DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir75d and GluRIIE

DIOPT Version :9

Sequence 1:	NP_649074.2	Gene:	Ir75d / 40065	FlyBaseID:	FBgn0036829	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster

Alignment Length:	447	Identity:	91/447 - (20%)
Similarity:	171/447 - (38%)	Gaps:	103/447 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   296 LMLELANRLNMSY------NTYQTVNYGWRQPNGSFDGLM-GRFQRYELDLAQLAIFMRLDRIAL 353
            |:.|||::|..::      |.|.:.|....:..|....:| ||     .|||...:.:..:|...
  Fly   456 LIKELADKLGFNFTFVNGGNDYGSYNKSTNESTGMLREIMTGR-----ADLAITDLTITSEREQA 515

  Fly   354 VDFVAETYRVRAGIMFRQPPLSAVANIFAM--PFENDVWVSILMLLIITTVVLVLELF----FSP 412
            :||......:...|::.:|. .|...:|..  ||..:||    ..|..:.:.:.|..|    .||
  Fly   516 LDFTIPFMNLGIAILYLKPQ-KATPELFTFMDPFSEEVW----WFLGFSFLGVSLSFFILGRLSP 575

  Fly   413 HNHDMSY-----------MDTL-NFVW---GAMCQQGFYVEVRNRSARIIVFTTFVAALFLFTSF 462
            ...|..|           ..|| |.:|   ||:.|||..:..:..|.|.:....:...|.:.:|:
  Fly   576 SEWDNPYPCIEEPEELENQFTLGNSIWFTTGALLQQGSEIGPKALSTRTVASFWWFFTLIVVSSY 640

  Fly   463 SANIVALL--QSPSDAIQSLSDLGQSP--LEIGVQDTQYNKIYFTESTDPVTKNLYHKKIASKGE 523
            :||:.|.|  :.|...|.|:.||..:.  :..|.:.|...:.:|..|.:...|.: :|.::...:
  Fly   641 TANLAAFLTIEKPQSLINSVDDLADNKDGVVYGAKKTGSTRNFFMTSAEERYKKM-NKFMSENPQ 704

  Fly   524 NIYMRPLLGMEKMRTGL-FAYQVELQAGYQIVSDTFSEPEKCGLMEL-EPFQLPMLAIPTRKNFP 586
            .:....:.|:.:::|.. :|:.:|      ..|..::...:|.|.:: :........|..||::|
  Fly   705 YLTEDNMEGVNRVKTNTHYAFLME------STSIEYNTKRECNLKKIGDALDEKGYGIAMRKDWP 763

  Fly   587 YKELIRRQLRWQREVSLVNREERKWIPQKPKCEGGVGGFVSIGITECR----------------- 634
            ::......|...:|..::.:.:.||..:           |..||...:
  Fly   764 HRGKFNNALLELQEQGVLEKMKNKWWNE-----------VGTGICATKEDAPDATPLDMNNLEGV 817

  Fly   635 -YALGIFGCGA----AVSFVLFL------------------FEFIFRHFKQVYRIIK 668
             :.|.:..|.|    .:|:|||:                  |:|:. .|....|::|
  Fly   818 FFVLLVGSCCALLYGIISWVLFVMKKAHHYRVPLRDALKEEFQFVI-DFNNYVRVLK 873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75d	NP_649074.2	Periplasmic_Binding_Protein_Type_2	299..>483	CDD:304360	52/213 (24%)
Ir75d	NP_649074.2	Lig_chan	388..644	CDD:278489	57/298 (19%)
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377
		ANF_receptor	51..382	CDD:279440
		PBP2_iGluR_Kainate	419..790	CDD:270432	76/350 (22%)
		Lig_chan	551..824	CDD:278489	56/294 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462826
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840