTYDGVTVMATAFQNLRKQRIDISRRG 316

  Fly   220 ---------VAAW-------KPLKRT----LVGH---NIRNSR-HVIHALQHFGSA----ITYRQ 256
                     .|.|       :.|::.    |.||   |.:..| :...::..||.:    :.|..
Zfish   317 NAGECLANPPAPWGQGIDIQRALQQVQFEGLTGHVQFNDKGHRTNFTVSVMEFGPSGPKKVGYWN 381

  Fly   257 DLEGIVFNSAIVIAFPDLFTNI--EDLSLRH----IDTI-------SKVNH-------------- 294
            ..|..|..:.        ::|:  |...|::    :.||       .|.||
Zfish   382 QREKYVSTAT--------YSNMLNETFGLQNRTYVVTTILEAPYVMLKKNHEQLVGNDKYEGYCV 438

  Fly   295 RLMLELANRLNMSYNTYQTV---NYGWRQPNG-SFDGLMGRFQRYELDLAQLAIFMRLDRIALVD 355
            .|..|:|..:..||. .:.|   .||.|.... .::|::|.....:.|:|...:.:.|.|..::|
Zfish   439 ELAAEIAKHVGYSYR-LELVGDGKYGARDAETMMWNGMVGELVYGKADVAVAPLTITLVREEVID 502

  Fly   356 FVAETYRVRAGIMFRQPPLSAVANIFAM--PFENDVWVSILMLLIITTVVLVLELFFSP------ 412
            |......:...||.::|..|. ..:|:.  |...::|:.|:...|..:|||.|...|||
Zfish   503 FSKPFMSLGISIMIKKPTKSK-PGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHAD 566

  Fly   413 ---------------------------------------HNHDMSYMDTLNFVWGAMCQQGFYVE 438
                                                   |.::....::|.|..||..|||..:.
Zfish   567 DEEETADQQNQNQPPSPEPNQSPNQSQNQREEKQEKQPEHTNEFGIFNSLWFSLGAFMQQGCDIS 631

  Fly   439 VRNRSARIIVFTTFVAALFLFTSFSANIVALLQ-----SPSDAIQSLSDLG-QSPLEIGVQDTQY 497
            .|:.|.||:....:...|.:.:|::||:.|.|.     ||   |:|..||. |:.:..|..|...
Zfish   632 PRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSP---IESAEDLAKQTEIAYGTLDGGS 693

  Fly   498 NKIYFTESTDPVTKNLYHKKIASKGENIYMRPL-LGMEKMR--TGLFAYQVELQAGYQIVSDTFS 559
            .|.:|..|...|.:.:: ..:.|....::::.. .|:.::|  .|.:||.:|     ..:::...
Zfish   694 TKEFFRRSKIAVFEKMW-SYMKSAEPTVFVKTTDEGVVRVRKSKGKYAYLLE-----STMNEYIE 752

  Fly   560 EPEKCGLMEL-EPFQLPMLAIPTRKNFPYKELIRRQLRWQREVSLVNREERKWIPQKPKCEGGVG 623
            :.:.|..|:: .........:.|.|....:..:...:....|..|:::.:.||...|.:|  |.|
Zfish   753 QRKPCDTMKVGGNLDSKGYGVATPKGSALRNPVNLAVLKLNEQGLLDKLKNKWWYDKGEC--GSG 815

  Fly   624 GFVSIGITECRYALGIFGC------GAAVSFVLFLFEFIF------RHFKQV 663
            |..|...|.......:.|.      |..::.::.|.||.:      |..||:
Zfish   816 GGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALVEFCYKSRIESRRMKQI 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75d	NP_649074.2	Periplasmic_Binding_Protein_Type_2	299..>483	CDD:304360	54/239 (23%)
Ir75d	NP_649074.2	Lig_chan	388..644	CDD:278489	64/316 (20%)
gria1b	NP_991293.1	PBP1_iGluR_AMPA_GluR1	26..387	CDD:107385	50/264 (19%)
		ANF_receptor	41..368	CDD:279440	46/245 (19%)
		PBP2_iGluR_AMPA_GluR1	404..812	CDD:270447	85/418 (20%)
		Lig_chan	536..842	CDD:278489	64/316 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591475
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.840