back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir75d and GRIN2D

DIOPT Version :9

Sequence 1:	NP_649074.2	Gene:	Ir75d / 40065	FlyBaseID:	FBgn0036829	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	NP_000827.2	Gene:	GRIN2D / 2906	HGNCID:	4588	Length:	1336	Species:	Homo sapiens

Alignment Length:	585	Identity:	121/585 - (20%)
Similarity:	204/585 - (34%)	Gaps:	143/585 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 APPPKSFHANNSTHWETSFL-------------LPALPYKMGILLLEFSSECALNLLRWSAASEH 164
            ||.|....|..|..|.....             ..||....| .|.|...:|..........|.|
Human   298 APLPAGLFAVRSAGWRDDLARRVAAGVAVVARGAQALLRDYG-FLPELGHDCRAQNRTHRGESLH 361

  Fly   165 NYFTTNRFWLLLTEDPGDIDLLED-----PEIFIPPDSELRVLHYENVGNFSCSLIDLYKVAAWK 224
            .||      :.:|.|..|....||     |.:.:  .|..|...:|.||::....:.| |...|.
Human   362 RYF------MNITWDNRDYSFNEDGFLVNPSLVV--ISLTRDRTWEVVGSWEQQTLRL-KYPLWS 417

  Fly   225 PLKRTLVGHNIRNSRHVIHALQHFGSAITYRQDLEGIVFNSAIVI--AFPDLFTNIEDLSLRHID 287
            ...|.|  ..:.:::|:..|            .||...|   :::  |.|...|.|.|    .:.
Human   418 RYGRFL--QPVDDTQHLTVA------------TLEERPF---VIVEPADPISGTCIRD----SVP 461

  Fly   288 TISKVNHR---------------------LMLELANRLNMSYNTYQTVN--YGWRQPNGSFDGLM 329
            ..|::|..                     ::..||:.:..||:.|...|  :| ::.:|.::|::
Human   462 CRSQLNRTHSPPPDAPRPEKRCCKGFCIDILKRLAHTIGFSYDLYLVTNGKHG-KKIDGVWNGMI 525

  Fly   330 GR--FQRYELDLAQLAIFMRLDRIALVDFVAETYRVRAGIMFRQPPLSAVANIFAMPFENDVWVS 392
            |.  :||.::.:..|.|  ..:|..:|||..........:|..:...:...:.|..|:...|||.
Human   526 GEVFYQRADMAIGSLTI--NEERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVWVM 588

  Fly   393 --ILMLLIITTVVLVLELFFSPHNHDMSYM-------------DTLNFVWGAMCQQGFYVE-VRN 441
              ::.|.::...|.:.| :.||..::.|..             .::..:|..:......|| .|.
Human   589 MFVMCLTVVAVTVFIFE-YLSPVGYNRSLATGKRPGGSTFTIGKSIWLLWALVFNNSVPVENPRG 652

  Fly   442 RSARIIVFT-TFVAALFLFTSFSANIVALL--QSPSDAIQSLSDLG-QSPLEIGVQDTQYNKIYF 502
            .:::|:|.. .|.|.:|| .|::||:.|.:  :...|.:..|||.. |.|.|      ||..:.|
Human   653 TTSKIMVLVWAFFAVIFL-ASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQE------QYPPLKF 710

  Fly   503 -TESTDPVTKNL------YHKKIASKGENIYMRPLLGMEKMRTGLFAYQVELQAGYQIVSDTFSE 560
             |.......||:      .|..:....:......|..::..:...|.|...: ..|....|
Human   711 GTVPNGSTEKNIRSNYPDMHSYMVRYNQPRVEEALTQLKAGKLDAFIYDAAV-LNYMARKD---- 770

  Fly   561 PEKCGLMELEPFQLPMLAIPTRKNFP---YKELIRRQLRWQREVSL----------VNREERKWI 612
             |.|.|          :.|.:.|.|.   |...:.:..||:|.:.|          :...||.|:
Human   771 -EGCKL----------VTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWL 824

Fly 613 612
Human 825 824

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.