DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir75d and Gria4

DIOPT Version :9

Sequence 1:	NP_649074.2	Gene:	Ir75d / 40065	FlyBaseID:	FBgn0036829	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	NP_001106655.1	Gene:	Gria4 / 29629	RGDID:	61863	Length:	902	Species:	Rattus norvegicus

Alignment Length:	725	Identity:	144/725 - (19%)
Similarity:	268/725 - (36%)	Gaps:	151/725 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 HGVHSLMLVVCHTDIADFRLWKLWQHFNL---NNFYVQVSTESSLRDLQHVDALDEHKDAPPPKS 118
            :|.|  :..:|..:..|....:|.:..:.   ..|.:....|.....|:.:.::.:|     .|.
  Rat   177 NGWH--VSAICVENFNDVSYRQLLEELDRRQEKKFVIDCEIERLQNILEQIVSVGKH-----VKG 234

  Fly   119 FHANNSTHWETSFLLPALPYK--------------MGILLLEFSSECALNLL-RWSAASEHNY-- 166
            :|          :::..|.:|              .|..|::|::.....|: ||....:..|
  Rat   235 YH----------YIIANLGFKDISLERFIHGGANVTGFQLVDFNTPMVTKLMDRWKKLDQREYPG 289

  Fly   167 -FTTNRFWLLLTEDPGDIDLLEDPEIFIPPDSELRVLHYENV-----GNFSCSLIDLYKVAAWK- 224
             .|..::...||.|    .:|...|.|       |.|..:.:     ||....|.:  ..|.|.
  Rat   290 SETPPKYTSALTYD----GVLVMAETF-------RSLRRQKIDISRRGNAGDCLAN--PAAPWGQ 341

  Fly   225 --PLKRTLVGHNIRNSRHVIHALQHFGSAITYRQDLEGIVFNSAIVIAF---PDLFTNIEDLSLR 284
              .::|||....|:.....:. ..|:|..:.|..|:..:.......:.:   .|....|:|:...
  Rat   342 GIDMERTLKQVRIQGLTGNVQ-FDHYGRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQDMPTL 405

  Fly   285 HIDTIS-------------------KVNHR--------------LMLELANRLNMSYN--TYQTV 314
            ..||.:                   |.||.              |..|:|..:.:.|.  .....
  Rat   406 GNDTAAIENRTVVVTTIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIAIVPDG 470

  Fly   315 NYGWRQPNGS-FDGLMGR--FQRYELDLAQLAIFMRLDRIALVDFVAETYRVRAGIMFRQPPLSA 376
            .||.|..:.. ::|::|.  :.:.|:.:|.|.|  .|.|..::||......:...||.::|..|.
  Rat   471 KYGARDADTKIWNGMVGELVYGKAEIAIAPLTI--TLVREEVIDFSKPFMSLGISIMIKKPQKSK 533

  Fly   377 VANIFAM--PFENDVWVSILMLLIITTVVLVLELFFSPHN------------------HDMSYMD 421
             ..:|:.  |...::|:.|:...|..:|||.|...|||:.                  ::....:
  Rat   534 -PGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKEGPSDQPPNEFGIFN 597

  Fly   422 TLNFVWGAMCQQGFYVEVRNRSARIIVFTTFVAALFLFTSFSANIVALLQ-----SPSDAIQSLS 481
            :|.|..||..|||..:..|:.|.||:....:...|.:.:|::||:.|.|.     ||   |:|..
  Rat   598 SLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSP---IESAE 659

  Fly   482 DLG-QSPLEIGVQDTQYNKIYFTESTDPVTKNLYHKKIASKGENIYMRPLL-GMEKMR--TGLFA 542
            ||. |:.:..|..|:...|.:|..|...|.:.:: ..:.|...:::.|... |:.::|  .|.||
  Rat   660 DLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMW-TYMRSAEPSVFTRTTAEGVARVRKSKGKFA 723

  Fly   543 YQVELQAGYQIVSDTFSEPEKCGLMEL-EPFQLPMLAIPTRKNFPYKELIRRQLRWQREVSLVNR 606
            :.:|     ..:::...:.:.|..|:: .........:.|.|....:..:...:....|..|:::
  Rat   724 FLLE-----STMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRNAVNLAVLKLNEQGLLDK 783

  Fly   607 EERKWIPQKPKCEGGVGGFVSIGITECRYALGIFGC------GAAVSFVLFLFEFIFRHFKQVYR 665
            .:.||...|.:|  |.||..|...|.......:.|.      |..::.::.|.||.::...:..|
  Rat   784 LKNKWWYDKGEC--GSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKR 846

  Fly   666 IIKGYREVQR 675
            :...:.|..|
  Rat   847 MKLTFSEAIR 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir75d	NP_649074.2	Periplasmic_Binding_Protein_Type_2	299..>483	CDD:304360	53/213 (25%)
Ir75d	NP_649074.2	Lig_chan	388..644	CDD:278489	64/289 (22%)
Gria4	NP_001106655.1	PBP1_iGluR_AMPA_GluR4	28..398	CDD:107383	43/251 (17%)
		ANF_receptor	39..380	CDD:279440	42/233 (18%)
		PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	83/392 (21%)
		Lig_chan	546..825	CDD:278489	64/289 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350047
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840